DOI QR코드

DOI QR Code

The Impact of Surgical Timing of Hip Fracture on Mortality: Do the Cause and Duration of Delay Matter?

  • Jaiben George (Department of Orthopedic Surgery, All India Institute of Medical Sciences (AIIMS)) ;
  • Vijay Sharma (Department of Orthopedic Surgery, All India Institute of Medical Sciences (AIIMS)) ;
  • Kamran Farooque (Department of Orthopedic Surgery, All India Institute of Medical Sciences (AIIMS)) ;
  • Samarth Mittal (Department of Orthopedic Surgery, All India Institute of Medical Sciences (AIIMS)) ;
  • Vivek Trikha (Department of Orthopedic Surgery, All India Institute of Medical Sciences (AIIMS)) ;
  • Rajesh Malhotra (Department of Orthopedic Surgery, All India Institute of Medical Sciences (AIIMS))
  • 투고 : 2022.10.12
  • 심사 : 2023.06.18
  • 발행 : 2023.09.30

초록

Purpose: Delay in performance of hip fracture surgery can be caused by medical and/or administrative reasons. Although early surgery is recommended, it is unclear what constitutes a delayed surgery and whether the impact of delayed surgery can differ depending on the reason for the delay. Materials and Methods: A total of 269 consecutive hip fracture patients over 50 years of age who underwent surgery were prospectively enrolled. They were divided into two groups: early and delayed (time from reaching the hospital to surgery less than or more than 48 hours). Patients were also categorized as fit or unfit based on anesthetic fitness. One-year mortality was recorded, and regression analyses were performed to assess the impact of delay on mortality. Results: A total of 153 patients (56.9%) had delayed surgery with a mean time to surgery of 87±70 hours. A total of 115 patients (42.8%) were considered medically fit to undergo surgery. No difference in one-year mortality was observed between patients with early surgery and those with delayed surgery (P=0.854). However, when assessment of the time to surgery was performed in a continuous manner, mortality increased with prolonged time to surgery, particularly in unfit patients, and higher mortality was observed when the delay exceeded six days (fit: P=0.117; unfit: P=0.035). Conclusion: The effect of delay on mortality was predominantly observed in patients who were not considered medically fit, suggesting that surgical delays might have a greater impact on patients with medical reasons for delay.

