Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of anti-skin disorders of ginsenosides- A Systematic Review

  • Lele Cong (Department of Dermatology, China-Japan Union Hospital of Jilin University) ;
  • Jinli Ma (Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery, China-Japan Union Hospital of Jilin University) ;
  • Yundong Zhang (Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery, China-Japan Union Hospital of Jilin University) ;
  • Yifa Zhou (School of Life Sciences, Northeast Normal University) ;
  • Xianling Cong (Department of Biobank, China-Japan Union Hospital of Jilin University) ;
  • Miao Hao (Scientific Research Center, China-Japan Union Hospital of Jilin University)
  • Received : 2022.08.22
  • Accepted : 2023.04.18
  • Published : 2023.09.01
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Abstract

Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, anti-oxidation, anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane, oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on the sugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD) and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play antiaging roles by enhancing immune function, resisting melanin formation, inhibiting oxidation, and elevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously been widely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skin aging process from mechanisms and experimental research.

Keywords

Acknowledgement

This research was supported by Department of Science and Technology of Jilin Province (grant no. YDZJ202201ZYTS021, 20190103086JH).

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