Advances in nano research

  • 제14권6호
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  • Pages.507-519
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  • 2023
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  • 2287-237X(pISSN)
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  • 2287-2388(eISSN)
테크노프레스 (Techno-Press)
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DOI QR코드

DOI QR Code

Antibacterial mesoporous Sr-doped hydroxyapatite nanorods synthesis for biomedical applications

  • Gopalu Karunakaran (Institute for Applied Chemistry, Department of Fine Chemistry, Seoul National University of Science and Technology (Seoul Tech)) ;
  • Eun-Bum Cho (Institute for Applied Chemistry, Department of Fine Chemistry, Seoul National University of Science and Technology (Seoul Tech)) ;
  • Keerthanaa Thirumurugan (Department of Biotechnology, K.S. Rangasamy College of Arts and Science (Autonomous)) ;
  • Govindan Suresh Kumar (Department of Physics, K.S. Rangasamy College of Arts and Science (Autonomous)) ;
  • Evgeny Kolesnikov (Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology "MISiS") ;
  • Selvakumar Boobalan (Department of Biotechnology, K.S. Rangasamy College of Arts and Science (Autonomous))
  • 투고 : 2021.12.07
  • 심사 : 2023.04.10
  • 발행 : 2023.06.25
⟨ 이전 논문 다음 논문 ⟩

초록

Postsurgical infections are caused by implant-related pathogenic microorganisms that lead to graft rejection. Hence, an intrinsically antibacterial material is required to produce a biocompatible biomaterial with osteogenic properties that could address this major issue. Hence, this current research aims to make strontium-doped hydroxyapatite nanorods (SrHANRs) via an ethylene diamine tetraacetic acid (EDTA)-enable microwave mediated method using Anodontia alba seashells for biomedical applications. This investigation also perceives that EDTA acts as a soft template to accomplish Sr-doping and mesoporous structures in pure hydroxyapatite nanorods (HANRs). The X-ray diffraction (XRD) and transmission electron microscopy (TEM) analysis reveals the crystalline and mesoporous structures, and Brunauer-Emmett-Teller (BET) indicates the surface area of all the samples, including pure HANRs and doped HANRs. In addition, the biocidal ability was tested using various implant-related infectious bacteria pathogens, and it was discovered that Sr-doped HANRs have excellent biocidal properties. Furthermore, toxicity evaluation using zebrafish reports the non-toxic nature of the produced HANRs. Incorporating Sr2+ ions into the HAp lattice would enhance biocompatibility, biocidal activity, and osteoconductive properties. As a result, the biocompatible HANRs materials synthesized with Sr-dopants may be effective in bone regeneration and antibacterial in-built implant applications.

키워드

과제정보

E.-B. Cho and Gopalu Karunakaran were supported by Brain Pool Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (Grant no. 2022H1D3A2A02044281).

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