Journal of Ginseng Research

  • 제47권5호
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  • Pages.672-680
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  • 2023
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Korean Red Ginseng extract ameliorates demyelination by inhibiting infiltration and activation of immune cells in cuprizone-administrated mice

  • Min Jung Lee (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Jong Hee Choi (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Tae Woo Kwon (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Hyo-Sung Jo (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Yujeong Ha (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Seung-Yeol Nah (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Ik-Hyun Cho (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University)
  • 투고 : 2022.08.08
  • 심사 : 2023.05.09
  • 발행 : 2023.09.01
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초록

Background: Korean Red Ginseng (KRG), the steamed root of Panax ginseng, has pharmacological activities for immunological and neurodegenerative disorders. But, the role of KRGE in multiple sclerosis (MS) remains unclear. Purpose: To determine whether KRG extract (KRGE) could inhibit demyelination in corpus callosum (CC) of cuprizone (CPZ)-induced murine model of MS Methods: Male adult mice were fed with a standard chow diet or a chow diet supplemented with 0.2% (w/w) CPZ ad libitum for six weeks to induce demyelination while were simultaneously administered with distilled water (DW) alone or KRGE-DW (0.004%, 0.02 and 0.1% of KRGE) by drinking. Results: Administration with KRGE-DW alleviated demyelination and oligodendrocyte degeneration associated with inhibition of infiltration and activation of resident microglia and monocyte-derived macrophages as well as downregulation of proinflammatory mediators in the CC of CPZ-fed mice. KRGE-DW also attenuated the level of infiltration of Th1 and Th17) cells, in line with inhibited Mrna expression of IFN-γ and IL-17, respectively, in the CC. These positive effects of KRGE-DW mitigated behavioral dysfunction based on elevated plus maze and the rotarod tests. Conclusion: The results strongly suggest that KRGE-DW may inhibit CPZ-induced demyelination due to its oligodendroglial protective and anti-inflammatory activities by inhibiting infiltration/activation of immune cells. Thus, KRGE might have potential in therapeutic intervention for MS.

키워드

과제정보

This research was supported by grant from the Korean Society of Ginseng (2018, 2022).

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