Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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The Pleiotropic Face of CREB Family Transcription Factors

  • Md. Arifur Rahman Chowdhury (Division of Life Sciences (Molecular Biology Major), Department of Bioactive Material Sciences, and Research Center of Bioactive Materials, Jeonbuk National University) ;
  • Jungeun An (Division of Life Sciences (Life Sciences Major), Jeonbuk National University) ;
  • Sangyun Jeong (Division of Life Sciences (Molecular Biology Major), Department of Bioactive Material Sciences, and Research Center of Bioactive Materials, Jeonbuk National University)
  • Received : 2022.12.22
  • Accepted : 2023.02.07
  • Published : 2023.07.31
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Abstract

cAMP responsive element-binding protein (CREB) is one of the most intensively studied phosphorylation-dependent transcription factors that provide evolutionarily conserved mechanisms of differential gene expression in vertebrates and invertebrates. Many cellular protein kinases that function downstream of distinct cell surface receptors are responsible for the activation of CREB. Upon functional dimerization of the activated CREB to cis-acting cAMP responsive elements within the promoters of target genes, it facilitates signal-dependent gene expression. From the discovery of CREB, which is ubiquitously expressed, it has been proven to be involved in a variety of cellular processes that include cell proliferation, adaptation, survival, differentiation, and physiology, through the control of target gene expression. In this review, we highlight the essential roles of CREB proteins in the nervous system, the immune system, cancer development, hepatic physiology, and cardiovascular function and further discuss a wide range of CREB-associated diseases and molecular mechanisms underlying the pathogenesis of these diseases.

Keywords

Acknowledgement

We thank Md. Mazedul Haq for critical reading of the manuscript. This research was supported by a grant from the National University Promotion Program at Jeonbuk National University provided in 2021.

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