Clinical Nutrition Research

  • 제12권4호
  • /
  • Pages.269-282
  • /
  • 2023
  • /
  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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The Effect of Vit-D Supplementation on the Side Effect of BioNTech, Pfizer Vaccination and Immunoglobulin G Response Against SARS-CoV-2 in the Individuals Tested Positive for COVID-19: A Randomized Control Trial

  • Hawal Lateef Fateh (Nursing Department, Kalar Technical College, Garmian Polytechnic University) ;
  • Goran Kareem (Medical Laboratory Technology, Kalar Technical College, Garmian Polytechnic University) ;
  • Shahab Rezaeian (Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences) ;
  • Jalal Moludi (School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences) ;
  • Negin Kamari (School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences)
  • 투고 : 2023.05.27
  • 심사 : 2023.08.25
  • 발행 : 2023.10.30
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초록

Vitamin D participates in the biological function of the innate and adaptive immune system and inflammation. We aim to specify the effectiveness of the vitamin D supplementation on the side effects BioNTech, Pfizer vaccination, and immunoglobulin G response against severe acute respiratory syndrome coronavirus 2 in subjects tested positive for coronavirus disease 2019 (COVID-19). In this multi-center randomized clinical trial, 498 people tested positive for COVID-19 were divided into 2 groups, receiving vitamin D capsules or a placebo (1 capsule daily, each containing 600 IU of vitamin D) over 14-16 weeks. Anthropometric indices and biochemical parameters were measured before and after the second dose of vaccination. Fourteen to 16 weeks after supplementation, the intervention group had an immunoglobulin G (IgG) increase of 10.89 ± 1.2 g/L, while the control group had 8.89 ± 1.3 g/L, and the difference was significant between both groups (p = 0.001). After the second dose of vaccination, the supplement group significantly increased their 25-hydroxy vitamin D from initially 28.73 ± 15.6 ng/mL and increased to 46.48 ± 27.2 ng/mL, and the difference between them was significant. Those with a higher body mass index (BMI) had the most of symptoms, and the difference of side effects according to BMI level was significantly different. In 8 weeks after supplementation obese participants had the lowest IgG levels than overweight or normal subjects. The proportion of all types of side effects on the second dose was significantly diminished compared with the first dose in the intervention group. Supplementation of 600 IU of vitamin D3 can reduce post-vaccination side effects and increase IgG levels in participants who received BioNTech, Pfizer vaccine.

키워드

과제정보

We would like to thanks each participant and deputy of Garmian Polytechnic University.

