Annals of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지)

The Korean Association of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회)
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Littoral cell angiomas: Benign lesion with a penchant for visceral malignancies

  • Snigdha Gulati (Department of Cardio-Thoracic and Neurosurgery, All India Institute of Medical Sciences (AIIMS)) ;
  • Hoonbae Jeon (Division of Hepato-Pancreato-Biliary & Abdominal Transplant Surgery, Tulane University School of Medicine) ;
  • Adarsh Vijay (Division of Hepato-Pancreato-Biliary & Abdominal Transplant Surgery, Tulane University School of Medicine)
  • Received : 2022.08.05
  • Accepted : 2022.09.07
  • Published : 2023.02.28
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Abstract

Littoral cell angiomas are rare vascular tumors of the spleen. Because of their rarity, unclear etiopathogenesis, and association with other malignancies, these tumors can pose diagnostic and therapeutic challenges. Due to paucity of published literature on this entity often limited to case reports, relevant data on this topic were procured and synthesized with the aid of a comprehensive Medline search in addition to oncologic, pathologic, radiologic, and surgical literature review on littoral cell angiomas. This article provides an in-depth review into postulated etiopathogenesis, pathology, clinical manifestations, associated malignancies, and prognostic features of littoral cell angiomas.

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References

  1. Falk S, Stutte HJ, Frizzera G. Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation. Am J Surg Pathol 1991;15:1023-1033.  https://doi.org/10.1097/00000478-199111000-00001
  2. Gakenheimer-Smith L, Mohlman J, VandenHeuvel K, Jackson WD, Thomsen W, Stevenson A, et al. A novel presentation of littoral cell angioma and lymphatic malformations in a neonate. Pediatrics 2018;141(Suppl 5):S520-S525.  https://doi.org/10.1542/peds.2017-2782
  3. Priego P, Rodriguez Velasco G, Griffith PS, Fresneda V. Littoral cell angioma of the spleen. Clin Transl Oncol 2008;10:61-63.  https://doi.org/10.1007/s12094-008-0155-3
  4. Espanol I, Lerma E, Fumanal V, Palmer J, Roca M, Domingo-Albos A, et al. Littoral cell angioma with severe thrombocytopenia. Ann Hematol 2000;79:46-49.  https://doi.org/10.1007/s002770050009
  5. Schneider G, Uder M, Altmeyer K, Bonkhoff H, Gruber M, Kramann B. Littoral cell angioma of the spleen: CT and MR imaging appearance. Eur Radiol 2000;10:1395-1400.  https://doi.org/10.1007/s003300000345
  6. Zhang YH, Liu LM, Wang WP, Ding H, Wang XN, Xia HS. Littoral cell angioma of the spleen: sonographic-pathologic comparison. J Ultrasound Med 2013;32:691-697.  https://doi.org/10.7863/jum.2013.32.4.691
  7. Veillon DM, Williams RB, Sardenga LJ, Harrison GK, Cotelingam JD. 'Little' littoral cell angioma of the spleen. Am J Surg Pathol 2000;24:306-307.  https://doi.org/10.1097/00000478-200002000-00023
  8. Truong V, Finch R, Martin B, Buzacott K, Singh M, Patel B. Littoral cell angioma of spleen. ANZ J Surg 2019;89:E158-E159.  https://doi.org/10.1111/ans.14193
  9. O'Malley DP, Kim YS, Weiss LM. Distinctive immunohistochemical staining in littoral cell angioma using ERG and WT-1. Ann Diagn Pathol 2015;19:143-145.  https://doi.org/10.1016/j.anndiagpath.2015.02.007
  10. Tan YM, Chuah KL, Wong WK. Littoral cell angioma of the spleen. Ann Acad Med Singap 2004;33:524-526.  https://doi.org/10.47102/annals-acadmedsg.V33N4p524
  11. Muhlfeld AS, Eitner F, Perez-Bouza A, Knuechel R, Heintz B, Floege J. Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient. Am J Kidney Dis 2008;52:e11-e14.  https://doi.org/10.1053/j.ajkd.2008.01.033
