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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Clinical features and molecular mechanism of muscle wasting in end stage renal disease

  • Sang Hyeon Ju (Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Hyon-Seung Yi (Department of Internal Medicine, Chungnam National University School of Medicine)
  • Received : 2023.06.07
  • Accepted : 2023.07.17
  • Published : 2023.08.31
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Abstract

Muscle wasting in end-stage renal disease (ESRD) is an escalating issue due to the increasing global prevalence of ESRD and its significant clinical impact, including a close association with elevated mortality risk. The phenomenon of muscle wasting in ESRD, which exceeds the rate of muscle loss observed in the normal aging process, arises from multifactorial processes. This review paper aims to provide a comprehensive understanding of muscle wasting in ESRD, covering its epidemiology, underlying molecular mechanisms, and current and emerging therapeutic interventions. It delves into the assessment techniques for muscle mass and function, before exploring the intricate metabolic and molecular pathways that lead to muscle atrophy in ESRD patients. We further discuss various strategies to mitigate muscle wasting, including nutritional, pharmacological, exercise, and physical modalities intervention. This review seeks to provide a solid foundation for future research in this area, fostering a deeper understanding of muscle wasting in ESRD, and paving the way for the development of novel strategies to improve patient outcomes.

Keywords

Acknowledgement

This work was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HR22C1734). H-SY was supported by the Basic Science Research Program, through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning, Republic of Korea (NRF-2023R1A2C3006220).

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