참고문헌

  1. World Health Organization. Coronavirus disease (COVID-19) situation report-127. Geneva: World Health Organization; 2020.
  2. World Health Organization. Draft landscape and tracker of COVID-19 candidate vaccines. Geneva: World Health Organization; 2020.
  3. U.S. Food and Drug Administration. Pfizer-BioNTech COVID-19 vaccine. Silver Spring (MD): U.S. Food and Drug Administration; 2021.
  4. Ng WH, Tipih T, Makoah NA, Vermeulen JG, Goedhals D, Sempa JB, Burt FJ, Taylor A, Mahalingam S. Comorbidities in SARS-CoV-2 patients: a systematic review and meta-analysis. MBio 2021;12:e03647-20. 
  5. Di Resta C, Ferrari D, Vigano M, Moro M, Sabetta E, Minerva M, Ambrosio A, Locatelli M, Tomaiuolo R. The gender impact assessment among healthcare workers in the SARS-CoV-2 vaccination-an analysis of serological response and side effects. Vaccines (Basel) 2021;9:522. 
  6. Fateh HL, Kamari NM, Ali A, Moludi J, Rezayaeian S. Association between diet quality and BMI with side effects of Pfizer-BioNTech COVID-19 vaccine and SARS-CoV-2 immunoglobulin G titers. Nutr Food Sci 2023;53:738-51. 
  7. Pellini R, Venuti A, Pimpinelli F, Abril E, Blandino G, Campo F, Conti L, De Virgilio A, De Marco F, Di Domenico EG, Di Bella O, Di Martino S, Ensoli F, Giannarelli D, Mandoj C, Manciocco V, Marchesi P, Mazzola F, Moretto S, Petruzzi G, Petrone F, Pichi B, Pontone M, Zocchi J, Vidiri A, Vujovic B, Piaggio G, Morrone A, Ciliberto G. Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine. EClinicalMedicine 2021;36:100928. 
  8. Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients 2020;12:236. 
  9. Jovic TH, Ali SR, Ibrahim N, Jessop ZM, Tarassoli SP, Dobbs TD, Holford P, Thornton CA, Whitaker IS. Could vitamins help in the fight against COVID-19? Nutrients 2020;12:2550. 
  10. Name JJ, Souza ACR, Vasconcelos AR, Prado PS, Pereira CPM. Zinc, vitamin D and vitamin C: perspectives for COVID-19 with a focus on physical tissue barrier integrity. Front Nutr 2020;7:606398. 
  11. Gray TK, Lowe W, Lester GE. Vitamin D and pregnancy: the maternal-fetal metabolism of vitamin D. Endocr Rev 1981;2:264-74. 
  12. Zisi D, Challa A, Makis A. The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood. Hormones (Athens) 2019;18:353-63. 
  13. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005;97:93-101. 
  14. Christianto V, Smarandache F. A review of major role of vitamin D3 in human immune system and its possible use for novel corona virus treatment. EC Microbiol 2020;16.6:10-6.
  15. Iguacel I, Maldonado AL, Ruiz-Cabello AL, Casaus M, Moreno LA, Martinez-Jarreta B. Association between COVID-19 vaccine side effects and body mass index in Spain. Vaccines (Basel) 2021;9:1321. 
  16. Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE. Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 2003;6:407-13. 
  17. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ; American College of Cardiology/American Heart Association Task Force on Practice GuidelinesObesity Society. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol 2014;63:2985-3023. 
  18. Lau FH, Majumder R, Torabi R, Saeg F, Hoffman R, Cirillo JD, Greiffenstein P. Vitamin D insufficiency is prevalent in severe COVID-19. medRxiv. Forthcoming 2020. 
  19. Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol 2011;50:194-200. 
  20. Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf ) 2012;76:315-25.
  21. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients 2015;7:4240-70. 
  22. Wei R, Christakos S. Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D. Nutrients 2015;7:8251-60. 
  23. Lang PO, Aspinall R. Vitamin D status and the host resistance to infections: what it is currently (not) understood. Clin Ther 2017;39:930-45. 
  24. Gruber-Bzura BM. Vitamin D and influenza-prevention or therapy? Int J Mol Sci 2018;19:2419. 
  25. Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. Vitamin D-directed rheostatic regulation of monocyte antibacterial responses. J Immunol 2009;182:4289-95. 
  26. Laaksi I. Vitamin D and respiratory infection in adults. Proc Nutr Soc 2012;71:90-7. 
  27. Herr C, Shaykhiev R, Bals R. The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther 2007;7:1449-61. 
  28. Agier J, Efenberger M, Brzezinska-Blaszczyk E. Cathelicidin impact on inflammatory cells. Centr Eur J Immunol 2015;40:225-35. 
  29. Zhao Y, Ran Z, Jiang Q, Hu N, Yu B, Zhu L, Shen L, Zhang S, Chen L, Chen H, Jiang J, Chen D. Vitamin D alleviates rotavirus infection through a microrna-155-5p mediated regulation of the TBK1/IRF3 signaling pathway in vivo and in vitro. Int J Mol Sci 2019;20:3562. 
  30. Martinez-Moreno J, Hernandez JC, Urcuqui-Inchima S. Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells. Mol Cell Biochem 2020;464:169-80. 
