한국섬유공학회지 (Textile Science and Engineering)

  • 제60권3호
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  • Pages.187-193
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  • 2023
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  • 1225-1089(pISSN)
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  • 2288-6419(eISSN)
한국섬유공학회 (The Korean Fiber Society)
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비용매 유도 상전이법을 이용한 혈액투석막의 제조 및 분리 특성 평가

Manufacturing and Separation Characteristics Evaluation of Hemodialysis Membrane Using NIPS

  • 이경태 (건양대학교 의료신소재학과) ;
  • 오도창 (건양대학교 의공학과) ;
  • 홍영기 (건양대학교 의료신소재학과)
  • Gyeong Tae Lee (Department of Biomedical Materials, Konyang University) ;
  • Do Chang Oh (Department of Biomedical Engineering, Konyang University) ;
  • Young Ki Hong (Department of Biomedical Materials, Konyang University)
  • 투고 : 2023.04.24
  • 심사 : 2023.05.27
  • 발행 : 2023.06.30
⟨ 이전 논문 다음 논문 ⟩

초록

Hemodialysis is one of the most common kidney replacement methods such as kidney transplantation and peritoneal dialysis for patients with kidney disease such as renal failure. In this study, a polymer solution containing polyethersulfone(PES) as the main raw material and polyvinylpyrrolidone(PVP), a hydrophilic polymer, was prepared by using different types of non-solvent when manufacturing hemodialysis membranes using the non-solvent induced phase separation(NIPS) method. The characteristics of the manufactured hemodialysis membrane were analyzed through ATR-FTIR and SEM, and the separation charateristics of the hemodialysis membrane were evaluated by performing simulated dialysis using artificial blood and dialysate. As a result, the chemical structure of the manufactured hemodialysis membranes did not change depending on the type of non-solvent, and in the case of the cross-sectional structure, a finger-like structure and a sponge structure were confirmed according to the non-solvent. The maximum removal rate of toxic materials were Urea 56.97% and Creatinine 52.71%, and protein loss was less than 6%. In addition, cell viability was evaluated as up to 92.4%. The biocompatibility and functionality of the hemodialysis membrane made of PES were confirmed.

키워드

과제정보

이 논문은 2022학년도 건양대학교 학술연구비 지원에 의하여 이루어진 것임.

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