Acknowledgement
We thank Tomomi Kurata, Misako Tanno, Akiko Hara, and Yoko Mukai for providing technical assistance. We would like to thank Editage (www.editage.com) for English language editing.
References
- Jono K, Takayama T, Kuno M, Higashide E (1986) Effect of alkyl chain length of benzalkonium chloride on the bactericidal activity and binding to organic materials. Chem Pharm Bull (Tokyo) 34:4215-4224. https://doi.org/10.1248/cpb.34.4215
- Hitosugi M, Maruyama K, Takatsu A (1998) A case of fatal benzalkonium chloride poisoning. Int J Legal Med 111:265-266. https://doi.org/10.1007/s004140050166
- Kulbay H, Cevik SE, Vural Z (2014) A case of accidental benzalkonium chloride (10%) ingestion. Turk J Fam Med Prim Care 8:129-132. https://doi.org/10.5455/tjfmpc.165553
- Spiller HA (2014) A case of fatal ingestion of a 10% benzalkonium chloride solution. J Forensic Toxicol Pharmacol. https://doi.org/10.4172/2325-9841.1000113
- Mishima-Kimura S, Yonemitsu K, Ohtsu Y, Sasao A, Tsutsumi H, Furukawa S, Nishitani Y (2018) Liquid chromatography-tandem mass spectrometry detection of benzalkonium chloride (BZK) in a forensic autopsy case with survival for 18 days post BZK ingestion. Leg Med (Tokyo) 32:48-51. https://doi.org/10.1016/j.legalmed.2018.02.006
- Kumar A, Chetiwal R, Rastogi P, Tanwar S, Gupta S, Patnaik R, Vankayalapati M, Gupta S, Arya A (2021) Severe esophagitis and chemical pneumonitis as a consequence of dilute benzalkonium chloride ingestion: a case report. Int J Med Stud 9:231-234. https://doi.org/10.5195/ijms.2021.969
- Handrean IGE, Bagiada IM, Andrika P, Sajinadiyasa IGK (2021) Acute respiratory distress syndrome (ARDS) caused by benzalkonium chloride (BAC) 15% intoxication. Int J Med Rev Case Rep 5:28-32. https://doi.org/10.5455/IJMRCR.ards-Benzalkonium-Chloride
- Miyauchi M, Hayashida M, Yokota H (2014) Benzalkonium chloride intoxication caused by intravenous self-injection. Chudoku Kenkyu 27:327-332. http://jsct-web.umin.jp/
- Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Nef M, Stern EJ, Hudson LD (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353:1685-1693. https://doi.org/10.1056/NEJMoa050333
- Matthay MA, Ware LB, Zimmerman GA (2012) The acute respiratory distress syndrome. J Clin Invest 122:2731-2740. https://doi.org/10.1172/JCI60331
- Umbrello M, Formenti P, Bolgiaghi L, Chiumello D (2016) Current concepts of ARDS: a narrative review. Int J Mol Sci 18:64. https://doi.org/10.3390/ijms18010064
- Thille AW, Esteban A, Fernandez-Segoviano P, Rodriguez JM, Aramburu JA, Vargas-Errazuriz P, Martin-Pellicer A, Lorente JA, Frutos-Vivar F (2013) Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies. Lancet Respir Med 1:395-401. https://doi.org/10.1016/S2213-2600(13)70053-5
- Castro CY (2006) ARDS and diffuse alveolar damage: a pathologist's perspective. Semin Thorac Cardiovasc Surg 18:13-19. https://doi.org/10.1053/j.semtcvs.2006.02.001
- Deutschle T, Porkert U, Reiter R, Keck T, Riechelmann H (2006) In vitro genotoxicity and cytotoxicity of benzalkonium chloride. Toxicol In Vitro 20:1472-1477. https://doi.org/10.1016/j.tiv.2006.07.006
- Pauly A, Meloni M, Brignole-Baudouin F, Warnet JM, Baudouin C (2009) Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride: early detection of toxic damage. Invest Ophthalmol Vis Sci 50:1644-1652. https://doi.org/10.1167/iovs.08-2992
- Kim SH, Kwon D, Lee S, Son SW, Kwon JT, Kim PJ, Lee YH, Jung YS (2020) Concentration- and time-dependent effects of benzalkonium chloride in human lung epithelial cells: necrosis, apoptosis, or epithelial mesenchymal transition. Toxics 8:17. https://doi.org/10.3390/toxics8010017
- Vitoux MA, Kessal K, Melik Parsadaniantz S, Claret M, Guerin C, Baudouin C, Brignole-Baudouin F, Reaux-Le Goazigo A (2020) Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro. Toxicol Lett 319:74-84. https://doi.org/10.1016/j.toxlet.2019.10.014
