한국산업보건학회지 (Journal of Korean Society of Occupational and Environmental Hygiene)

  • 제33권3호
  • /
  • Pages.355-364
  • /
  • 2023
  • /
  • 2384-132X(pISSN)
  • /
  • 2289-0564(eISSN)
한국산업보건학회 (Korean Industrial Hygiene Association)
권호 표지
DOI QR코드

DOI QR Code

요양 비대상인 분진작업 이직근로자에서 마이코박테리아 감염

Mycobacterial Infection among Retired Dusty Workers Ineligible for Medical Care Benefits for Work-related Pneumoconiosis

  • 황주환 (근로복지공단 직업환경연구원 발병기전연구부)
  • Joo Hwan Hwang (Department of Pathogenic Laboratory Research, Institute of Occupation and Environment, the Korea Workers' Compensation and Welfare Service)
  • 투고 : 2023.07.18
  • 심사 : 2023.08.25
  • 발행 : 2023.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The objective of the present study was to identify mycobacterial infection in retired dusty workers who were ineligible for medical care benefits for work-related pneumoconiosis. Methods: Sputum samples were collected from 170 retired dusty workers living in Gangwon-do. The mycobacterial culture was grown in 2% Ogawa medium and Mycobacteria Growth Indicator Tube(MGIT). Mycobacterial species were identified using MolecuTech REBA Myco-IDⓇ. Results: Thirty-one(18.2%) out of 170 sputum samples were identified as positive for culture. Among the positive culture samples, eleven(6.5%) were identified as mycobacterial species. The proportion of mycobacteria was M. avium 2.3%(4/170), M. fortuitum complex 1.2%(2/170), M. intracellulare 1.2%(2/170), M. abscessus 0.6%(1/170), M. tuberculosis(MTB) complex 0.6%(1/170), and MYC(NTM except 19 species) 0.6%(1/170). Conclusions: In comparison with previous studies, the incidence rate of tuberculosis(TB) in retired dusty workers who were ineligible for medical care benefits for work-related pneumoconiosis was higher than in close contact with TB patients, workers exposed to silica, and patients with silicosis. And the proportion of non-tuberculosis mycobacteria(NTM) was higher than that of MTB.

