대한소아치과학회지 (Journal of the korean academy of Pediatric Dentistry)

  • 제50권3호
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  • Pages.334-346
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  • 2023
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  • 1226-8496(pISSN)
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  • 2288-3819(eISSN)
대한소아치과학회 (Korean Academy of Pediatric Dentistry)
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골 성숙도 결정 시 혈청 IGF-1, IGFBP-3 농도와 수완부 방사선 사진의 상관관계

Correlation between Serum IGF-1, IGFBP-3 Levels, and Hand-Wrist Radiographs in Determining Skeletal Maturity

  • 곽미선 (아주대학교 치과병원 소아치과) ;
  • 마연주 (아주대학교 치과병원 소아치과)
  • Misun Kwak (Department of Pediatric Dentistry, Dental Hospital, Ajou University) ;
  • Yon-joo Mah (Department of Pediatric Dentistry, Dental Hospital, Ajou University)
  • 투고 : 2023.06.03
  • 심사 : 2023.07.22
  • 발행 : 2023.08.31
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⟨ 이전 논문 다음 논문 ⟩

초록

이 연구의 목적은 Skeletal maturity indicator (SMI) 및 Middle phalanx of the third finger (MP3)와 혈청 Insulin-like growth factor-1 (IGF-1) 및 Insulin-like growth factor binding protein-3 (IGFBP-3)의 상관 관계를 통해 골격적 성숙도의 예측 지표로 사용될 수 있는지 알아보는 것이다. 2018년 1월부터 2022년 12월까지 아주대학교 치과병원 및 소아청소년과에 내원한 만 7세 이상 17세 이하 환자 205명의 의무기록을 후향적으로 분석하였다. 혈청 IGF-1 농도는 SMI 6 - 8, MP3 - G에서 가장 높았고(p < 0.0001) 혈청 IGFBP-3 농도는 SMI 9 - 10, MP3 - I에서 가장 높았다(p = 0.010, 0.030). SMI, MP3와 혈청 IGF-1 농도 간 비교적 높은 Pearson 상관계수를 나타냈다(r = 0.698, 0.622, p < 0.0001). 혈청 IGF-1는 소아청소년의 골격적 성숙도를 평가하는 보조적 수단으로 활용될 수 있을 것이며 임상적으로는 472 ㎍/L에서 510.63 ㎍/L의 범위를 최대성장기로 고려할 수 있다.

The aim of this study was to assess the correlation between serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and hand-wrist radiographs using a skeletal maturity indicator (SMI) and the middle phalanx of the third finger (MP3). Hand-wrist radiographs and blood samples from 205 patients aged 7 - 17 years were retrospectively analyzed by two dentists using the SMI stages, MP3 stages, and serum IGF-1 and IGFBP-3 levels. Serum IGF-1 levels were highest at the SMI 6 - 8 and MP3 - G stage and lowest at the SMI 1 - 3 and MP3 - F stage (p < 0.0001). Serum IGFBP-3 levels were highest at the SMI 9 - 10 and MP3 - I stage and lowest at the SMI 1 - 3 and MP3 - FG stage (p = 0.010, 0.030). As a result of Pearson correlation analysis, a relatively high correlation was found between skeletal maturity using the SMI and MP3 stages and serum IGF-1 levels (r = 0.698, 0.622, p < 0.0001). According to the results of this study, serum IGF-1 levels can be used as an auxiliary measure to evaluate the skeletal maturity of children and adolescents in dentistry. The range from the mean serum IGF-1 level of 472 ㎍/L in SMI 6 stage to the mean IGF-1 level of 510.63 ㎍/L in MP3 G stage could be considered as the peak height velocity in clinical practice.