- Kanno S, Hirano S, Kato H, Fukuta M, Mukai T, Aoki Y (2020) Benzalkonium chloride and cetylpyridinium chloride induce apoptosis in human lung epithelial cells and alter surface activity of pulmonary surfactant monolayers. Chem Biol Interact 317:108962. https://doi.org/10.1016/j.cbi.2020.108962
- Kawasaki M, Kuwano K, Hagimoto N, Matsuba T, Kunitake R, Tanaka T, Maeyama T, Hara N (2000) Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Am J Pathol 157:597-603. https://doi.org/10.1016/S0002-9440(10)64570-1
- Xue Y, Hieda Y, Kimura K, Nishiyama T, Adachi T (2002) Sensitive determination of benzalkonium chloride in blood and tissues using high-performance liquid chromatography with solid-phase extraction. Leg Med (Tokyo) 4:232-238. https://doi.org/10.1016/s1344-6223(02)00036-6
- Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM, Acute Lung Injury in Animals Study Group (2011) An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 44:725-738. https://doi.org/10.1165/rcmb.2009-0210ST
- Sekijima H, Hiramoto K, Kozawa S (2020) A decrease in the tear secretion volume in a mouse model with ulcerative colitis. Cutan Ocul Toxicol 39:363-369. https://doi.org/10.1080/15569527.2020.1825471
- Cosmet Ingredient Rev Expert Panel Staff USA (1989) 2 Final report on the safety assessment of benzalkonium chloride. J Am Coll Toxicol 8:589-625. https://doi.org/10.3109/10915818909010524
- Xue Y, Zhang S, Tang M, Zhang T, Wang Y, Hieda Y, Takeshita H (2012) Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats. J Appl Toxicol 32:480-487. https://doi.org/10.1002/jat.1662
- Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495-516. https://doi.org/10.1080/01926230701320337
- Shi Y (2001) A structural view of mitochondria-mediated apoptosis. Nat Struct Biol 8:394-401. https://doi.org/10.1038/87548
- Goldstein MH, Silva FQ, Blender N, Tran T, Vantipalli S (2022) Ocular benzalkonium chloride exposure: problems and solutions. Eye (Lond) 36:361-368. https://doi.org/10.1038/s41433-021-01668-x
- Cai J, Yang J, Jones DP (1998) Mitochondrial control of apoptosis: the role of cytochrome c. Biochim Biophys Acta 1366:139-149. https://doi.org/10.1016/s0005-2728(98)00109-1
- Kulms D, Schwarz T (2000) Molecular mechanisms of UV-induced apoptosis. Photodermatol Photoimmunol Photomed 16:195-201. https://doi.org/10.1034/j.1600-0781.2000.160501.x
- Perini GF, Ribeiro GN, Pinto Neto JV, Campos LT, Hamerschlak N (2018) BCL-2 as therapeutic target for hematological malignancies. J Hematol Oncol 11:65. https://doi.org/10.1186/s13045-018-0608-2
- Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G (2017) In vitro evaluation of mitochondrial function and estrogen signaling in cell lines exposed to the antiseptic cetylpyridinium chloride. Environ Health Perspect 125:087015. https://doi.org/10.1289/EHP1404
- Debbasch C, Brignole F, Pisella PJ, Warnet JM, Rat P, Baudouin C (2001) Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells. Invest Ophthalmol Vis Sci 42:642-652. https://iovs.arvojournals.org/
- Okamoto A, Tanaka M, Sumi C, Oku K, Kusunoki M, Nishi K, Matsuo Y, Takenaga K, Shingu K, Hirota K (2016) The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. BMC Anesthesiol 16:104. https://doi.org/10.1186/s12871-016-0273-3
- Lee H, Park K (2019) Acute toxicity of benzalkonium chloride in BALB/c mice following intratracheal instillation and oral administration. Environ Anal Health Toxicol 34:e2019009. https://doi.org/10.5620/eaht.e2019009
- De Saint Jean M, Brignole F, Bringuier AF, Bauchet A, Feldmann G, Baudouin C (1999) Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci 40:619-630. https://iovs.arvojournals.org/
- Mannou H, Ikemura M, Nagakawa Y, Nata M, Inoue H (2014) An autopsy case of serotonin toxicity resulting from suicidal administrations of fluvoxamine and lithium. Rom J Leg Med 22:59-62. https://doi.org/10.4323/rjlm.2014.59
- Oshima T, Sasao A, Sekijima H, Kotani H (2023) A case of carbon monoxide poisoning before a vehicle fire: availability of volatile hydrocarbons analysis. Leg Med (Tokyo) 60:102174. https://doi.org/10.1016/j.legalmed.2022.102174