Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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Age-Related Loss of Skeletal Muscle and Associated Risk Factors in Middle-Aged Men: A Comprehensive Study

  • Received : 2023.04.21
  • Accepted : 2023.05.02
  • Published : 2023.05.31
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Abstract

PURPOSE: This study examined the specific clinical risk factors in middle-aged men with age-related loss of skeletal muscle mass (ALSMM). METHODS: The present research analyzed the data from a cross-sectional study of 1,564 community-dwelling participants aged between 40 to 49 years old. The participants were screened for ALSMM. The study examined various risk factors, including age, height, weight, body mass index, waist circumference, skeletal muscle mass index, smoking and drinking status, systolic and diastolic blood pressure, fasting glucose levels, and triglyceride and cholesterol levels. RESULTS: The risk factors of ALSMM were height, body mass index, waist circumference, skeletal muscle mass index, systolic blood pressure, diastolic blood pressure, drinking status, fasting glucose, and triglyceride levels (p < .05). The weight, triglyceride, and smoking status variables were non-significant (p > .05). CONCLUSION: The risk factors for ALSMM among community-dwelling adults were determined. These results are expected to contribute to the existing literature on ALSMM and provide potential risk factors associated with the development of ALSMM in middle-aged males.

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References

  1. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997;127:990S-1S.  https://doi.org/10.1093/jn/127.5.990S
  2. Critchley MJTL. The neurology of old age. 1931;217(5621):1119-27.  https://doi.org/10.1016/S0140-6736(00)90705-0
  3. Kulik CT, Ryan S, Harper S, et al. Aging populations and management. Academy of Management Briarcliff Manor, NY. 2014. pp.929-35. 
  4. Brown JC, Harhay MO, Harhay MN. Sarcopenia and mortality among a population-based sample of community-dwelling older adults. J Cachexia Sarcopenia Muscle. 2016;7(3):290-8.  https://doi.org/10.1002/jcsm.12073
  5. Liu X, Hao Q, Yue J, et al. Sarcopenia, obesity and sarcopenia obesity in comparison: prevalence, metabolic profile, and key differences: results from WCHAT study. J Nutr Health Aging. 2020;24(4):429-37.  https://doi.org/10.1007/s12603-020-1332-5
  6. Hai S, Wang H, Cao L, et al. Association between sarcopenia with lifestyle and family function among community-dwelling Chinese aged 60 years and older. BMC Geriatr. 2017;17(1):187. 
  7. Chan R, Leung J, Woo J. A prospective cohort study to examine the association between dietary patterns and sarcopenia in chinese community-dwelling older people in Hong kong. J Am Med Dir Assoc. 2016;17(4):336-42.  https://doi.org/10.1016/j.jamda.2015.12.004
  8. Nishiguchi S, Yamada M, Fukutani N, et al. Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults. J Am Med Dir Assoc. 2015;16(2):120-4.  https://doi.org/10.1016/j.jamda.2014.07.010
  9. Kang SY, Lim GE, Kim YK, et al. Association between sarcopenic obesity and metabolic syndrome in postmenopausal women: a cross-sectional study based on the korean national health and nutritional examination surveys from 2008 to 2011. J Bone Metab. 2017;24(1):9-14.  https://doi.org/10.11005/jbm.2017.24.1.9
  10. Velazquez-Alva MC, Irigoyen Camacho ME, Lazarevich I, et al. Comparison of the prevalence of sarcopenia using skeletal muscle mass index and calf circumference applying the European consensus definition in elderly Mexican women. Geriatr Gerontol Int. 2017;17(1):161-70.  https://doi.org/10.1111/ggi.12652
  11. Lee HN KB. Convergence factors affecting sarcopenia in middle-aged and older women in korea: a cross sectional study by using 5th KNHANES. Journ Kor Converg Soc. 2020;11(11):405-16. 
  12. Silva TLD, Mulder AP. Sarcopenia and poor muscle quality associated with severe obesity in young adults and middle-aged adults. Clin Nutr ESPEN. 2021;45:299-305.  https://doi.org/10.1016/j.clnesp.2021.07.031
  13. Stenholm S, Harris TB, Rantanen T, et al. Sarcopenic obesity-definition, etiology and consequences. Curr Opin Clin Nutr Metab Care. 2008;11(6):693. 
