Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
권호 표지
DOI QR코드

DOI QR Code

NADH-Reductive Stress in Cancer Cell Proliferation Regulation of the NADH/NAD+ ratio via NRF2-mediated ALDH3A1 upregulation

  • Dahee Choi (Division of Life Sciences, Korea University)
  • Received : 2023.06.01
  • Accepted : 2023.07.03
  • Published : 2023.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

Acknowledgement

I would like to thank Prof. Seung-Hoi Koo (Korea University) for valuable comments. This work is supported by a grant from Korea University.

References

  1. Ghanbari Movahed, Z., Rastegari-Pouyani, M., Mohammadi, M.H., and Mansouri, K. (2019). Cancer cells change their glucose metabolism to overcome increased ROS: one step from cancer cell to cancer stem cell? Biomed. Pharmacother. 112, 108690.
  2. Harris, I.S. and DeNicola, G.M. (2020). The complex interplay between antioxidants and ROS in cancer. Trends Cell Biol. 30, 440-451. https://doi.org/10.1016/j.tcb.2020.03.002
  3. Holmstrom, K.M., Kostov, R.V., and Dinkova-Kostova, A.T. (2016). The multifaceted role of Nrf2 in mitochondrial function. Curr. Opin. Toxicol. 1, 80-91. https://doi.org/10.1016/j.cotox.2016.10.002
  4. Lin, C.Y., Loven, J., Rahl, P.B., Paranal, R.M., Burge, C.B., Bradner, J.E., Lee, T.I., and Young, R.A. (2012). Transcriptional amplification in tumor cells with elevated c-Myc. Cell 151, 56-67. https://doi.org/10.1016/j.cell.2012.08.026
  5. Martinez-Reyes, I. and Chandel, N.S. (2020). Mitochondrial TCA cycle metabolites control physiology and disease. Nat. Commun. 11, 102.
  6. Quintana, A., Kruse, S.E., Kapur, R.P., Sanz, E., and Palmiter, R.D. (2010). Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome. Proc. Natl. Acad. Sci. U. S. A. 107, 10996-11001. https://doi.org/10.1073/pnas.1006214107
  7. Weiss-Sadan, T., Ge, M., Hayashi, M., Gohar, M., Yao, C.H., de Groot, A., Harry, S., Carlin, A., Fischer, H., Shi, L., et al. (2023). NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab. 35, 487-503.e7. https://doi.org/10.1016/j.cmet.2023.01.012
  8. Wu, S., Lu, H., and Bai, Y. (2019). Nrf2 in cancers: a double-edged sword. Cancer Med. 8, 2252-2267. https://doi.org/10.1002/cam4.2101
  9. Xiao, W. and Loscalzo, J. (2020). Metabolic responses to reductive stress. Antioxid. Redox Signal. 32, 1330-1347.  https://doi.org/10.1089/ars.2019.7803