Journal of Digestive Cancer Research

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
권호 표지
DOI QR코드

DOI QR Code

Proper Oral Hygiene and Dental Care for Cancer Patients

항암치료를 받는 환자의 구강관리 및 치과 치료

  • Seung-Joo Nam (Department of Internal Medicine, Kangwon National University School of Medicine)
  • 남승주 (강원대학교 의과대학 내과학교실)
  • Received : 2022.09.05
  • Accepted : 2023.04.13
  • Published : 2023.04.20
Download PDF
⟨ Previous Next ⟩

Abstract

Oral complications, such as mucositis, infection, or xerostomia, are common in patients with cancer receiving chemotherapy or radiotherapy. These complications can cause pain, leading to increased consumption of analgesics, poor oral intake, malnutrition, and even a need for parenteral nutrition. Moreover, they can sometimes interrupt the treatment plan. This review focuses on the proper management and prevention of oral complications that are common in patients with cancer receiving chemotherapy or radiotherapy.

Keywords

References

  1. Mercadante S, Aielli F, Adile C, et al. Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients. Support Care Cancer 2015;23:3249-3255. https://doi.org/10.1007/s00520-015-2720-y
  2. Pulito C, Cristaudo A, Porta C, et al. Oral mucositis: the hidden side of cancer therapy. J Exp Clin Cancer Res 2020;39:210. https://doi.org/10.1186/s13046-020-01715-7
  3. Korean Society of Gastrointestinal Cancer Research; The Korean Society of Clinical Nutrition. Gastrointestinal nutritional oncology. Seoul: Medbook, 2013.
  4. Keefe DM, Schubert MM, Elting LS, et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 2007;109:820-831. https://doi.org/10.1002/cncr.22484
  5. Peterson DE, Boers-Doets CB, Bensadoun RJ, Herrstedt J; ESMO Guidelines Committee. Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and followup. Ann Oncol 2015;26 Suppl 5:v139-v151. https://doi.org/10.1093/annonc/mdv202
  6. Mahood DJ, Dose AM, Loprinzi CL, et al. Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. J Clin Oncol 199;9:449-452. https://doi.org/10.1200/JCO.1991.9.3.449
  7. Cascinu S, Fedeli A, Fedeli SL, Catalano G. Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis. Eur J Cancer B Oral Oncol 1994;30B:234-236. https://doi.org/10.1016/0964-1955(94)90003-5
  8. Sorensen JB, Skovsgaard T, Bork E, Damstrup L, Ingeberg S. Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracilbased chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer 2008;112:1600-1606. https://doi.org/10.1002/cncr.23328
  9. Katranci N, Ovayolu N, Ovayolu O, Sevinc A. Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - a randomized controlled trial. Eur J Oncol Nurs 2012;16:339-344. https://doi.org/10.1016/j.ejon.2011.07.008
  10. Correa MEP, Cheng KKF, Chiang K, et al. Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 2020;28:2449-2456. https://doi.org/10.1007/s00520-019-05217-x
  11. Riley P, Glenny AM, Worthington HV, Littlewood A, Clarkson JE, McCabe MG. Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Cochrane Database Syst Rev 2015;2015:CD011552. https://doi.org/10.1002/14651858.CD011552.pub2
  12. Rocke LK, Loprinzi CL, Lee JK, et al. A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil-related stomatitis. Cancer 1993;72:2234-2238. https://doi.org/10.1002/1097-0142(19931001)72:7<2234::aidcncr2820720728>3.0.co;2-n
  13. Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004;351:2590-2598. https://doi.org/10.1056/NEJMoa040125
  14. Hong CHL, Gueiros LA, Fulton JS, et al. Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 2019;27:3949-3967. https://doi.org/10.1007/s00520-019-04848-4
  15. Vistoso Monreal A, Polonsky G, Shiboski C, Sankar V, Villa A. Salivary gland dysfunction secondary to cancer treatment. Front Oral Health 2022;3:907778. https://doi.org/10.3389/froh.2022.907778
  16. Pinna R, Campus G, Cumbo E, Mura I, Milia E. Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence, and management of the oral damage. Ther Clin Risk Manag 2015;11:171-188. https://doi.org/10.2147/TCRM.S70652
  17. Lerman MA, Laudenbach J, Marty FM, Baden LR, Treister NS. Management of oral infections in cancer patients. Dent Clin North Am 2008;52:129-153, ix. https://doi.org/10.1016/j.cden.2007.10.006