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Dynamic Cardiac Magnetic Resonance Fingerprinting During Vasoactive Breathing Maneuvers: First Results

  • Luuk H.G.A. Hopman (Research Institute of the McGill University Health Center) ;
  • Elizabeth Hillier (Research Institute of the McGill University Health Center) ;
  • Yuchi Liu (Department of Biomedical Engineering, Case Western Reserve University) ;
  • Jesse Hamilton (Department of Biomedical Engineering, Case Western Reserve University) ;
  • Kady Fischer (Department of Anaesthesiology and Pain Medicine, Bern University Hospital, Inselspital, University of Bern) ;
  • Nicole Seiberlich (Department of Biomedical Engineering, Case Western Reserve University) ;
  • Matthias G. Friedrich (Research Institute of the McGill University Health Center)
  • Received : 2022.07.04
  • Accepted : 2022.10.10
  • Published : 2023.04.27

Abstract

BACKGROUND: Cardiac magnetic resonance fingerprinting (cMRF) enables simultaneous mapping of myocardial T1 and T2 with very short acquisition times. Breathing maneuvers have been utilized as a vasoactive stress test to dynamically characterize myocardial tissue in vivo. We tested the feasibility of sequential, rapid cMRF acquisitions during breathing maneuvers to quantify myocardial T1 and T2 changes. METHODS: We measured T1 and T2 values using conventional T1 and T2-mapping techniques (modified look locker inversion [MOLLI] and T2-prepared balanced-steady state free precession), and a 15 heartbeat (15-hb) and rapid 5-hb cMRF sequence in a phantom and in 9 healthy volunteers. The cMRF5-hb sequence was also used to dynamically assess T1 and T2 changes over the course of a vasoactive combined breathing maneuver. RESULTS: In healthy volunteers, the mean myocardial T1 of the different mapping methodologies were: MOLLI 1,224 ± 81 ms, cMRF15-hb 1,359 ± 97 ms, and cMRF5-hb 1,357 ± 76 ms. The mean myocardial T2 measured with the conventional mapping technique was 41.7 ± 6.7 ms, while for cMRF15-hb 29.6 ± 5.8 ms and cMRF5-hb 30.5 ± 5.8 ms. T2 was reduced with vasoconstriction (post-hyperventilation compared to a baseline resting state) (30.15 ± 1.53 ms vs. 27.99 ± 2.07 ms, p = 0.02), while T1 did not change with hyperventilation. During the vasodilatory breath-hold, no significant change of myocardial T1 and T2 was observed. CONCLUSIONS: cMRF5-hb enables simultaneous mapping of myocardial T1 and T2, and may be used to track dynamic changes of myocardial T1 and T2 during vasoactive combined breathing maneuvers.

Keywords

Acknowledgement

This Fingerprinting study has been initiated by Matthias Friedrich with financial support from the McGill University Health Centre Foundation through the Courtois CMR Research Program.

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