  12. Gardner JA, Devitt K. Incidental littoral cell angioma in refractory immune thrombocytopenic purpura. Blood 2017;129:1564. 
  13. Ercin C, Gurbuz Y, Hacihanefioglu A, Turgut Karakaya A. Multiple littoral cell angioma of the spleen in a case of myelodysplastic syndrome. Hematology 2005;10:141-144.  https://doi.org/10.1080/10245330400026121
  14. Mac New HG, Fowler CL. Partial splenectomy for littoral cell angioma. J Pediatr Surg 2008;43:2288-2290.  https://doi.org/10.1016/j.jpedsurg.2008.07.031
  15. Cordesmeyer S, Putzler M, Titze U, Paulus H, Hoffmann MW. Littoral cell angioma of the spleen in a patient with previous pulmonary sarcoidosis: a TNF-α related pathogenesis? World J Surg Oncol 2011;9:106. 
  16. Gorman D, Bergstrom R. Littoral cell angioma in a patient with Ehlers-Danlos syndrome on biologic immunosuppression for psoriatic arthritis. Int J Case Rep Images 2016;7:800-804. 
  17. Collins GL, Morgan MB, Taylor FM 3rd. Littoral cell angiomatosis with poorly differentiated adenocarcinoma of the lung. Ann Diagn Pathol 2003;7:54-59.  https://doi.org/10.1053/adpa.2003.50009
  18. Roldan-Vasquez E , Roldan-Vasquez A, Jarrin-Estupinan X, Roldan-Crespo J. Case report: Infrequent littoral cell angioma of the spleen. Int J Surg Case Rep 2021;85:106242. 
  19. Ziske C, Meybehm M, Sauerbruch T, Schmidt-Wolf IG. Littoral cell angioma as a rare cause of splenomegaly. Ann Hematol 2001;80:45-48.  https://doi.org/10.1007/s002770000223
  20. Gupta MK, Levin M, Aguilera NS, Pastores GM. Littoral cell angioma of the spleen in a patient with Gaucher disease. Am J Hematol 2001;68:61-62.  https://doi.org/10.1002/ajh.1151
  21. Forest F, Duband S, Clemenson A, Peoc'h M. Traumatic subcapsular splenic hematoma revealing littoral cell angioma and Gaucher's disease. Ann Hematol 2010;89:1061-1062.  https://doi.org/10.1007/s00277-010-0909-1
  22. Anton-Pacheco J, Ayuso RM, Cano I, Martinez MA, Cuadros J, Berchi FJ. Splenic littoral cell angioma in an infant. J Pediatr Surg 2000;35:508-509.  https://doi.org/10.1016/S0022-3468(00)90225-2
  23. Sarandria JJ, Escano M, Kamangar F, Farooqui SO, Montgomery E, Cunningham SC. Littoral cell angioma: gastrointestinal associations. Gastrointest Cancer Res 2014;7:63-64. 
  24. Johansson J, Bjornsson B, Ignatova S, Sandstrom P, Ekstedt M. Littoral cell angioma in a patient with Crohn's disease. Case Rep Gastrointest Med 2015;2015:474969. 
  25. Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, et al. Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy. Diagn Cytopathol 2011;39:318-322.  https://doi.org/10.1002/dc.21384
  26. Bhatt S, Huang J, Dogra V. Littoral cell angioma of the spleen. AJR Am J Roentgenol 2007;188:1365-1366.  https://doi.org/10.2214/AJR.06.1157
  27. Pilz JB, Sperschneider T, Lutz T, Loosli B, Maurer CA. Littoral cell angioma in main and accessory intrapancreatic spleen presenting as splenic rupture. Am J Surg 2011;201:e15-e17.  https://doi.org/10.1016/j.amjsurg.2009.11.013
  28. Steensma DP, Morice WG. Littoral cell angioma associated with portal hypertension and resected colon cancer. Acta Haematol 2000;104:131-134.  https://doi.org/10.1159/000039747
  29. Opatrny V, Treska V, Waloschek T, Molacek J. Littoral cell angioma of the spleen: a case report. SAGE Open Med Case Rep 2020;8:2050313X20959874. 
  30. Bhavsar T, Wang C, Huang Y, Karachristos A, Inniss S. Littoral cell angiomas of the spleen associated with solid pseudopapillary tumor of the pancreas. World J Gastrointest Pathophysiol 2011;2:53-56.  https://doi.org/10.4291/wjgp.v2.i3.53
