과제정보
The work was conducted with the SKKU cooperative fund (S-2022-2128-000).
참고문헌
- Kim Y, Jeong J, Choi D. Small-molecule-mediated reprogramming: a silver lining for regenerative medicine. Exp Mol Med 2020;52:213-226 https://doi.org/10.1038/s12276-020-0383-3
- De D, Halder D, Shin I, Kim KK. Small molecule-induced cellular conversion. Chem Soc Rev 2017;46:6241-6254 https://doi.org/10.1039/C7CS00330G
- Aron Badin R, Bugi A, Williams S, Vadori M, Michael M, Jan C, Nassi A, Lecourtois S, Blancher A, Cozzi E, Hantraye P, Perrier AL. MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates. Nat Commun 2019;10:4357
- Medvedev SP, Shevchenko AI, Zakian SM. Induced pluripotent stem cells: problems and advantages when applying them in regenerative medicine. Acta Naturae 2010;2:18-28 https://doi.org/10.32607/20758251-2010-2-2-18-27
- Xie X, Fu Y, Liu J. Chemical reprogramming and transdifferentiation. Curr Opin Genet Dev 2017;46:104-113 https://doi.org/10.1016/j.gde.2017.07.003
- Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Chen L, Jin P, Wu GY, Chen G. Small molecules efficiently reprogram human astroglial cells into functional neurons. Cell Stem Cell 2015;17:735-747 https://doi.org/10.1016/j.stem.2015.09.012
- Yang Y, Chen R, Wu X, Zhao Y, Fan Y, Xiao Z, Han J, Sun L, Wang X, Dai J. Rapid and efficient conversion of human fibroblasts into functional neurons by small molecules. Stem Cell Reports 2019;13:862-876 https://doi.org/10.1016/j.stemcr.2019.09.007
- Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hagg S, Hirano M, Picard M. Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. Epigenetics 2019;14:961-976 https://doi.org/10.1080/15592294.2019.1626651
- Zwaka TP. Stem cells: troublesome memories. Nature 2010;467:280-281 https://doi.org/10.1038/467280a
- Biddy BA, Kong W, Kamimoto K, Guo C, Waye SE, Sun T, Morris SA. Single-cell mapping of lineage and identity in direct reprogramming. Nature 2018;564:219-224 https://doi.org/10.1038/s41586-018-0744-4
- Papp B, Plath K. Epigenetics of reprogramming to induced pluripotency. Cell 2013;152:1324-1343 https://doi.org/10.1016/j.cell.2013.02.043
- Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003;33 Suppl:245-254 https://doi.org/10.1038/ng1089
- He S, Dong G, Li Y, Wu S, Wang W, Sheng C. Potent dual BET/HDAC inhibitors for efficient treatment of pancreatic cancer. Angew Chem Int Ed Engl 2020;59:3028-3032 https://doi.org/10.1002/anie.201915896
- Ren Q, Gao W. Current status in the discovery of dual BET/HDAC inhibitors. Bioorg Med Chem Lett 2021;38:127829
- Gao L, Guan W, Wang M, Wang H, Yu J, Liu Q, Qiu B, Yu Y, Ping Y, Bian X, Shen L, Pei G. Direct generation of human neuronal cells from adult astrocytes by small molecules. Stem Cell Reports 2017;8:538-547 https://doi.org/10.1016/j.stemcr.2017.01.014
- Richner M, Victor MB, Liu Y, Abernathy D, Yoo AS. MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons. Nat Protoc 2015;10:1543-1555 https://doi.org/10.1038/nprot.2015.102
- Yang J, Cao H, Guo S, Zhu H, Tao H, Zhang L, Chen Z, Sun T, Chi S, Hu Q. Small molecular compounds efficiently convert human fibroblasts directly into neurons. Mol Med Rep 2020;22:4763-4771 https://doi.org/10.3892/mmr.2020.11559
- Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y, Zhao J, Pei G. Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules. Cell Stem Cell 2015;17:204-212 https://doi.org/10.1016/j.stem.2015.07.006
- Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z, Zhao Y, Deng H. Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell 2015;17:195-203 https://doi.org/10.1016/j.stem.2015.06.003
