International Journal of Advanced Culture Technology

The International Promotion Agency of Culture Technology (국제문화기술진흥원)
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Evaluation of Changes in Serum Thyroid Hormone Levels in Patients with Hepatitis B Infection

  • Hyeokjun Yun (Department of Medical Laser Dankook University Graduate School of Medicine) ;
  • Bo Kyeung Jung (Department of Laboratory Medicine, Dankook University College of Medicine) ;
  • In Soo Rheem (Department of Laboratory Medicine, Dankook University College of Medicine) ;
  • Kap No Lee (Bioneer Corporation) ;
  • Jae Kyung Kim (Department of Biomedical Laboratory Science, College of Health & Welfare, Dankook University)
  • Received : 2023.05.06
  • Accepted : 2023.06.10
  • Published : 2023.06.30
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Abstract

Purpose: We aimed to determine the differences in the levels of serum thyroid hormone (free T4 [FT4]) and thyroid stimulating hormone [TSH]) as biomarkers for hepatitis B virus (HBV) infection status, with respect to age and sex. Methods: We retrospectively analyzed serum samples from 200 patients who underwent HBV testing from August 2022 to September 2022. Serum samples were collected from patients suspected of having HBV infection who visited this hospital. Thyroid hormone levels were measured, and patients were grouped according to age and sex. Results: Differences in TSH and FT4 levels in the serum of patients in the HBV-positive and -negative groups were not significant. Among the HBV-positive patients in the younger age group (<60 years), TSH and FT4 levels were 1.78 ± 0.09 µIU/mL (normal: 0.4-5.0 µIU/mL) and 1.24 ± 0.02 ng/mL (normal: 0.8-1.9 ng/mL), respectively, whereas among the HBV-positive patients in the older age group (≥60 years), TSH and FT4 levels were 2.22 ± 0.17 µIU/mL and 1.24 ± 0.07 ng/mL, respectively. Conclusions: The presence of HBV did not markedly affect serum thyroid hormone levels. Our findings shed light on the conflicting evidence on the association between thyroid hormone levels and HBV infection. We, Hyeokjun Yun and Bo Kyeung Jung are co-first authors which made substantial contribution equally to the conception and designed of this work. Jae Kyung Kim, In soo Rheem and Kap No Lee made significant contributions to the acquisition and analysis of the data.

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