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A Study on the Clinical Study of Herbal Medicine for Postmenopausal Osteoporosis

폐경기 골다공증에 대한 한약 임상 연구 고찰

  • Young-Eun Kim (Dept. of Korean Medicine OB & GY, Pusan National University Korean Medicine Hospital) ;
  • Hee-Yoon Lee (Dept. of Korean Medicine OB & GY, Pusan National University Korean Medicine Hospital) ;
  • Jang-Kyung Park (Dept. of Korean Medicine OB & GY, Pusan National University Korean Medicine Hospital) ;
  • Young-Jin Yoon (Dept. of Korean Medicine OB & GY, Pusan National University Korean Medicine Hospital)
  • 김영은 (부산대학교 한방병원 한방부인과) ;
  • 이희윤 (부산대학교 한방병원 한방부인과) ;
  • 박장경 (부산대학교 한방병원 한방부인과) ;
  • 윤영진 (부산대학교 한방병원 한방부인과)
  • Received : 2023.07.13
  • Accepted : 2023.08.25
  • Published : 2023.08.25

Abstract

Objectives: The purpose of this study is to report the clinical effectiveness and safety of herbal medicine treatment for postmenopausal osteoporosis. Methods: Researchers searched papers through 5 online databases including The Cochrane Library Central, Pubmed, China Academic Journal (CAJ), Oriental medicine Advanced Searching Integrated System (OASIS) and Korean studies Information Service System (KISS). Randomized controlled trials (RCTs) that used herbal medicine as treatment were included. Results: Twenty three studies were selected by the selection and exclusion criteria. The treatment group was treated with herbal medicine alone or with herbal medicine and conventional medicine. The control group was treated with conventional medicine. Most common evaluation index was Bone Mineral Density (BMD) followed by total efficacy rate and level of bone metabolism markers, level of sex hormones, etc. Compared with the control group, the treatment group was more effective and safer in all of 23 studies. Conclusions: Herbal treatment alone could be an effective and safe option in treating postmenopausal osteoporosis. Moreover herbal treatment with conventional medicine could improve its therapeutic effect on postmenopausal osteoporosis as well.

