BMB Reports

생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1

  • Jiyoung Park (College of Pharmacy, Chung-Ang University) ;
  • Sewoong Lee (College of Pharmacy, Chung-Ang University) ;
  • Haelim Yoon (College of Pharmacy, Chung-Ang University) ;
  • Eunjeong Kang (College of Pharmacy, Chung-Ang University) ;
  • Sayeon Cho (College of Pharmacy, Chung-Ang University)
  • 투고 : 2023.01.30
  • 심사 : 2023.06.20
  • 발행 : 2023.07.31
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초록

Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers.

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과제정보

This research was supported by National Research Foundation of Korea (NRF) grants, funded by the Korea government (MSIT) (2021R1A2C1011196 and 2021M3A9G8024747) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1A6A1A03044296). The chemical used in this study was kindly provided by Korea Chemical Bank (www.chembank.org) of Korea Research Institute of Chemical Technology.

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