키워드

참고문헌

  1. Flores-Mir C, Nebbe B, Major PW : Use of skeletal maturation based on hand-wrist radiographic analysis as a predictor of facial growth: a systematic review. Angle Orthod, 74:118-124, 2004.
  2. Bagherpour A, Pousti M, Adelianfar E : Hand skeletal maturity and its correlation with mandibular dental development. J Clin Exp Dent, 6:E275-E279, 2014. https://doi.org/10.4317/jced.51433
  3. Park KT : Practical Approaches in Early Orthodontic Treatment, 3rd ed. Daehan Narae Publishing House, Seoul, 85-87, 2021.
  4. Baccetti T, Franchi L, De Toffol L, Ghiozzi B, Cozza P : The diagnostic performance of chronologic age in the assessment of skeletal maturity. Prog Orthod, 7:176-188, 2006.
  5. Moore RN, Moyer BA, DuBois LM : Skeletal maturation and craniofacial growth. Am J Orthod Dentofacial Orthop, 98:33-40, 1990. https://doi.org/10.1016/0889-5406(90)70029-C
  6. Bjork A, Helm S : Prediction of the age of maximum puberal growth in body height. Angle Orthod, 37:134-143, 1967.
  7. Chapman SM : Ossification of the adductor sesamoid and the adolescent growth spurt. Angle Orthod, 42:236-244, 1972.
  8. Fishman LS : Radiographic evaluation of skeletal maturation. A clinically oriented method based on handwrist films. Angle Orthod, 52:88-112, 1982.
  9. Hagg U, Taranger J : Maturation indicators and the pubertal growth spurt. Am J Orthod, 82:299-309, 1982. https://doi.org/10.1016/0002-9416(82)90464-X
  10. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC : Growth hormone and bone. Endocr Rev, 19:55-79, 1998. https://doi.org/10.1210/edrv.19.1.0324
  11. Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L : Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab, 35:665-670, 1972. https://doi.org/10.1210/jcem-35-5-665
  12. Juul A, Skakkebaek NE : Prediction of the outcome of growth hormone provocative testing in short children by measurement of serum levels of insulin-like growth factor I and insulin-like growth factor binding protein 3. J Pediatr, 130:197-204, 1997. https://doi.org/10.1016/S0022-3476(97)70343-3
  13. Je YS, Jang WR, Nahm CH, Choi JW, Kim JJ, Kim SK, Lee JE, Hyun IY, Moon Y : Usefulness of serum IGF-I and IGFBP-3 levels in children with short stature. J Lab Med Qual Assur, 36:48-53, 2014. https://doi.org/10.15263/jlmqa.2014.36.1.48
  14. Loche S, Casini MR, Faedda A : The GH/IGF-I axis in puberty. Br J Clin Pract Suppl, 85:1-4, 1996.
  15. Schoenle E, Zapf J, Humbel RE, Froesch ER : Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature, 296:252-253, 1982. https://doi.org/10.1038/296252a0
  16. Almalki A, Thomas JT, Khan ARA, Almulhim B, Alassaf A, Alghamdi SA, Joseph B, Alqerban A, Alotaibi S : Correlation between salivary levels of IGF-1, IGFBP-3, IGF-1/IGFBP3 ratio with skeletal maturity using hand-wrist radiographs. Int J Environ Res Public Health, 19:3723, 2022.
  17. Toia M, Galazzo R, Maioli C, Granata R, Scarlatti F : The IGF-I/IGFBP-3 system in gingival crevicular fluid and dependence on application of fixed force. J Endocrinol Invest, 28:1009-1014, 2005. https://doi.org/10.1007/BF03345340
  18. Phogat R, Sidhu MS, Grover S, Dabas A, Malik V, Diwakar R : Comparative evaluation of efficiency of serum IGF-1, hand-wrist radiographs, and cervical vertebrae as skeletal maturity indicator. J Indian Orthodont Soc, 49:199-205, 2015. https://doi.org/10.4103/0301-5742.171305
  19. Masoud MI, Masoud I, Kent Jr RL, Gowharji N, Hassan AH, Cohen LE : Relationship between blood-spot insulin-like growth factor 1 levels and hand-wrist assessment of skeletal maturity. Am J Orthod Dentofacial Orthop, 136:59-64, 2009. https://doi.org/10.1016/j.ajodo.2007.07.023
  20. Gupta S, Jain S, Gupta P, Deoskar A : Determining skeletal maturation using insulin-like growth factor I (IGF-I) test. Prog Orthod, 13:288-295, 2012. https://doi.org/10.1016/j.pio.2011.09.006
  21. Jain N, Tripathi T, Gupta SK, Rai P, Kanase A, Kalra S : Serum IGF-1, IGFBP-3 and their ratio: potential biochemical growth maturity indicators. Prog Orthod, 18:11, 2017.