  31. Heese J, Bocklage T. Specimen fine-needle aspiration cytology of littoral cell angioma with histologic and immunohistochemical confirmation. Diagn Cytopathol 2000;22:39-44.  https://doi.org/10.1002/(SICI)1097-0339(200001)22:1<39::AID-DC11>3.0.CO;2-Q
  32. Floyd JD, Kaplan PA, Sauter ER, Perry MC, Doll DC. Patients with unusual bladder malignancies and a rare cause of splenomegaly. 3. Littoral cell angioma of the spleen in a patient with previous lymphoma. J Clin Oncol 2005;23:4460-4462.  https://doi.org/10.1200/JCO.2005.05.066
  33. Melzer N, Barth PJ, Muller KM, Foss HD, Krug U, Schilling M, et al. Rapidly progressive B-cell dominated inflammatory neuropathy and littoral cell angioma of the spleen associated with plasmablastic B-cell lymphoma. Leuk Lymphoma 2012;53:1242-1244.  https://doi.org/10.3109/10428194.2011.640677
  34. Marzetti A, Messina F, Prando D, Verza LA, Vacca U, Azabdaftari A, et al. Laparoscopic splenectomy for a littoral cell angioma of the spleen: case report. World J Clin Cases 2015;3:951-955.  https://doi.org/10.12998/wjcc.v3.i11.951
  35. Chatelain D, Bonte H, Guillevin L, Balladur P, Flejou JF. Small solitary littoral cell angioma associated with splenic marginal zone lymphoma and villous lymphocyte leukaemia in a patient with hepatitis C infection. Histopathology 2002;41:473-475.  https://doi.org/10.1046/j.1365-2559.2002.14313.x
  36. Yano H, Imasato M, Monden T, Okamoto S. Hand-assisted laparoscopic splenectomy for splenic vascular tumors: report of two cases. Surg Laparosc Endosc Percutan Tech 2003;13:286-289.  https://doi.org/10.1097/00129689-200308000-00014
  37. Harmon RL, Cerruto CA, Scheckner A. Littoral cell angioma: a case report and review. Curr Surg 2006;63:345-350.  https://doi.org/10.1016/j.cursur.2006.06.011
  38. Shah S, Wasnik A, Pandya A, Bude RO. Multimodality imaging findings in image-guided biopsy proven splenic littoral cell angioma: series of three cases. Abdom Imaging 2011;36:735-738.  https://doi.org/10.1007/s00261-011-9697-x
  39. Mohan V, Jones RC, Drake AJ 3rd, Daly PL, Shakir KM. Littoral cell angioma presenting as metastatic thyroid carcinoma to the spleen. Thyroid 2005;15:170-175.  https://doi.org/10.1089/thy.2005.15.170
  40. Yaney A, Jones D, Perry KA, Jhawar SR. Rare case of littoral cell angioma recognised on CT simulation for adjuvant radiation treatment for early stage breast cancer. BMJ Case Rep 2022;15:e248167. 
  41. Kranzfelder M, Bauer M, Richter T, Rudelius M, Huth M, Wagner P, et al. Littoral cell angioma and angiosarcoma of the spleen: report of two cases in siblings and review of the literature. J Gastrointest Surg 2012;16:863-867.  https://doi.org/10.1007/s11605-011-1773-6
  42. Ben-Izhak O, Bejar J, Ben-Eliezer S, Vlodavsky E. Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour. Histopathology 2001;39:469-475.  https://doi.org/10.1046/j.1365-2559.2001.01242.x
  43. Fernandez S, Cook GW, Arber DA. Metastasizing splenic littoral cell hemangioendothelioma. Am J Surg Pathol 2006;30:1036-1040.  https://doi.org/10.1097/00000478-200608000-00016
  44. Takayoshi K, Doi G, Tsuruta N, Yoshihiro T, Nio K, Tsuchihashi K, et al. Successful chemotherapeutic treatment for metastatic littoral cell angioma: a case report. Medicine (Baltimore) 2018;97:e0378. 
  45. Hu ZQ, A YJ, Sun QM, Li W, Li L. The splenic littoral cell angioma in China: a case report and review. World J Surg Oncol 2011;9:168. 
  46. Wang Z, Zhang L, Zhang B, Mu D, Cui K, Li S. Hemangioendothelioma arising from the spleen: a case report and literature review. Oncol Lett 2015;9:209-212.  https://doi.org/10.3892/ol.2014.2693
  47. Wheelwright M, Spartz EJ, Skubitz K, Yousaf H, Murugan P, Harmon JV. Primary angiosarcoma of the spleen, a rare indication for splenectomy: a case report. Int J Surg Case Rep 2021;82:105929.