Acknowledgement
We thank all Cell2in members for their assistance with this study. This work was supported by a Jeju National University research grant in 2021.
References
- Lu SC. Glutathione synthesis. Biochim Biophys Acta 2013;1830:3143-3153 https://doi.org/10.1016/j.bbagen.2012.09.008
- Winterbourn CC, Hampton MB. Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 2008;45:549-561 https://doi.org/10.1016/j.freeradbiomed.2008.05.004
- Jeong EM, Yoon JH, Lim J, Shin JW, Cho AY, Heo J, Lee KB, Lee JH, Lee WJ, Kim HJ, Son YH, Lee SJ, Cho SY, Shin DM, Choi K, Kim IG. Real-time monitoring of glutathione in living cells reveals that high glutathione levels are required to maintain stem cell function. Stem Cell Reports 2018;10:600-614 https://doi.org/10.1016/j.stemcr.2017.12.007
- Lim J, Heo J, Ju H, Shin JW, Kim Y, Lee S, Yu HY, Ryu CM, Yun H, Song S, Hong KS, Chung HM, Kim HR, Roe JS, Choi K, Kim IG, Jeong EM, Shin DM. Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway. Sci Adv 2020;6:eaba1334
- Lim J, Heo J, Yu HY, Yun H, Lee S, Ju H, Nam YJ, Jeong SM, Lee J, Cho YS, Choo MS, Jeong EM, Ryu CM, Shin DM. Small-sized mesenchymal stem cells with high glutathione dynamics show improved therapeutic potency in graftversus-host disease. Clin Transl Med 2021;11:e476
- Ribas V, Garcia-Ruiz C, Fernandez-Checa JC. Glutathione and mitochondria. Front Pharmacol 2014;5:151
- Mari M, Morales A, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta 2013;1830:3317-3328 https://doi.org/10.1016/j.bbagen.2012.10.018
- Cho AY, Choi K. A coumarin-based fluorescence sensor for the reversible detection of thiols. Chem Lett 2012;41:1611-1612 https://doi.org/10.1246/cl.2012.1611
- Jeong EM, Shin JW, Lim J, Kim JH, Kang H, Yin Y, Kim HM, Kim Y, Kim SG, Kang HS, Shin DM, Choi K, Kim IG. Monitoring glutathione dynamics and heterogeneity in living stem cells. Int J Stem Cells 2019;12:367-379 https://doi.org/10.15283/ijsc18151
- Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. Biochem Biophys Res Commun 2005;326:799-804 https://doi.org/10.1016/j.bbrc.2004.11.105