  22. Bjork A : Timing of interceptive orthodontic measures based on stages of maturation. Trans Eur Orthod Soc, 61-74, 1972.
  23. Burstone CJ : Process of maturation and growth prediction. Am J Orthod Dentofac Orthop, 49:907-919, 1963. https://doi.org/10.1016/0002-9416(63)90220-3
  24. Kim SJ, Song JS, Kim IH, Kim SO, Choi HJ : Correlation between dental and skeletal maturity in Korean children. J Korean Acad Pediatr Dent, 48:255-268, 2021. https://doi.org/10.5933/JKAPD.2021.48.3.255
  25. Lee YJ, Mah YJ : Skeletal age assessment of SMI and MP3 stages to predict the pubertal growth spurt. J Korean Acad Pediatr Dent, 46:233-238, 2019. https://doi.org/10.5933/JKAPD.2019.46.3.233
  26. Yoo HK, Ra JY, Lee JW : Skeletal maturity evaluation using maxillary canine development in growing children. J Korean Acad Pediatr Dent, 46:247-254, 2019. https://doi.org/10.5933/JKAPD.2019.46.3.247
  27. Sato K, Mito T, Mitani H : An accurate method of predicting mandibular growth potential based on bone maturity. Am J Orthod Dentofacial Orthop, 120:286-293, 2001. https://doi.org/10.1067/mod.2001.115932
  28. Van Erum R, Mulier G, Carels C, de Zegher F : Craniofacial growth and dental maturation in short children born small for gestational age: effect of growth hormone treatment. Own observations and review of the literature. Horm Res, 50:141-146, 1998. https://doi.org/10.1159/000023262
  29. Funatsu M, Sato K, Mitani H : Effects of growth hormone on craniofacial growth. Angle Orthod, 76:970-977, 2006. https://doi.org/10.2319/011905-17
  30. Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D : Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest, 110:771-781, 2002. https://doi.org/10.1172/JCI0215463
  31. Juul A, Dalgaard P, Blum WF, Bang P, Hall K, Michaelsen KF, Muller J, Skakkebaek NE : Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab, 80:2534-2542, 1995. https://doi.org/10.1210/jcem.80.8.7543116
  32. Grave KC, Brown T : Skeletal ossification and the adolescent growth spurt. Am J Orthod, 69:611-619, 1976. https://doi.org/10.1016/0002-9416(76)90143-3
  33. Muddaiah S, Bharath S, Goutham B, Suhailuddin, Susil V, Nanu N : Assessment of Relationship Between Insulin-Like Growth Factor-1 Levels And Mp3 Radiographs in Determining Skeletal Maturity. J Multidiscip Dent Res, 5:22-27, 2019. https://doi.org/10.38138/JMDR/v5i1.4
  34. Song AK, Kim HJ, Suk HJ, Hwang JS, Hong CH : Serum IGF-I and IGFBP-3 in 919 healthy Korean children and adolescents: normal values and correlations with age, sex, height, body mass index and bone age. J Korean Soc Pediatr Endocrinol, 10:35-41, 2005.
  35. Yang GH, Jung HL, Kim DS, Shim JW, Shim JY, Park MS : Evaluation of serum insulin-like growth factor(IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 levels in healthy korean children. Korean J Pediatr, 48:298-305, 2005.
  36. Chung YH, Chung WY : Serum levels of free insulin-like growth factor-I and clinical value in healthy children. Korean J Pediatr, 51:47-53, 2008. https://doi.org/10.3345/kjp.2008.51.1.47
  37. Masoud M, Masoud I, Kent RL Jr, Gowharji N, Cohen LE : Assessing skeletal maturity by using blood spot insulin-like growth factor I (IGF-I) testing. Am J Orthod Dentofacial Orthop, 134:209-216, 2008. https://doi.org/10.1016/j.ajodo.2006.09.063
  38. Mitani H, Sato K, Sugawara J : Growth of mandibular prognathism after pubertal growth peak. Am J Orthod Dentofacial Orthop, 104:330-336, 1993. https://doi.org/10.1016/S0889-5406(05)81329-0
  39. Choi HK, Kong MH, Ahn BH, Kim SM, Lee DJ, Kim KM : Insulin-like growth factor 1 level and its relating factor in Korean healthy adults. Korean J Fam Med, 30:15-22, 2009. https://doi.org/10.4082/kjfm.2009.30.1.15
  40. Sookhakian A, Zahed M, Pakshir H, Ajami S : Salivary IGF-1 and alkaline phosphatase-based modeling for skeletal maturity prediction in orthodontic patients. Biomed Res Int, 2022:2390865, 2022.