International Journal of Stem Cells

Korean Society for Stem Cell Research (한국줄기세포학회)
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Applications of Bioinspired Platforms for Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells

  • Ok-Hyeon Kim (Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University) ;
  • Tae Jin Jeon (Department of Global Innovative Drugs, Graduate School of Chung-Ang University) ;
  • Young In So (Department of Global Innovative Drugs, Graduate School of Chung-Ang University) ;
  • Yong Kyoo Shin (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Hyun Jung Lee (Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University)
  • Received : 2022.12.30
  • Accepted : 2023.03.28
  • Published : 2023.08.30
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Abstract

Mesenchymal stromal cells (MSCs) have attracted scientific and medical interest due to their self-renewing properties, pluripotency, and paracrine function. However, one of the main limitations to the clinical application of MSCs is their loss of efficacy after transplantation in vivo. Various bioengineering technologies to provide stem cell niche-like conditions have the potential to overcome this limitation. Here, focusing on the stem cell niche microenvironment, studies to maximize the immunomodulatory potential of MSCs by controlling biomechanical stimuli, including shear stress, hydrostatic pressure, stretch, and biophysical cues, such as extracellular matrix mimetic substrates, are discussed. The application of biomechanical forces or biophysical cues to the stem cell microenvironment will be beneficial for enhancing the immunomodulatory function of MSCs during cultivation and overcoming the current limitations of MSC therapy.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF), funded by the Korean government [grant number 2020R1A2C2011617]; and by the Chung-Ang University Scholarship Grant in 2022.

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