DOI QR코드

DOI QR Code

Fission-Fueled Nucleoid Dispersion, a Novel Mitochondrial Metabolic Activation Mechanism

  • Jeongah Kim (Department of Anatomy, College of Medicine, Korea University)
  • 투고 : 2023.03.14
  • 심사 : 2023.03.23
  • 발행 : 2023.05.31

초록

키워드

과제정보

This work was supported by grants from the National Research Foundation of Korea (NRF-2021R1A2C1010677).

참고문헌

  1. Agaronyan, K., Morozov, Y.I., Anikin, M., and Temiakov, D. (2015). Replication-transcription switch inhuman mitochondria. Science 347, 548-551. https://doi.org/10.1126/science.aaa0986
  2. Arguello, T., Peralta, S., Antonicka, H., Gaidosh, G., Diaz, F., Tu, Y.T., Garcia, S., Shiekhattar, R., Barrientos, A., and Moraes, C.T. (2021). ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly. Cell Rep. 37, 110139.
  3. Ban-Ishihara, R., Ishihara, T., Sasaki, N., Mihara, K., and Ishihara, N. (2013). Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c. Proc. Natl. Acad. Sci. U. S. A. 110, 11863-11868. https://doi.org/10.1073/pnas.1301951110
  4. Cho, B., Cho, H.M., Jo, Y., Kim, H.D., Song, M., Moon, C., Kim, H., Kim, K., Sesaki, H., Rhyu, I.J., et al. (2017). Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat. Commun. 8, 15754.
  5. Gureev, A.P., Shaforostova, E.A., and Popov, V.N. (2019). Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1alpha signaling pathways. Front. Genet. 10, 435.
  6. Ishihara, T., Ban-Ishihara, R., Ota, A., and Ishihara, N. (2022). Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation. Proc. Natl. Acad. Sci. U. S. A. 119, e2210730119.
  7. Lewis, S.C., Uchiyama, L.F., and Nunnari, J. (2016). ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells. Science 353, aaf5549.
  8. Nicholls, T.J. and Gustafsson, C.M. (2018). Separating and segregating the human mitochondrial genome. Trends Biochem. Sci. 43, 869-881. https://doi.org/10.1016/j.tibs.2018.08.007
  9. Peralta, S., Goffart, S., Williams, S.L., Diaz, F., Garcia, S., Nissanka, N., Area-Gomez, E., Pohjoismaki, J., and Moraes, C.T. (2018). ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels. J. Cell Sci. 131, jcs217075.