Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
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P2X Receptor 3D Structure Prediction Using Homology Modelling

  • Sruthy Sathish (Computational Biology Laboratory, Department of Genetic Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology) ;
  • Thirumurthy Madhavan (Computational Biology Laboratory, Department of Genetic Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology)
  • Received : 2023.02.28
  • Accepted : 2023.03.21
  • Published : 2023.04.10
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Abstract

P2X receptors are ATP-activated ion channels in the plasma membrane. P2X receptors have a role in a diverse range of disorders, making them a valuable therapeutic target. Hence, the present investigation employed homology modelling of the P2X receptor based on the crystal structure of 5SVJ, 6AH4, 5YVE and 5SVL. Twenty models, using both single- and multiple template-based methods, were developed, and the best model was chosen based on the validation result. We observed that a strategy based on multiple templates provided greater accuracy. Future studies involving binding site and docking analysis can make use of the produced structures.

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References

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