키워드

참고문헌

  1. Altet N, Dominguez J, Souza-Galvao ML, JimenezFuentes MA, Mila C et al. Predicting the development of tuberculosis with the tuberculin skin test and QuantiFERON testing. Ann Am Thorac Soc. 2015 May;12(5): 680-8. https://doi: 10.1513/AnnalsATS.201408-394OC
  2. Al Zahrani K, Al Jahdali H, Poirier L, Rene P, Menzies D. Yield of smear, culture and amplification tests from repeated sputum induction for the diagnosis of pulmonary tuberculosis. Int J Tuberc Lung Dis. 2001 Sep;5(9): 855-60
  3. American Thoracic Society (ATS). Diagnostic standard and classification of tuberculosis in adults and children. Am J Respir Crit Care Med. 2000 161:1376-1395 https://doi.org/10.1164/ajrccm.161.4.16141
  4. Cho H, Kim JB, Uh Y. Frequency of Mycobacterium tuberculosis among M. tuberculosis complex strains isolated from clinical specimen. Ann Clin Microbiol 2020;23(1):21-12. https://doi:https://doi.org/10.5145/ACM.2020.23.1.1
  5. Geis S, Bettge-Weller G, Goetsch U, Bellinger O, Ballmann G et al. How can we achieve better prevention of progression to tuberculosis among contacts?. Eur Respir J. 2013 Dec;42(6):1743-6. https://doi:10.1183/09031936.00187112. Epub 2013 Jul 30
  6. Goebel KM, Tay EL, Denholm JT. Supplemental use of an interferon-gamma release assay in a state-wide tuberculosis contact tracing program in Victoria: a six-year review. Commun Dis Intell Q Rep. 2015 Jun 30; 39(2):E191-6
  7. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416. https://doi:10.1164/rccm.200604-571ST
  8. Hwang JH, Shin JH, Baek JE, Choi BS. Risk factors for associated with latent tuberculosis infection among former mine workers. J Korean Soc Occup Environ Hyg, 2019;29(3):289-297. https://doi:10.15269/JKSOEH.2019.29.3.289
  9. Hwang JH. Attack rate of active pulmonary tuberculosis among dusty workers who were diagnosed with pneumoconiosis in Korea. J Korean Soc Occup Environ Hyg, 2019; 29(4):582-589. https://doi.org/10.15269/JKSOEH.2019.29.4.582
  10. Hwang JH. Development of active tuberculosis among former dusty workers who diagnosed with latent tuberculosis infection. J Korean Soc Occup Environ Hyg. 2020;30(1):67-74. https://doi.org/10.15269/JKSOEH.2020.30.1.67
  11. Joint Committee for the Revision of Korean Guidelines for Tuberculosis and Korea Centers for Disease Control and Prevention (JCRKGT and KCDC). Korean Guidelines for Tuberculosis third Edition. 2017. The Korean Academy of Tuberculosis and Respiratory Disease [cited 2017 May 17]. Available from: URL:https://www.lungkorea.org/bbs/index.html?code=guide&category=&gubun=&page=1&number=7563&mode=view&keyfield=&key=
  12. Kim YM, Kim M, Kim SK, Park K, Jin SH et al. Mycobacterial infections in coal workers' pneumoconiosis patients in South Korea. Scand J Infect Dis. 2009;41(9):656-62 https://doi.org/10.1080/00365540903089468
  13. Koh WJ, Kwon OJ. Diagnosis and treatment of pulmonary tuberculosis. Tuberc Respir Dis. 2005;58(5): 438-451 https://doi.org/10.4046/trd.2005.58.5.438
  14. Lee YM. Study on legal issues of the pneumoconiosis compensation [Internet]. Graduate School of Labor Studies Korea University 2016 [cited Feb 2016]. Available from: URL:https://www.riss.kr/search/detail/DetailView.do?p_mat_type=be54d9b8bc7cdb09&control_no=e7deb12e2a6b957affe0bdc3ef48d419&outLink=K
  15. Leung CC, Yam WC, Yew WW, Ho PL, Tam CM et al. T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease. Am J Respir Crit Care Med. 2010 Sep 15;182(6):834-40. https://doi:10.1164/rccm.200912-1875OC. Epub 2010 May 27
  16. Park K. Studies on the actual state of the in-home pneumoconiosis and social welfare approach - focusing on Tae-Back area. 2015. Graduate School of Public Administration Sangji University [cited 2015]. Available from: URL:https://www.riss.kr/link?id=T10892352
  17. Park Y, Kim SY, Kim JW, Park MS, Kim YS et al. Serial testing of healthcare workers for latent tuberculosis infection and long-term follow up for development of active tuberculosis. PLoS One. 2018 Sep 20;13(9):e0204035. https://doi:10.1371/journal.pone.0204035. eCollection 2018
  18. Ringshausen FC, Nienhaus A, Schablon A, Torres Costa J, Knoop H et al. Frequent detection of latent tuberculosis infection among aged underground hard coal miners in the absence of recent tuberculosis exposure. PLoS One. 2013 Dec 2;8(12):e82005. https://doi:10.1371/journal.pone.0082005
  19. Yun HS. A study on the change of living conditions for the pneumoconiosis in home (Focused on the Before and After Pneumoconiosis Compensation Benefits). 2012. Graduate School of Science and Technology Kyungpook National University [cited 2012]. Available from: URL:http://www.riss.kr/search/detail/DetailView.do?p_mat_type=be54d9b8bc7cdb09&control_no=7767c7c93cdcaa00ffe0bdc3ef48d419&outLink=K
  20. Zellweger JP, Sotgiu G, Block M, Dore S, Altet N et al. Risk assessment of tuberculosis in contacts by IFN-γ release assays. A Tuberculosis Network European Trials Group Study. Am J Respir Crit Care Med. 2015 May 15;191(10):1176-84. https://doi:10.1164/rccm.201502-0232OC