Journal of Cardiovascular Imaging

  • 제31권2호
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  • Pages.71-82
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  • 2023
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
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Dynamic Cardiac Magnetic Resonance Fingerprinting During Vasoactive Breathing Maneuvers: First Results

  • Luuk H.G.A. Hopman (Research Institute of the McGill University Health Center) ;
  • Elizabeth Hillier (Research Institute of the McGill University Health Center) ;
  • Yuchi Liu (Department of Biomedical Engineering, Case Western Reserve University) ;
  • Jesse Hamilton (Department of Biomedical Engineering, Case Western Reserve University) ;
  • Kady Fischer (Department of Anaesthesiology and Pain Medicine, Bern University Hospital, Inselspital, University of Bern) ;
  • Nicole Seiberlich (Department of Biomedical Engineering, Case Western Reserve University) ;
  • Matthias G. Friedrich (Research Institute of the McGill University Health Center)
  • 투고 : 2022.07.04
  • 심사 : 2022.10.10
  • 발행 : 2023.04.27
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초록

BACKGROUND: Cardiac magnetic resonance fingerprinting (cMRF) enables simultaneous mapping of myocardial T1 and T2 with very short acquisition times. Breathing maneuvers have been utilized as a vasoactive stress test to dynamically characterize myocardial tissue in vivo. We tested the feasibility of sequential, rapid cMRF acquisitions during breathing maneuvers to quantify myocardial T1 and T2 changes. METHODS: We measured T1 and T2 values using conventional T1 and T2-mapping techniques (modified look locker inversion [MOLLI] and T2-prepared balanced-steady state free precession), and a 15 heartbeat (15-hb) and rapid 5-hb cMRF sequence in a phantom and in 9 healthy volunteers. The cMRF5-hb sequence was also used to dynamically assess T1 and T2 changes over the course of a vasoactive combined breathing maneuver. RESULTS: In healthy volunteers, the mean myocardial T1 of the different mapping methodologies were: MOLLI 1,224 ± 81 ms, cMRF15-hb 1,359 ± 97 ms, and cMRF5-hb 1,357 ± 76 ms. The mean myocardial T2 measured with the conventional mapping technique was 41.7 ± 6.7 ms, while for cMRF15-hb 29.6 ± 5.8 ms and cMRF5-hb 30.5 ± 5.8 ms. T2 was reduced with vasoconstriction (post-hyperventilation compared to a baseline resting state) (30.15 ± 1.53 ms vs. 27.99 ± 2.07 ms, p = 0.02), while T1 did not change with hyperventilation. During the vasodilatory breath-hold, no significant change of myocardial T1 and T2 was observed. CONCLUSIONS: cMRF5-hb enables simultaneous mapping of myocardial T1 and T2, and may be used to track dynamic changes of myocardial T1 and T2 during vasoactive combined breathing maneuvers.

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과제정보

This Fingerprinting study has been initiated by Matthias Friedrich with financial support from the McGill University Health Centre Foundation through the Courtois CMR Research Program.

참고문헌

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