한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제51권3호
  • /
  • Pages.317-324
  • /
  • 2023
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Deciphering Key Genes of Proliferative and Secretory Phase Using Integrated Transcriptomics and Network Analysis

  • Payal Gupta (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Shriya Dube (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Payal Priyadarshini (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Shanvi Singh (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Anasuya Pravallika R (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Vijay Lakshmi Srivastava (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Abhishek Sengupta (Amity Institute of Biotechnology, Amity University Uttar Pradesh) ;
  • Priyanka Narad (Amity Institute of Biotechnology, Amity University Uttar Pradesh)
  • 투고 : 2023.04.26
  • 심사 : 2023.06.28
  • 발행 : 2023.09.28
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초록

Endometrium receptivity is a complex mechanism of intricate pathways that lead to the shift from the proliferative to the secretory phase. Our goal was to identify high-ranking differentially expressed genes and study the pathways associated with the phenomenon. Raw data were retrieved from six GEO datasets and 705 DEGs were identified through robust ranking aggregation after the integration of five datasets. 20 key genes were identified that were further re-validated in an additional dataset. Supporting evidence through the experimental references confirms them as major biomarkers of the shift from the proliferative to the secretory phase.

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과제정보

We would like to acknowledge Dr. Ashok K. Chauhan, Founder, and President, Amity University, Uttar Pradesh for providing us the opportunity to conduct research. We would also like to thank Centre for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Amity University for providing us with necessary resources.

참고문헌

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