Keywords

Acknowledgement

이 과제는 부산대학교 기본연구지원사업(2년)에 의하여 연구되었음

References

  1. The Society of Oriental Obstetrics & Gynecology. Korean Medicine Obstetrics & Gynecology. Vol. 2. 3th rev. ed. Seoul: Euiseongdang. 2016:228-59.
  2. Korean Society Of Menopause. Management of menopausal women. 5th rev. ed. Seoul:Gabon medical book. 2020:1-20, 59-71.
  3. Korean Society Of Gynecologic Endocrinology. Gynecologic Endocrinology. 2nd rev. ed. Paju:KoonJa Publishing Co. 2022:543-80.
  4. Yoon SH, Kim JG. Current Treatment of Postmenopausal Osteoporosis. Korean Journal of Obstetrics and Gynecology. 2005;48(4):844-5.
  5. Won JY, et al. Effect of Herbal Medicine on Osteoporosis: A Review of Animal Experiment, Clinical Studies Published in Korea and Overseas. Journal of oriental rehabilitation medicine. 2021;31(3):31-55. https://doi.org/10.18325/jkmr.2021.31.3.31
  6. Lee JM, Kim NH, Lee EJ. Review on Korean Herbal Medicine Complex Prescriptions and Single Herbal Medicines for Osteoporosis - Focused on Domestic Research Published Since 2013. Jounal of Physiology & Pathology in Korean Medicine. 2021;35(3):87-96. https://doi.org/10.15188/kjopp.2021.06.35.3.87
  7. Ning J, et al. Efficacy of Self-Formulated Traditional Chinese Medicine Zhuangshen Bugu Recipe as an Adjunctive Treatment for Postmenopausal Osteoporosis: Effects on Serum Hormones and Bone Metabolic Markers(自拟中药壮肾补骨方辅助治疗绝经后骨质疏松症的疗效及血清性激素和骨代谢指标变化). Shangdong Medical Journal. 2022;62(29):74-7.
  8. He C, et al. Application of Yiqi Wenjing Decotion in treatment of kidney-deficiency -blood-stasis-type postmenopausal osteoporosis: a clinical study(益气温经方在绝经后骨质疏松症肾虚血瘀证治疗中的应用). The Journal of Traditional Chinese Orthopedics and Traumatology. 2021;33(8):7-11, 15.
  9. Guo J, et al. Clinical Study of Traditional Chinese Medicine Prescription Combined with Alendronate in the Treatment of Postmenopausal Osteoporosis(中药组方联合阿伦磷酸钠治疗绝经后骨质疏松症的临床研究). Evaluation and Analysis of Drug-Use in Hospitals of China. 2021;21(9):1057-60.
  10. Wu J, Juang T. Clinical Efficacy of Modified Ziyin Busui Decoction Combined with Caltrate D and Alfacalcidol Soft Capsules in Treating Postmenopausal Osteoporosis(滋阴补髓汤加减与钙尔奇D及阿法骨化醇软胶囊联合治疗绝经后骨质疏松症的临床疗效研究). Journal of Guangzhou University of Traditional Chinese Medicine. 2020;37(9):1662-7.
  11. Lu J. Clinical Effects of Integrated Traditional Chinese and Western Medicine Treatment for Postmenopausal Osteoporosis in Elderly Women(老年女性慢性绝经性骨质疏松症中西医结合治疗临床效果). Maternal and Child Health Care of China. 2020;35(22):4168-70.
  12. Tang X, et al. Clinical Observation of Bushen Huoxue Recipe in the Treatment of Postmenopausal Osteoporosis with Liver and Kidney Deficiency Syndrome(补肾活血方治疗肝肾亏虚型绝经后骨质疏松症临床观察). Clinical Journal of Traditional Chinese Medicine. 2020;32(3):523-5.
  13. Cang Y, et al. Clinical effect of Zhuanggu Tablet in Treating Postmenopausal Kidney Deficiency Osteoporosis(壮骨片治疗绝经后肾虚型骨质疏松症的临床疗效研究). Clinical Journal of Traditional Chinese Medicine. 2020;32(3):532-5.
  14. Chen L, et al. Effect of Buguqiangjin Recipe on Peri-menopausal Osteoporosis and Its Influence on Sex Hormone and Inflammatory Factors(补骨强筋方治疗围绝经期骨质疏松症的疗效及对性激素, 炎症因子的影响). Medical Innovation of China. 2019;16(36):45-9.
  15. Wang X. Clinical Observation of the Combined Treatment of Bushen Huoxue Decoction with Caltrate in 100 Cases of Postmenopausal Primary Osteoporosis (补肾活血汤联合钙尔奇治疗绝经后原发性骨质疏松症100例临床观察). Chinese Journal of Ethnomedicine and Ethnopharmacy. 2018;27(24):127-9.
  16. Dong Z, et al. Study on the Effects of Jiawei Guilu Yanggu Decoction Combined with Parathyroid Hormone on the Body Composition of Patients with Postmenopausal Osteoporosis(加味龟鹿养骨汤联合甲状旁腺激素对绝经后骨质疏松患者身体成分的影响). World Chinese Medicine. 2018;13(2):393-5, 399.
