Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Strategy of Patient-Specific Therapeutics in Cardiovascular Disease Through Single-Cell RNA Sequencing

  • Yunseo Jung (Strategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Biomedical Research Institute, Seoul National University Hospital) ;
  • Juyeong Kim (Department of Medicine, Seoul National University College of Medicine, Seoul National University) ;
  • Howon Jang (Department of Medicine, Seoul National University College of Medicine, Seoul National University) ;
  • Gwanhyeon Kim (Department of Medicine, Seoul National University College of Medicine, Seoul National University) ;
  • Yoo-Wook Kwon (Strategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Biomedical Research Institute, Seoul National University Hospital)
  • Received : 2022.11.01
  • Accepted : 2022.11.15
  • Published : 2023.01.01
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Abstract

Recently, single cell RNA sequencing (scRNA-seq) technology has enabled the discovery of novel or rare subtypes of cells and their characteristics. This technique has advanced unprecedented biomedical research by enabling the profiling and analysis of the transcriptomes of single cells at high resolution and throughput. Thus, scRNA-seq has contributed to recent advances in cardiovascular research by the generation of cell atlases of heart and blood vessels and the elucidation of mechanisms involved in cardiovascular development and diseases. This review summarizes the overall workflow of the scRNA-seq technique itself and key findings in the cardiovascular development and diseases based on the previous studies. In particular, we focused on how the single-cell sequencing technology can be utilized in clinical field and precision medicine to treat specific diseases.

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References

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