Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
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Development of Chemical Separation Process for Thallium-201 Radioisotope with Lead Standard Material

납 표준물질을 이용한 방사성동위원소 Thallium-201의 화학적 분리공정 개발

  • JunYoung Lee (Accelerator Radioisotope Research Section, Korea Atomic Energy Research Institute) ;
  • TaeHyun Kim (Accelerator Radioisotope Research Section, Korea Atomic Energy Research Institute) ;
  • JeongHoon Park (Accelerator Radioisotope Research Section, Korea Atomic Energy Research Institute)
  • 이준영 (한국원자력연구원 가속기동위원소연구실) ;
  • 김태현 (한국원자력연구원 가속기동위원소연구실) ;
  • 박정훈 (한국원자력연구원 가속기동위원소연구실)
  • Received : 2023.12.01
  • Accepted : 2023.12.11
  • Published : 2023.12.31
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Abstract

Thallium-201 (201Tl) is a medical radioisotope which emits gamma rays when it decays and used in myocardial perfusion scans in single-photon emission tomography due to its similar properties to potassium. Currently, the Korea Institute of Radiological & Medical Sciences is the only institution producing 201Tl in Korea, and optimization of 201Tl production research is necessary to meet supply compared to domestic demand. To this end, technical analysis of plating target production and chemical separation methods essential for 201Tl production research is conducted. It deals with the process of generating and separating 201Tl radioisotope and target production, It can be generated through a nuclear reaction such as natHg(p,xn)201Tl, 201Hg(p,n)201Tl, natPb(p,xn)201Bi → 201Pb → 201Tl, 205Tl(p,5n)201Pb → 201Tl, and considering impure nuclide generated simultaneously with the use of proton beam energy of 35 MeV or less, it is intended to be produced using the 203Tl(p,3n)201Pb→201Tl nuclear reaction. In particular, the chemical separation of Tl is a very important element, and the chemical separation methods that can separate it is broadly divided into four types, including solid phase extraction, liquid-liquid, electrochemical, and ion exchange membrane separation. Some chemical separations require additional separation steps, such as methods using selective adsorption. Therefore, this technical report describes four chemical separation methods and seeks to separate high-purity 201Tl using a method without additional separation steps

Keywords

Acknowledgement

본 연구는 과학기술정보통신부의 재원으로 한국원자력연구원 주요사업(수출형 35 MeV 사이클로트론 시스템 개발, 523530-23)의 일환으로 수행되었습니다.

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