  17. Huang H. Analysis of the Combined Traditional Chinese and Western Medicine Treatment for Perimenopausal and Postmenopausal Women with Osteoporosis(中西医结合治疗围绝经期及绝经期妇女骨质疏松症分析). China Practical Medicine. 2018;13(3):118-9.
  18. Huang L. Clinical study on Bushen Zhuanggu method in the treatment of postmenopausal osteoporosis(补肾壮骨法治疗绝经后骨质疏松症的临床研究). China Practical Medicine. 2017;12(10):21-3.
  19. Xie L, et al. Effects of Yigu Decotion on Serum E2 Level and Anxiety of Postmenopausal Osteoporosis Women (益骨汤对绝经后骨质疏松患者雌激素水平及情志的影响). Chinese Journal of Traditional Medical Science and Technology. 2017;24(6):690-3.
  20. Zhang B, Wang X, Hao T. Clinical Observation of Traditional Chinese Medicine Treatment for Postmenopausal Osteoporosis(绝经后骨质疏松症的临床中药治疗观察). Journal of Podiatry and Health. 2017;16(19):180-1.
  21. Zhou J, et al. Clinical Study of Traditional Chinese Medicine Treatment for Postmenopausal Osteoporosis with Bushen Huoxue Therapy(补肾活血中药治疗绝经后骨质疏松症临床研究). Zhejiang Journal of Integrated Traditional Chinese and Western Medicine. 2017;27(5):398-400.
  22. Wang S, Dai H. Analysis of the Therapeutic Effect of DuHuoJiSheng-Tang as an Adjunctive Treatment for Postmenopausal Osteoporosis(独活寄生汤辅助治疗绝经后骨质疏松症疗效分析). Guizhou Medical Journal. 2017;41(1):65-6.
  23. Dong C, et al. Clinical Study on the Therapeutic Effect of Bushen Zhuanggu Decoction for Postmenopausal Osteoporosis with Liver and Kidney Yin Deficiency Syndrome(补肾壮骨汤治疗绝经后肝肾阴虚型骨质疏松症的临床疗效研究). World Latest Medicine Information. 2017;17(A0):169, 179.
  24. Zhong Q, et al. Observation of the Clinical Efficacy on Post - Menopausal Osteoporosis Treated with Jianpi Yiqi Formula(健脾益气方对绝经后女性骨质疏松症的临床疗效观察). World Journal of Integrated Traditional and Western Medicine. 2015;10(3):378-80.
  25. Fu Y. Clinical Evaluation of Traditional Chinese Medicine Treatment for Postmenopausal Osteoporosis(中药治疗绝经后骨质疏松症的临床疗效评价). Journal of Community Medicine. 2015;13(7):31-2, 41.
  26. Zhong Y, Zhang Y, Bao F. Clinical Observation of Combined Traditional Chinese and Western Medicine Treatment for Postmenopausal Osteoporosis(中西药结合治疗绝经后骨质疏松症临床观察). Journal of New Chinese Medicine. 2015;47(1):145-7.
  27. Wang Y. Combined Traditional Chinese and Western Medicine Treatment for 40 Cases of Postmenopausal Osteoporosis (中西医结合治疗绝经期骨质疏松症40例). Chinese Medicine Modern Distance Education of China. 2014;12(5):63-4.
  28. Li T. Clinical Study of Modified LiuWeiDiHuang-Wan in the Treatment of Postmenopausal Osteoporosis with Liver and Kidney Yin Deficiency Syndrome(六味地黄丸加味治疗肝肾阴虚证绝经后骨质疏松症临床研究). Journal of Medical Forum. 2014;35(8):160-2.
  29. Diao W, et al. Effect of Yangxue Gushen Decoction on Pain Score and Bone Mineral Density of Women with Postmenopausal Osteoporosis (养血固肾汤对绝经后骨质疏松症患者疼痛评分和骨密度的影响). Journal of New Chinese Medicine. 2013;45(6):64-6.
  30. Health Insurance Review and Assessment Service. Statistics on diseases of national interest - Osteoporosis [serial online] 2017Jan-2021 December [cited 2023 July 6]. Available from:URL:https://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfoTab1.do
  31. The Society of Korean Medicine Acupuncture & Moxibustion. Clinical Practice Guideline of Korean Medicine - Osteoporosis. Seoul:Pan Mun Education Publishing Co. 2022:46-55.
  32. Textbook compliation committee. Herbal medicine. 2rd rev. ed. Seoul:Younglimsa. 2007:10-8, 632-3, 687-8.
  33. Jeon YK, Kim IJ. Pharmacological treatment of osteoporosis. Journal of the Korean Medical Association. 2022;65(4):241-8. https://doi.org/10.5124/jkma.2022.65.4.241