Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-Inflammatory Effect of Vitamin D via Suppression of YKL-40 Production: One of the Possible Mechanisms for Cardiovascular Protection

  • Hack-Lyoung Kim (Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine)
  • Received : 2023.01.26
  • Accepted : 2023.01.29
  • Published : 2023.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

References

  1. Fan X, Wang J, Song M, et al. Vitamin D status and risk of all-cause and cause-specific mortality in a large cohort: results from the UK Biobank. J Clin Endocrinol Metab 2020;105:e3606.
  2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685-95.
  3. Lee HY, Lim S, Park S. Role of inflammation in arterial calcification. Korean Circ J 2021;51:114-25.
  4. Chauss D, Freiwald T, McGregor R, et al. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Nat Immunol 2022;23:62-74.
  5. Rathcke CN, Vestergaard H. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. Inflamm Res 2006;55:221-7.
  6. Kastrup J, Johansen JS, Winkel P, et al.; CLARICOR Trial Group. High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease. Eur Heart J 2009;30:1066-72. 
  7. Kocabas R. Effect of vitamin D on YKL-40: rat hypercholesterolemia model. Korean Circ J 2023;53:92-102.
  8. Can U, Uysal S, Ruveyda Ugur A, Toker A, Aslan U, Taha Hidayetoglu B. Can YKL-40 be an inflammatory biomarker in vitamin D deficiency? Int J Vitam Nutr Res 2019;89:309-13.
  9. Omidian M, Mahmoudi M, Javanbakht MH, et al. Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: a randomized, placebocontrolled, double-blind clinical trial. Diabetes Metab Syndr 2019;13:2873-7.
  10. Manson JE, Cook NR, Lee IM, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 2019;380:33-44.