  14. Hashemi R, Shafiee G, Motlagh AD, et al. Sarcopenia and its associated factors in Iranian older individuals: Results of SARIR study. Arch Gerontol Geriatr. 2016;66:18-22.  https://doi.org/10.1016/j.archger.2016.04.016
  15. Santos VRd, Araujo MYC, Cardoso MR, et al. Association of insufficient physical activity with sarcopenia and sarcopenic obesity in individuals aged 50 years or more. Revista de Nutricao. 2017;30:175-84.  https://doi.org/10.1590/1678-98652017000200003
  16. Huschtscha Z, Parr A, Porter J, et al. sarcopenic characteristics of active older adults: a cross-sectional exploration. Sports Med Open. 2021;7(1):32. 
  17. Hwang J, Park S. Gender-specific risk factors and prevalence for sarcopenia among community-ewelling young-old adults. Intern J of Environ Res and Pub Health. 2022;19(12):7232. 
  18. Hwang J, Park S. Sex differences of sarcopenia in an elderly asian population: the prevalence and risk factors. Intern J of Environ Res and Pub Health. 2022;19(19):11980. 
  19. Hwang J, Park S. Gender-specific prevalence and risk Factors of sarcopenic obesity in the korean elderly population: A nationwide cross-sectional study. Intern J of Environ Res and Pub Health. 2023;20(2):1140. 
  20. Lexell J, Downham D, Sjostrom M. Distribution of different fibre types in human skeletal muscles. Fibre type arrangement in m. vastus lateralis from three groups of healthy men between 15 and 83 years. J Neurol Sci. 1986;72(2-3):211-22.  https://doi.org/10.1016/0022-510X(86)90009-2
  21. Kehayias JJ, Fiatarone MA, Zhuang H, et al. Total body potassium and body fat: relevance to aging. Am J Clin Nutr. 1997;66(4):904-10.  https://doi.org/10.1093/ajcn/66.4.904
  22. Janssen I, Heymsfield SB, Wang ZM, et al. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol (1985). 2000;89(1):81-8.  https://doi.org/10.1152/jappl.2000.89.1.81
  23. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50(5):889-96.  https://doi.org/10.1046/j.1532-5415.2002.50216.x
  24. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31.  https://doi.org/10.1093/ageing/afy169
  25. Studenski SA, Peters KW, Alley DE, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014;69(5):547-58.  https://doi.org/10.1093/gerona/glu010
  26. Sanada K, Miyachi M, Tanimoto M, et al. A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors. Eur J Appl Physiol. 2010;110(1):57-65.  https://doi.org/10.1007/s00421-010-1473-z
  27. Confortin SC, Meneghini V, Ono LM, et al. Anthropometric indicators as a screening tool for sarcopenia in older adults from Florianopolis, Santa Catarina: EpiFloripa Ageing study. Revista De Nutricao-Brazilian Journal of Nutrition. 2017;30(3):287-96.  https://doi.org/10.1590/1678-98652017000300002
  28. Zamboni M, Mazzali G, Fantin F, et al. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18(5):388-95.  https://doi.org/10.1016/j.numecd.2007.10.002
  29. Nair KS. Aging muscle. Am J Clin Nutr. 2005;81(5):953-63.  https://doi.org/10.1093/ajcn/81.5.953
  30. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6(10):772-83.  https://doi.org/10.1038/nri1937
  31. Cesari M, Kritchevsky SB, Baumgartner RN, et al. Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr. 2005;82(2):428-34.  https://doi.org/10.1093/ajcn/82.2.428
  32. Lu CW, Yang KC, Chang HH, et al. Sarcopenic obesity is closely associated with metabolic syndrome. Obes Res Clin Pract. 2013;7(4):e301-7.  https://doi.org/10.1016/j.orcp.2012.02.003
  33. Atkins JL, Whincup PH, Morris RW, et al. Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. J Am Geriatr Soc. 2014;62(2):253-60.  https://doi.org/10.1111/jgs.12652
  34. Androga L, Sharma D, Amodu A, et al. Sarcopenia, obesity, and mortality in US adults with and without chronic kidney disease. Kidney Intern Rep. 2017;2(2):201-11.  https://doi.org/10.1016/j.ekir.2016.10.008
