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Non-derivatizing Tandem Mass Spectrometry Assay for Expanded Newborn Screening and Cutoffs for Preterm Neonates

  • Joon Hee Lee (Department of Laboratory Medicine, Seoul National University Bundang Hospital) ;
  • Junghan Song (Department of Laboratory Medicine, Seoul National University College of Medicine)
  • Published : 2023.03.01

Abstract

Keywords

References

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  2. Rappold BA. Review of the use of liquid chromatography-tandem mass spectrometry in clinical laboratories: Part II-Operations. Ann Lab Med 2022;42:531-57. https://doi.org/10.3343/alm.2022.42.5.531
  3. Chace DH, Kalas TA, Naylor EW. The application of tandem mass spectrometry to neonatal screening for inherited disorders of intermediary metabolism. Annu Rev Genomics Hum Genet 2002;3:17-45. https://doi.org/10.1146/annurev.genom.3.022502.103213
  4. Wilcken B, Wiley V, Hammond J, Carpenter K. Screening newborns for inborn errors of metabolism by tandem mass spectrometry. N Engl J Med 2003;348:2304-12. https://doi.org/10.1056/NEJMoa025225
  5. Zytkovicz TH, Fitzgerald EF, Marsden D, Larson CA, Shih VE, Johnson DM, et al. Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program. Clin Chem 2001; 47:1945-55. https://doi.org/10.1093/clinchem/47.11.1945
  6. Lee B, Heo WY, Kim JA, Lee HS, Hwang N, Park HD, et al. Comprehensive evaluation of the NeoBase 2 non-derivatized MSMS assay with exploration of analytes with significantly different levels between term and preterm neonates. Ann Lab Med 2023;43:153-66. https://doi.org/10.3343/alm.2023.43.2.153