Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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Time Perception and Memory in Mild Cognitive Impairment and Alzheimer's Disease: A Preliminary Study

  • Sung-Ho Woo (Institute of Interdisciplinary Brain Science, Dongguk University College of Medicine) ;
  • Jarang Hahm (Department of Neurology, Dongguk University Ilsan Hospital) ;
  • Jeong-Sug Kyong (Institute of Interdisciplinary Brain Science, Dongguk University College of Medicine) ;
  • Hang-Rai Kim (Institute of Interdisciplinary Brain Science, Dongguk University College of Medicine) ;
  • Kwang Ki Kim (Institute of Interdisciplinary Brain Science, Dongguk University College of Medicine)
  • Received : 2023.09.19
  • Accepted : 2023.11.06
  • Published : 2023.10.31
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Abstract

Background and Purpose: Episodic memory is a system that receives and stores information about temporally dated episodes and their interrelations. Our study aimed to investigate the relevance of episodic memory to time perception, with a specific focus on simultaneity/order judgment. Methods: Experiment 1 employed the simultaneity judgment task to discern differences in time perception between patients with mild cognitive impairment or dementia, and age-matched normals. A mathematical analysis capable of estimating subjects' time processing was utilized to identify the sensory and decisional components of temporal order and simultaneity judgment. Experiment 2 examined how differences in temporal perception relate to performance in temporal order memory, in which time delays play a critical role. Results: The temporal decision windows for both temporal order and simultaneity judgments exhibited marginal differences between patients with episodic memory impairment, and their healthy counterparts (p = 0.15, t(22) = 1.34). These temporal decision windows may be linked to the temporal separation of events in episodic memory (Pearson's ρ = -0.53, p = 0.05). Conclusions: Based on our findings, the frequency of visual events accumulated and encoded in the working memory system in the patients' and normal group appears to be approximately (5.7 and 11.2) Hz, respectively. According to the internal clock model, a lower frequency of event pulses tends to result in underestimation of event duration, which phenomenon might be linked to the observed time distortions in patients with dementia.

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References

  1. Tulving E. Elements of episodic memory. New York: Oxford University Press, 1985. 
  2. Garcia-Perez MA, Alcala-Quintana R. Chapter 12. Perceived temporal order and simultaneity: beyond psychometric functions. In: Vatakis A, Balci F, Di Luca M, Correa A, editors. Timing and Time Perception: Procedures, Measures, & Applications. Boston: Brill, 2018;263-294. 
  3. Vargha-Khadem F, Gadian DG, Watkins KE, Connelly A, Van Paesschen W, Mishkin M. Differential effects of early hippocampal pathology on episodic and semantic memory. Science 1997;277:376-380.
  4. Steinvorth S, Levine B, Corkin S. Medial temporal lobe structures are needed to re-experience remote autobiographical memories: evidence from H.M. and W.R. Neuropsychologia 2005;43:479-496.
  5. Fortin NJ, Wright SP, Eichenbaum H. Recollection-like memory retrieval in rats is dependent on the hippocampus. Nature 2004;431:188-191.
  6. Ergorul C, Eichenbaum H. The hippocampus and memory for "what," "where," and "when". Learn Mem 2004;11:397-405.
  7. O'Keefe J, Dostrovsky J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 1971;34:171-175.
  8. O'Keefe J. Place units in the hippocampus of the freely moving rat. Exp Neurol 1976;51:78-109.
  9. MacDonald CJ, Lepage KQ, Eden UT, Eichenbaum H. Hippocampal "time cells" bridge the gap in memory for discontiguous events. Neuron 2011;71:737-749.
  10. Umbach G, Kantak P, Jacobs J, Kahana M, Pfeiffer BE, Sperling M, et al. Time cells in the human hippocampus and entorhinal cortex support episodic memory. Proc Natl Acad Sci USA 2020;117:28463-28474.
  11. Kraus BJ, Robinson RJ 2nd, White JA, Eichenbaum H, Hasselmo ME. Hippocampal "time cells": time versus path integration. Neuron 2013;78:1090-1101.
  12. Josephs KA, Dickson DW, Tosakulwong N, Weigand SD, Murray ME, Petrucelli L, et al. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. Lancet Neurol 2017;16:917-924. 
  13. Zarow C, Vinters HV, Ellis WG, Weiner MW, Mungas D, White L, et al. Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia. Ann Neurol 2005;57:896-903.
  14. Jack CR Jr, Dickson DW, Parisi JE, Xu YC, Cha RH, O'Brien PC, et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 2002;58:750-757.
  15. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011;7:263-269.
  16. Grewal RP. Awareness of time in dementia of the Alzheimer type. Psychol Rep 1995;76:717-718.
  17. El Haj M, Kapogiannis D. Time distortions in Alzheimer's disease: a systematic review and theoretical integration. NPJ Aging Mech Dis 2016;2:16016.
  18. Nichelli P, Venneri A, Molinari M, Tavani F, Grafman J. Precision and accuracy of subjective time estimation in different memory disorders. Brain Res Cogn Brain Res 1993;1:87-93.
  19. Carrasco MC, Guillem MJ, Redolat R. Estimation of short temporal intervals in Alzheimer's disease. Exp Aging Res 2000;26:139-151.
  20. Caselli L, Iaboli L, Nichelli P. Time estimation in mild Alzheimer's disease patients. Behav Brain Funct 2009;5:32.
  21. Papagno C, Allegra A, Cardaci M. Time estimation in Alzheimer's disease and the role of the central executive. Brain Cogn 2004;54:18-23.
  22. Ulrich R. Threshold models of temporal-order judgments evaluated by a ternary response task. Percept Psychophys 1987;42:224-239.
  23. Tolentino JC, Pirogovsky E, Luu T, Toner CK, Gilbert PE. The effect of interference on temporal order memory for random and fixed sequences in nondemented older adults. Learn Mem 2012;19:251-255.
  24. Reisberg B, Ferris SH, de Leon MJ, Crook T. The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1136-1139.
  25. Morris JC. The clinical dementia rating (CDR): current version and scoring rules. Neurology 1993;43:2412-2414.
  26. Petersen RC. Clinical practice. Mild cognitive impairment. N Engl J Med 2011;364:2227-2234.
  27. Sternberg S, Knoll RL. The perception of temporal order: fundamental issues and a general model. In: Kornblum S, editor. Attention and Performance IV. New York: Academic Press, 1973;629-685. 
  28. Alcala-Quintana R, Garcia-Perez MA. Fitting model-based psychometric functions to simultaneity and temporal-order judgment data: MATLAB and R routines. Behav Res Methods 2013;45:972-998.
  29. Treisman M. Temporal discrimination and the indifference interval. Implications for a model of the "internal clock". Psychol Monogr 1963;77:1-31.
  30. Allman MJ, Teki S, Griffiths TD, Meck WH. Properties of the internal clock: first- and second-order principles of subjective time. Annu Rev Psychol 2014;65:743-771.
  31. Church RM. Properties of the internal clock. Ann N Y Acad Sci 1984;423:566-582.
  32. Thoenes S, Oberfeld D. Meta-analysis of time perception and temporal processing in schizophrenia: Differential effects on precision and accuracy. Clin Psychol Rev 2017;54:44-64.
  33. Wasserstein RL, Schirm AL, Lazar NA. Moving to a world beyond "p<0.05". Am Stat 2019;73 Suppl 1:1-19.