The Korean Journal of Pain

  • 제36권3호
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  • Pages.335-346
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  • 2023
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats

  • QingLing Zhai (Department of Neurology, First Affiliated Hospital of Harbin Medical University) ;
  • KaiXin Wang (Department of Neurology, The Third Hospital of Jinan Shandong) ;
  • Defu Zhang (Department of Neurology, Shengli Oilfield Central Hospital) ;
  • Jinbo Chen (Department of Neurology, Binzhou Medical University Hospital) ;
  • XiaoMeng Dong (Department of Neurology, Binzhou Medical University Hospital) ;
  • Yonghui Pan (Department of Neurology, First Affiliated Hospital of Harbin Medical University)
  • 투고 : 2023.02.09
  • 심사 : 2023.06.07
  • 발행 : 2023.07.01
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초록

Background: Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study was to investigate whether perampanel could exert an antimigraine effect. Methods: Nitroglycerin (NTG) was used to induce a migraine model in rats, and the model animals were pretreatment with 50 ㎍/kg and 100 ㎍/kg perampanel. The expression of pituitary adenylate-cyclase-activating polypeptide (PACAP) was quantified by western blot and quantitative real-time PCR in the trigeminal ganglion, and rat-specific enzyme-linked immunosorbent assay in serum. Western blot was also conducted to explore the effects of perampanel treatment on the phospholipase C (PLC)/protein kinase C (PKC) and protein kinase A (PKA)/cAMP-responsive-element-binding protein (CREB) signaling pathways. Moreover, the cAMP/PKA/CREB-dependent mechanism was evaluated via in vitro stimulation of hippocampal neurons. The cells were treated with perampanel, antagonists and agonists for 24 hours and cell lysates were prepared for western blot analysis. Results: Perampanel treatment notably increased the mechanical withdrawal threshold and decreased head grooming and light-aversive behaviors in NTG-treated rats. It also decreased PACAP expression and affected cAMP/PKA/CREB signaling pathway. However, PLC/PKC signaling pathway may not be involved in this treatment. In in vitro studies, perampanel notably decreased PACAP expression by inhibiting cAMP/PKA/CREB signaling pathway. Conclusions: This study shows that perampanel inhibits the migraine-like pain response and that this beneficial effect might be attributable to regulation of the cAMP/PKA/CREB signaling pathway.

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과제정보

We would like to thank Dr. Bin Liu and Dr. Zunling Li for their valuable suggestions on our manuscript.

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