DOI QR코드

DOI QR Code

Disulfidptosis: Disulfide Stress Mediates a Novel Cell Death Pathway via Actin Cytoskeletal Vulnerability

  • Dongpu Shao (Department of Cardiology, The First Hospital of Jilin University) ;
  • Lei Shi (Department of Cardiology, The First Hospital of Jilin University) ;
  • Honglei Ji (Department of Cardiology, The First Hospital of Jilin University)
  • 투고 : 2023.04.19
  • 심사 : 2023.04.21
  • 발행 : 2023.07.31

초록

키워드

과제정보

Grants from the National Natural Science Foundation of China (81974027) supported the work.

참고문헌

  1. Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., Skouta, R., Zaitsev, E.M., Gleason, C.E., Patel, D.N., Bauer, A.J., Cantley, A.M., Yang, W.S., et al. (2012). Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060-1072. https://doi.org/10.1016/j.cell.2012.03.042
  2. Liu, X., Nie, L., Zhang, Y., Yan, Y., Wang, C., Colic, M., Olszewski, K., Horbath, A., Chen, X., Lei, G., et al. (2023). Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat. Cell Biol. 25, 404-414. https://doi.org/10.1038/s41556-023-01091-2
  3. Liu, X., Olszewski, K., Zhang, Y., Lim, E.W., Shi, J., Zhang, X., Zhang, J., Lee, H., Koppula, P., Lei, G., et al. (2020). Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat. Cell Biol. 22, 476-486. https://doi.org/10.1038/s41556-020-0496-x
  4. Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R.D., et al. (2022). Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375, 1254-1261.  https://doi.org/10.1126/science.abf0529