키워드

참고문헌

  1. Roberts SE, Goldacre MJ. Time trends and demography of mortality after fractured neck of femur in an English population, 1968-98: database study. BMJ. 2003;327:771-5. https://doi.org/10.1136/bmj.327.7418.771 
  2. Panula J, Pihlajamaki H, Mattila VM, et al. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011;12:105. https://doi.org/10.1186/1471-2474-12-105 
  3. Groff H, Kheir MM, George J, Azboy I, Higuera CA, Parvizi J. Causes of in-hospital mortality after hip fractures in the elderly. Hip Int. 2020;30:204-9. https://doi.org/10.1177/1120700019835160 
  4. Carpintero P, Caeiro JR, Carpintero R, Morales A, Silva S, Mesa M. Complications of hip fractures: a review. World J Orthop. 2014;5:402-11. https://doi.org/10.5312/wjo.v5.i4.402 
  5. Handoll HH, Farrar MJ, McBirnie J, Tytherleigh-Strong G, Milne AA, Gillespie WJ. Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following surgery for hip fractures. Cochrane Database Syst Rev. 2002;(4):CD000305. https://doi.org/10.1002/14651858.CD000305 
  6. Orosz GM, Magaziner J, Hannan EL, et al. Association of timing of surgery for hip fracture and patient outcomes. JAMA. 2004;291:1738-43. https://doi.org/10.1001/jama.291.14.1738 
  7. Nyholm AM, Gromov K, Palm H, Brix M, Kallemose T, Troelsen A. Time to surgery is associated with thirty-day and ninety-day mortality after proximal femoral fracture: a retrospective observational study on prospectively collected data from the Danish Fracture Database collaborators. J Bone Joint Surg Am. 2015;97:1333-9. https://doi.org/10.2106/JBJS.O.00029 
  8. Khan SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ. Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury. 2009;40:692-7. https://doi.org/10.1016/j.injury.2009.01.010 
  9. Maheshwari K, Planchard J, You J, et al. Early surgery confers 1-year mortality benefit in hip-fracture patients. J Orthop Trauma. 2018;32:105-10. https://doi.org/10.1097/BOT.0000000000001043 
  10. Simunovic N, Devereaux PJ, Bhandari M. Surgery for hip fractures: does surgical delay affect outcomes? Indian J Orthop. 2011;45:27-32. https://doi.org/10.4103/0019-5413.73660 
  11. Voeten SC, Krijnen P, Voeten DM, Hegeman JH, Wouters MWJM, Schipper IB. Quality indicators for hip fracture care, a systematic review. Osteoporos Int. 2018;29:1963-85. https://doi.org/10.1007/s00198-018-4558-x 
  12. Bhandari M, Sprague S, Schemitsch EH; International Hip Fracture Research Collaborative. Resolving controversies in hip fracture care: the need for large collaborative trials in hip fractures. J Orthop Trauma. 2009;23:479-84. https://doi.org/10.1097/BOT.0b013e3181a772e3 
  13. HIP ATTACK Investigators. Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. Lancet. 2020;395:698-708. https://doi.org/10.1016/S0140-6736(20)30058-1 Erratum in: Lancet 2021;398:1964. Erratum in: Lancet 2023;401:1078. 
  14. American Academy of Orthopaedic Surgeons (AAOS). Management of hip fractures in the elderly: evidence-based clinical practice guideline [Internet]. Rosemont: AAOS; 2014 Sep 5 [cited 2022 Mar 3]. Available from: https://www.aaos.org/globalassets/quality-and-practice-resources/hip-fractures-in-the-elderly/management_of_hip_fractures_in_the_elderly-7-24-19.pdf 
  15. Rath S, Yadav L, Tewari A, et al. Management of older adults with hip fractures in India: a mixed methods study of current practice, barriers and facilitators, with recommendations to improve care pathways. Arch Osteoporos. 2017;12:55. https://doi.org/10.1007/s11657-017-0344-1 
  16. Moran CG, Wenn RT, Sikand M, Taylor AM. Early mortality after hip fracture: is delay before surgery important? J Bone Joint Surg Am. 2005;87:483-9. https://doi.org/10.2106/JBJS.D.01796 
  17. George J, Sharma V, Farooque K, Mittal S, Trikha V, Malhotra R. Factors associated with delayed surgery in elderly hip fractures in India. Arch Osteoporos. 2021;16:7. https://doi.org/10.1007/s11657-020-00858-6 
  18. Meira-Machado L, Cadarso-Suarez C, Gude F, Araujo A. smoothHR: an R package for pointwise nonparametric estimation of hazard ratio curves of continuous predictors. Comput Math Methods Med. 2013;2013:745742. https://doi.org/10.1155/2013/745742 
  19. Ftouh S, Morga A, Swift C; Guideline Development Group. Management of hip fracture in adults: summary of NICE guidance. BMJ. 2011;342:d3304. https://doi.org/10.1136/bmj.d3304 
  20. Dash SK, Panigrahi R, Palo N, Priyadarshi A, Biswal M. Fragility hip fractures in elderly patients in Bhubaneswar, India (2012-2014): a prospective multicenter study of 1031 elderly patients. Geriatr Orthop Surg Rehabil. 2015;6:11-5. https://doi.org/10.1177/2151458514555570 
  21. Dhanwal DK, Siwach R, Dixit V, Mithal A, Jameson K, Cooper C. Incidence of hip fracture in Rohtak district, North India. Arch Osteoporos. 2013;8:135. https://doi.org/10.1007/s11657-013-0135-2 
  22. Skirbekk V, James KS. Abuse against elderly in India--the role of education. BMC Public Health. 2014;14:336. https://doi.org/10.1186/1471-2458-14-336 
  23. Schoeneberg C, Aigner R, Pass B, et al. Effect of time-to-surgery on in-house mortality during orthogeriatric treatment following hip fracture: a retrospective analysis of prospectively collected data from 16,236 patients of the AltersTraumaRegister DGU. Injury. 2021;52:554-61. https://doi.org/10.1016/j.injury.2020.09.007 
  24. Smektala R, Endres HG, Dasch B, et al. The effect of time-to-surgery on outcome in elderly patients with proximal femoral fractures. BMC Musculoskelet Disord. 2008;9:171. https://doi.org/10.1186/1471-2474-9-171 
  25. Novack V, Jotkowitz A, Etzion O, Porath A. Does delay in surgery after hip fracture lead to worse outcomes? A multicenter survey. Int J Qual Health Care. 2007;19:170-6. https://doi.org/10.1093/intqhc/mzm003 
  26. Siegmeth AW, Gurusamy K, Parker MJ. Delay to surgery prolongs hospital stay in patients with fractures of the proximal femur. J Bone Joint Surg Br. 2005;87:1123-6. https://doi.org/10.1302/0301-620X.87B8.16357 
  27. Beloosesky Y, Hendel D, Weiss A, et al. Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci. 2007;62:420-6. https://doi.org/10.1093/gerona/62.4.420 
  28. Brauer C, Morrison RS, Silberzweig SB, Siu AL. The cause of delirium in patients with hip fracture. Arch Intern Med. 2000;160:1856-60. https://doi.org/10.1001/archinte.160.12.1856 
  29. George J, Sharma V, Farooque K, Mittal S, Trikha V, Malhotra R. Injury mechanisms of hip fractures in India. Hip Pelvis. 2021;33:62-70. https://doi.org/10.5371/hp.2021.33.2.62