Korean Journal of Acupuncture

  • 제40권3호
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  • Pages.109-127
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  • 2023
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  • 2287-3368(pISSN)
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  • 2287-3376(eISSN)
경락경혈학회 (Society for Meridian and Acupoint)
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고지방식이 및 일반식이 백서에 대한 중완·천추·족삼리 침자의 유효성 검증

The Effect of CV12, ST25, ST36 Acupuncture in General Diet and High Fat Diet Rat

  • 김경수 (동신대학교 한의과대학 한의학과) ;
  • 김명훈 (동신대학교 한의과대학 한의학과) ;
  • 설재욱 (동신대학교 한의과대학 한의학과) ;
  • 김은주 (고려대학교 식품공학과) ;
  • 손홍석 (고려대학교 식품공학과) ;
  • 나창수 (동신대학교 한의과대학 한의학과)
  • Kyeong-Soo Kim (Department of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Myeong-Hun Kim (Department of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Jae-Uk Sul (Department of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Eun-Ju Kim (Department of Biotechnology, Korea University) ;
  • Hong-Seok Son (Department of Biotechnology, Korea University) ;
  • Chang-Su Na (Department of Korean Medicine, College of Korean Medicine, Dongshin University)
  • 투고 : 2023.08.28
  • 심사 : 2023.09.19
  • 발행 : 2023.09.27
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초록

Objectives : It was conducted to experimentally analyze the effects of acupuncture treatment at CV12, ST25, and ST36 on weight, FBCS, fat metabolism, microbiome, and metabolome changes in the general diet rat and the high-fat diet rat. Methods : It was classified into four groups: general diet & non-treatment group (ND), general diet & acupuncture treatment group (ND+AT), high-fat diet & non-treatment group (HFD), and high-fat diet & acupuncture treatment group (HFD-AT). After acupuncture treatment was performed on CV12, ST25, and ST36, changes in body weight, FBCS, fat metabolism, microbiome, and metabolome were analyzed. Results : Compared to the ND group, acupuncture treatment performed on CV12, ST25, and ST36 in the ND+AT group had no significant effect. Compared to the HFD group, CV12, ST25, and ST36 acupuncture in the HFD+AT group reduced weight, fat weight, inflammatory cytokine IL-6 expression, and lipid droplet accumulation in liver tissue. Acupuncture can promote fat metabolism and relieve inflammatory conditions. Differences in diversity between ND and HFD groups were clear in changes in microbiome, fecal metabolites, and serum metabolites. As a result of some microbiome and metabolites involved in fat decomposition, intestinal lipid absorption, and blood lipid concentration control, such as Intestinimonas, Ruminococcus 1, pyroglutamic acid, tryptophan, and inositol, it was observed that the acupuncture treatment effect was evident in the disease-induced imbalance. Conclusions : Acupuncture treatment performed on CV12, ST25, ST36 clearly observed various regulatory actions on obesity induced by high-fat diet, confirming that the action of acupuncture treatment mainly plays a role in controlling an unbalanced state.

키워드

과제정보

This research was supported by the Dongshin University research grants. This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT) (NRF-2020R1A2C2009926).

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