Acknowledgement
This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (2022M3A9D3016848), and by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Education (2020R1F1A1073692 and 2022R1F1A1075235).
References
- Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992;71:649-662. https://doi.org/10.1016/0092-8674(92)90598-7
- Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998;92:83-92. https://doi.org/10.1016/S0092-8674(00)80901-0
- Koretzky GA, Abtahian F, Silverman MA. SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond. Nat Rev Immunol 2006;6:67-78. https://doi.org/10.1038/nri1750
- Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 1993;11:191-212. https://doi.org/10.1146/annurev.iy.11.040193.001203
- Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, et al. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity 2005;23: 575-585. https://doi.org/10.1016/j.immuni.2005.10.007
- Iezzi G, Karjalainen K, Lanzavecchia A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 1998;8:89-95. https://doi.org/10.1016/S1074-7613(00)80461-6
- La Gruta NL, Liu H, Dilioglou S, Rhodes M, Wiest DL, Vignali DA. Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation. J Immunol 2004;172:3662-3669. https://doi.org/10.4049/jimmunol.172.6.3662
- Suhoski MM, Golovina TN, Aqui NA, Tai VC, Varela-Rohena A, Milone MC, et al. Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. Mol Ther 2007;15:981-988. https://doi.org/10.1038/mt.sj.6300134
- Lawlor N, Nehar-Belaid D, Grassmann JD, Stoeckius M, Smibert P, Stitzel ML, et al. Single cell analysis of blood mononuclear cells stimulated through either LPS or anti-CD3 and anti-CD28. Front Immunol 2021;12:636720.
- El Hentati FZ, Gruy F, Iobagiu C, Lambert C. Variability of CD3 membrane expression and T cell activation capacity. Cytometry B Clin Cytom 2010;78:105-114. https://doi.org/10.1002/cyto.b.20496
- Liu H, Rhodes M, Wiest DL, Vignali DA. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 2000;13:665-675. https://doi.org/10.1016/S1074-7613(00)00066-2
- Jiao J, Zhao X, Hou R, Wang Y, Chang W, Liang N, et al. Comparison of two commonly used methods for stimulating T cells. Biotechnol Lett 2019;41:1361-1371. https://doi.org/10.1007/s10529-019-02743-w
- Olsen I, Sollid LM. Pitfalls in determining the cytokine profile of human T cells. J Immunol Methods 2013;390:106-112. https://doi.org/10.1016/j.jim.2013.01.015
- Dong C. Cytokine regulation and function in T cells. Annu Rev Immunol 2021;39:51-76. https://doi.org/10.1146/annurev-immunol-061020-053702
- Han S, Tie X, Meng L, Wang Y, Wu A. PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells. PLoS One 2013;8:e76717.