  31. Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 2003;23:117-45. 
  32. Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P. Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporos Int 2008;19:663-71. 
  33. Puspitaningtyas H, Sulistyoningrum DC, Witaningrum R, Widodo I, Hardianti MS, Taroeno-Hariadi KW, Kurnianda J, Purwanto I, Hutajulu SH. Vitamin D status in breast cancer cases following chemotherapy: a pre and post observational study in a tertiary hospital in Yogyakarta, Indonesia. PLoS One 2022;17:e0270507. 
  34. Charoenngam N, Holick MF. Immunologic effects of vitamin D on human health and disease. Nutrients 2020;12:2097. 
  35. Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C, Coussens AK, Richter AG, McKnight A, Martineau AR. Vitamin D supplementation does not influence SARS-CoV-2 vaccine efficacy or immunogenicity: sub-studies nested within the CORONAVIT randomised controlled trial. Nutrients 2022;14:3821. 
  36. Chillon TS, Demircan K, Heller RA, Hirschbil-Bremer IM, Diegmann J, Bachmann M, Moghaddam A, Schomburg L. Relationship between vitamin D status and antibody response to COVID-19 mRNA vaccination in healthy adults. Biomedicines 2021;9:1714. 
  37. Speakman LL, Michienzi SM, Badowski ME. Vitamins, supplements and COVID-19: a review of currently available evidence. Drugs Context 2021;10:2021-6-2. 
  38. Menni C, Klaser K, May A, Polidori L, Capdevila J, Louca P, Sudre CH, Nguyen LH, Drew DA, Merino J, Hu C, Selvachandran S, Antonelli M, Murray B, Canas LS, Molteni E, Graham MS, Modat M, Joshi AD, Mangino M, Hammers A, Goodman AL, Chan AT, Wolf J, Steves CJ, Valdes AM, Ourselin S, Spector TD. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infect Dis 2021;21:939-49. 
  39. Akbar MR, Wibowo A, Pranata R, Setiabudiawan B. Low serum 25-hydroxyvitamin D (vitamin D) level is associated with susceptibility to COVID-19, severity, and mortality: a systematic review and meta-analysis. Front Nutr 2021;8:660420. 
  40. Petrelli F, Luciani A, Perego G, Dognini G, Colombelli PL, Ghidini A. Therapeutic and prognostic role of vitamin D for COVID-19 infection: a systematic review and meta-analysis of 43 observational studies. J Steroid Biochem Mol Biol 2021;211:105883. 
  41. Brenner H. Vitamin D supplementation to prevent COVID-19 infections and deaths-accumulating evidence from epidemiological and intervention studies calls for immediate action. Nutrients 2021;13:411. 
  42. Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, Puri GD, Malhotra P. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgrad Med J 2022;98:87-90. 
  43. Kumar P, Kumar M, Bedi O, Gupta M, Kumar S, Jaiswal G, Rahi V, Yedke NG, Bijalwan A, Sharma S, Jamwal S. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacology 2021;29:1001-16. 
  44. Thirumdas R, Kothakota A, Pandiselvam R, Bahrami A, Barba FJ. Role of food nutrients and supplementation in fighting against viral infections and boosting immunity: a review. Trends Food Sci Technol 2021;110:66-77. 
  45. Park CS, Shastri N. The role of T cells in obesity-associated inflammation and metabolic disease. Immune Netw 2022;22:e13. 
  46. Dearman RJ, Cumberbatch M, Maxwell G, Basketter DA, Kimber I. Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells. Immunology 2009;126:475-84. 
  47. Zhou Q, Leeman SE, Amar S. Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A 2009;106:10740-5. 
  48. Liu F, Guo Z, Dong C. Influences of obesity on the immunogenicity of Hepatitis B vaccine. Hum Vaccin Immunother 2017;13:1014-7. 
  49. Wypych TP, Marsland BJ, Ubags ND. The impact of diet on immunity and respiratory diseases. Ann Am Thorac Soc 2017;14:S339-47. 
  50. McNeil MM, Chiang IS, Wheeling JT, Zhang Y. Short-term reactogenicity and gender effect of anthrax vaccine: analysis of a 1967-1972 study and review of the 1955-2005 medical literature. Pharmacoepidemiol Drug Saf 2007;16:259-74. 
  51. Pondo T, Rose CE Jr, Martin SW, Keitel WA, Keyserling HL, Babcock J, Parker S, Jacobson RM, Poland GA, McNeil MM. Evaluation of sex, race, body mass index and pre-vaccination serum progesterone levels and post-vaccination serum anti-anthrax protective immunoglobulin G on injection site adverse events following anthrax vaccine adsorbed (AVA) in the CDC AVA human clinical trial. Vaccine 2014;32:3548-54. 
  52. Petousis-Harris H, Jackson C, Stewart J, Coster G, Turner N, Goodyear-Smith F, Lennon D. Factors associated with reported pain on injection and reactogenicity to an OMV meningococcal B vaccine in children and adolescents. Hum Vaccin Immunother 2015;11:1875-80. 
  53. Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci 2017;13:851-63.