  35. Yin T, Zhang JX, Wang FX, et al. The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults. Diabetes Metab Syndr Obes. 2021;14:1963-73.  https://doi.org/10.2147/DMSO.S308387
  36. Ferreira I, Snijder MB, Twisk JW, et al. Central fat mass versus peripheral fat and lean mass: opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study. J Clin Endocrinol Metab. 2004;89(6):2632-9.  https://doi.org/10.1210/jc.2003-031619
  37. Snijder MB, Henry RM, Visser M, et al. Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. J Hypertens. 2004;22(12):2339-47.  https://doi.org/10.1097/00004872-200412000-00016
  38. Dominguez LJ, Barbagallo M. The cardiometabolic syndrome and sarcopenic obesity in older persons. J Cardiometab Syndr. 2007;2(3):183-9.  https://doi.org/10.1111/j.1559-4564.2007.06673.x
  39. Goswami B, Reang T, Sarkar S, et al. Role of body visceral fat in hypertension and dyslipidemia among the diabetic and nondiabetic ethnic population of Tripura-A comparative study. J Family Med Prim Care. 2020;9(6):2885-90.  https://doi.org/10.4103/jfmpc.jfmpc_187_20
  40. Daskalopoulou C, Wu YT, Pan W, et al. Factors related with sarcopenia and sarcopenic obesity among low- and middle-income settings: the 10/66 DRG study. Sci Rep. 2020;10(1):20453. 
  41. Pang BWJ, Wee SL, Lau LK, et al. Prevalence and associated factors of sarcopenia in singaporean adults-the yishun study. J Am Med Dir Assoc. 2021;22(4):885e1-e10. 
  42. Cui YF, Huang C, Momma H, et al. The longitudinal association between alcohol consumption and muscle strength: A population-based prospective study. Journal of Musculoskeletal & Neuronal Interactions. 2019;19(3):294-9. 
  43. Jyothi MS, Reddy KR, Soontarapa K, et al. Membranes for dehydration of alcohols via pervaporation. J Environ Manage. 2019;242:415-29.  https://doi.org/10.1016/j.jenvman.2019.04.043
  44. Abidin Ozturk ZA, Turkbeyler IH, Demir Z, et al. The effect of blood glucose regulation on sarcopenia parameters in obese and diabetic patients. Turk J Phys Med Rehabil. 2018;64(1):72-9.  https://doi.org/10.5606/tftrd.2018.1068
  45. Du Y, Oh C, No J. Associations between sarcopenia and metabolic risk factors: a systematic review and meta-analysis. J Obes & Metab Synd. 2018;27(3):175-85.  https://doi.org/10.7570/jomes.2018.27.3.175
  46. Cui M, Gang X, Wang G, et al. A cross-sectional study: Associations between sarcopenia and clinical characteristics of patients with type 2 diabetes. Medicine (Baltimore). 2020;99(2):e18708. 
  47. Buscemi C, Ferro Y, Pujia R, et al. Sarcopenia and appendicular muscle mass as predictors of Impaired fasting glucose/type 2 diabetes in elderly women. Nutrients. 2021;13(6):1909. 
  48. Lundsgaard AM, Kiens B. Gender differences in skeletal muscle substrate metabolism - molecular mechanisms and insulin sensitivity. Front Endocrinol (Lausanne). 2014;5:195. 
  49. Buchmann N, Nikolov J, Spira D, et al. Identifying sarcopenia in metabolic syndrome: data from the Berlin aging study II. J Gerontol A Biol Sci Med Sci. 2016;71(2):265-72.  https://doi.org/10.1093/gerona/glv089
  50. Therakomen V, Petchlorlian A, Lakananurak N. Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study. Sci Rep. 2020;10(1):19551. 
  51. Du Y, Wang X, Xie H, et al. Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria. BMC Endocr Disord. 2019;19(1):109. 
  52. Cleasby ME, Jamieson PM, Atherton PJ. Insulin resistance and sarcopenia: mechanistic links between common co-morbidities. J Endocrinol. 2016;229(2):R67-81.  https://doi.org/10.1530/JOE-15-0533
  53. Schrager MA, Metter EJ, Simonsick E, et al. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol (1985). 2007;102(3):919-25. https://doi.org/10.1152/japplphysiol.00627.2006