DOI QR코드

DOI QR Code

Bile Acid and Gastrointestinal Cancer

담즙산과 위장관암

  • Seon-Young Park (Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School)
  • 박선영 (전남대학교 의과대학 내과학교실 소화기내과)
  • Received : 2023.04.03
  • Accepted : 2023.04.10
  • Published : 2023.04.20

Abstract

Keywords

References

  1. Peng S, Huo X, Rezaei D, et al. In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids. Am J Physiol Gastrointest Liver Physiol 2014;307:G129-G139. https://doi.org/10.1152/ajpgi.00085.2014 
  2. Guan B, Li H, Yang Z, Hoque A, Xu X. Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts. Cancer 2013;119:1321-1329. https://doi.org/10.1002/cncr.27910 
  3. Abe I, Suzuki K, Kimura Y, et al. Enhancement of DNA hypomethylation alterations by gastric and bile acids promotes chromosomal instability in Barrett's epithelial cell line. Sci Rep 2022;12:20710. https://doi.org/10.1038/s41598-022-25279-y 
  4. Matsuhisa T, Arakawa T, Watanabe T, et al. Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: a multi-center study of 2283 cases. Dig Endosc 2013;25:519-525. https://doi.org/10.1111/den.12030 
  5. Cao W, Tian W, Hong J, et al. Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Physiol Gastrointest Liver Physiol 2013;304:G322-G327. https://doi.org/10.1152/ajpgi.00263.2012 
  6. Yu JH, Zheng JB, Qi J, et al. Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. Int J Oncol 2019;54:879-892. https://doi.org/10.3892/ijo.2019.4692 
  7. Xu X, Cheng J, Luo S, et al. Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach. Biochem Biophys Res Commun 2020;524:649-655. https://doi.org/10.1016/j.bbrc.2020.01.159 
  8. Zeng H, Safratowich BD, Cheng WH, Larson KJ, Briske-Anderson M. Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction. Molecules 2022;27:723. https://doi.org/10.3390/molecules27030723 
  9. Bernstein H, Bernstein C. Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system. Exp Biol Med (Maywood) 2023;248:79-89. https://doi.org/10.1177/15353702221131858 
  10. Li S, Qu X, Zhang L, et al. Serum total bile acids in relation to gastrointestinal cancer risk: a retrospective study. Front Oncol 2022;12:859716. https://doi.org/10.3389/fonc.2022.859716