Annals of Occupational and Environmental Medicine

  • Volume 35
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  • Pages.2.1-2.15
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  • 2023
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  • 1225-3618(pISSN)
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  • 2052-4374(eISSN)
The Korean Society of Occupational & Environmental Medicine (대한직업환경의학회)
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Relationship between shellfish consumption and urinary phthalate metabolites: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017)

  • Jisoo Kang (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital) ;
  • Seong-yong Cho (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital) ;
  • Jinseok Kim (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital) ;
  • Seongyong Yoon (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital) ;
  • Jong-min An (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital) ;
  • Gayoung Kim (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital) ;
  • Si young Kim (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital)
  • Received : 2022.09.21
  • Accepted : 2023.01.02
  • Published : 2023.12.31
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Abstract

Background: Phthalates are endocrine disrupting chemicals that are widely used in the production of items of daily life such as in polyvinylchloride plastics, insecticides, and medical devices. This study aimed to determine the association between phthalate exposure and shellfish consumption using data from the Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017), which is a nationally representative survey. Methods: In this study, we analyzed the KoNEHS cycle 3 data of 3,333 (1,526 men and 1,807 women) adults aged more than 19 years. Data related to the variables of sociodemographic factors, health-related behaviors, dietary factors, seafood consumption frequency, and urinary phthalate metabolites concentrations were collected. The concentrations of urinary phthalate metabolites of all the participants were divided into quartiles to define high and low concentration groups based on the 75th percentile concentration. A χ2 test was conducted to analyze the distribution of independent variables. To analyze the relationship between shellfish consumption and phthalate exposure, the odds ratios (ORs) were calculated using logistic regression analysis. Results: Total adults with shellfish consumption frequency of over once a week showed the following adjusted ORs for high concentrations of the following metabolites compared with the group that consumed shellfish once a week or less: 1.43 (95% confidence interval [CI]: 1.01-2.06) for mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), 1.43 (95% CI: 1.01-2.03) for mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), 1.57 (95% CI: 1.10-2.24) for ∑di-2-ethylhexyl phthalate (∑DEHP), 2.01 (95% CI: 1.46-2.77) for mono-carboxyoctyl phthalate (MCOP), 1.56 (95% CI: 1.11-2.18) for mono-carboxy-isononly phthalate (MCNP), and 2.57 (95% CI: 1.85-3.56) for mono (3-carboxypropyl) phthalate (MCPP). Conclusions: The concentrations of urinary phthalate metabolites (MEOHP, MECPP, ∑DEHP, MCOP, MCNP, and MCPP) were higher in adults with a higher frequency of shellfish consumption.

Keywords

Acknowledgement

We appreciate National Institute of Environmental Research making available the raw data of Korean National Environmental Health Survey.

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