- Qin H, Zhao AD, Sun ML, Ma K, Fu XB. Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors. Mil Med Res 2020;7:52
- Wan XY, Xu LY, Li B, Sun QH, Ji QL, Huang DD, Zhao L, Xiao YT. Chemical conversion of human lung fibroblasts into neuronal cells. Int J Mol Med 2018;41:1463-1468 https://doi.org/10.3892/ijmm.2018.3375
- Shaulian E, Resnitzky D, Shifman O, Blandino G, Amsterdam A, Yayon A, Oren M. Induction of Mdm2 and enhancement of cell survival by bFGF. Oncogene 1997;15:2717-2725 https://doi.org/10.1038/sj.onc.1201453
- Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009;5:491-503 https://doi.org/10.1016/j.stem.2009.09.012
- He S, Guo Y, Zhang Y, Li Y, Feng C, Li X, Lin L, Guo L, Wang H, Liu C, Zheng Y, Luo C, Liu Q, Wang F, Sun H, Liang L, Li L, Su H, Chen J, Pei D, Zheng H. Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo. Cell Regen 2015;4:12
- Boersma MC, Dresselhaus EC, De Biase LM, Mihalas AB, Bergles DE, Meffert MK. A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis. J Neurosci 2011;31:5414-5425 https://doi.org/10.1523/JNEUROSCI.2456-10.2011
- Hajmirza A, Emadali A, Gauthier A, Casasnovas O, Gressin R, Callanan MB. BET family protein BRD4: an emerging actor in NFκB signaling in inflammation and cancer. Biomedicines 2018;6:16
- Masserdotti G, Gascon S, Gotz M. Direct neuronal reprogramming: learning from and for development. Development 2016;143:2494-2510 https://doi.org/10.1242/dev.092163
- Irwin RP, Allen CN. Simultaneous electrophysiological recording and calcium imaging of suprachiasmatic nucleus neurons. J Vis Exp 2013;(82):50794
- Fernandes GS, Singh RD, Kim KK. Generation of a pure culture of neuron-like cells with a glutamatergic phenotype from mouse astrocytes. Biomedicines 2022;10:928
- Pre D, Nestor MW, Sproul AA, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle SA, Arancio O. A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). PLoS One 2014;9:e103418
- Filippakopoulos P, Knapp S. Targeting bromodomains: epigenetic readers of lysine acetylation. Nat Rev Drug Discov 2014;13:337-356 https://doi.org/10.1038/nrd4286
- Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov 2014;13:673-691 https://doi.org/10.1038/nrd4360
- Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sanchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noel PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Hessmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med 2015;21:1163-1171 https://doi.org/10.1038/nm.3952
- Korb E, Herre M, Zucker-Scharff I, Darnell RB, Allis CD. BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice. Nat Neurosci 2015;18:1464-1473 https://doi.org/10.1038/nn.4095
- Dresselhaus EC, Meffert MK. Cellular specificity of NF-κB function in the nervous system. Front Immunol 2019;10:1043
- Rosenberg SS, Spitzer NC. Calcium signaling in neuronal development. Cold Spring Harb Perspect Biol 2011;3:a004259
- Macleod GT. Imaging and analysis of nonratiometric calcium indicators at the Drosophila larval neuromuscular junction. Cold Spring Harb Protoc 2012;2012:802-809 https://doi.org/10.1101/pdb.prot070110
- Berridge MJ. Neuronal calcium signaling. Neuron 1998;21:13-26 https://doi.org/10.1016/S0896-6273(00)80510-3
- Greer PL, Greenberg ME. From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron 2008;59:846-860 https://doi.org/10.1016/j.neuron.2008.09.002
- Fischer I, Dulin JN, Lane MA. Transplanting neural progenitor cells to restore connectivity after spinal cord injury. Nat Rev Neurosci 2020;21:366-383 https://doi.org/10.1038/s41583-020-0314-2