Molecules and Cells

  • 제46권5호
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  • Pages.259-267
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  • 2023
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation

  • Min-Ji Kim (Department of Internal Medicine, School of Medicine, Kyungpook National University Chilgok Hospital) ;
  • Hoyul Lee (Research Institute of Aging and Metabolism, Kyungpook National University) ;
  • Dipanjan Chanda (Research Institute of Aging and Metabolism, Kyungpook National University) ;
  • Themis Thoudam (Research Institute of Aging and Metabolism, Kyungpook National University) ;
  • Hyeon-Ji Kang (Research Institute of Aging and Metabolism, Kyungpook National University) ;
  • Robert A. Harris (Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center) ;
  • In-Kyu Lee (Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University)
  • 투고 : 2022.08.18
  • 심사 : 2022.11.18
  • 발행 : 2023.05.31
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초록

Pyruvate metabolism, a key pathway in glycolysis and oxidative phosphorylation, is crucial for energy homeostasis and mitochondrial quality control (MQC), including fusion/fission dynamics and mitophagy. Alterations in pyruvate flux and MQC are associated with reactive oxygen species accumulation and Ca2+ flux into the mitochondria, which can induce mitochondrial ultrastructural changes, mitochondrial dysfunction and metabolic dysregulation. Perturbations in MQC are emerging as a central mechanism for the pathogenesis of various metabolic diseases, such as neurodegenerative diseases, diabetes and insulin resistance-related diseases. Mitochondrial Ca2+ regulates the pyruvate dehydrogenase complex (PDC), which is central to pyruvate metabolism, by promoting its dephosphorylation. Increase of pyruvate dehydrogenase kinase (PDK) is associated with perturbation of mitochondria-associated membranes (MAMs) function and Ca2+ flux. Pyruvate metabolism also plays an important role in immune cell activation and function, dysregulation of which also leads to insulin resistance and inflammatory disease. Pyruvate metabolism affects macrophage polarization, mitochondrial dynamics and MAM formation, which are critical in determining macrophage function and immune response. MAMs and MQCs have also been intensively studied in macrophage and T cell immunity. Metabolic reprogramming connected with pyruvate metabolism, mitochondrial dynamics and MAM formation are important to macrophages polarization (M1/M2) and function. T cell differentiation is also directly linked to pyruvate metabolism, with inhibition of pyruvate oxidation by PDKs promoting proinflammatory T cell polarization. This article provides a brief review on the emerging role of pyruvate metabolism in MQC and MAM function, and how dysfunction in these processes leads to metabolic and inflammatory diseases.

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과제정보

M.-J.K. is supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2022R1C1C101089811). H.L. is supported by the Basic Science Research Program, through the NRF of Korea government (MSIT) (2020R1C1C1009322). H.-J.K. is supported by Basic Science Research Program through the NRF of Korea funded by the Ministry of Education (2019R1I1A1A01062968). I.-K.L. is supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant No. HR22C1832).

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