과제정보
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01071648). This research was also supported by the "Team Science Award" of Yonsei University College of Medicine (6-2021-0009).
참고문헌
- Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 2021;23:1231-1251 https://doi.org/10.1093/neuonc/noab106
- Louis DN, Wesseling P, Aldape K, Brat DJ, Capper D, Cree IA, et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol 2020;30:844-856 https://doi.org/10.1111/bpa.12832
- Cimino PJ, Holland EC. Targeted copy number analysis outperforms histologic grading in predicting patient survival for WHO grades II/III IDH-mutant astrocytomas. Neuro Oncol 2019;21:819-821 https://doi.org/10.1093/neuonc/noz052
- Aoki K, Nakamura H, Suzuki H, Matsuo K, Kataoka K, Shimamura T, et al. Prognostic relevance of genetic alterations in diffuse lower-grade gliomas. Neuro Oncol 2018;20:66-77 https://doi.org/10.1093/neuonc/nox132
- Olar A, Wani KM, Alfaro-Munoz KD, Heathcock LE, van Thuijl HF, Gilbert MR, et al. IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas. Acta Neuropathol 2015;129:585-596 https://doi.org/10.1007/s00401-015-1398-z
- Reuss DE, Mamatjan Y, Schrimpf D, Capper D, Hovestadt V, Kratz A, et al. IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO. Acta Neuropathol 2015;129:867-873 https://doi.org/10.1007/s00401-015-1438-8
- Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro AM, et al. CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization grades II-III) astrocytomas. J Neuropathol Exp Neurol 2015;74:442-452 https://doi.org/10.1097/NEN.0000000000000188
- Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, et al. Novel, improved grading system(s) for IDH-mutant astrocytic gliomas. Acta Neuropathol 2018;136:153-166 https://doi.org/10.1007/s00401-018-1849-4
- Foulkes WD, Flanders TY, Pollock PM, Hayward NK. The CDKN2A (p16) gene and human cancer. Mol Med 1997;3:5-20 https://doi.org/10.1007/BF03401664
- Sherr CJ. Cancer cell cycles. Science 1996;274:1672-1677 https://doi.org/10.1126/science.274.5293.1672
- Alhejaily A, Day AG, Feilotter HE, Baetz T, Lebrun DP. Inactivation of the CDKN2A tumor-suppressor gene by deletion or methylation is common at diagnosis in follicular lymphoma and associated with poor clinical outcome. Clin Cancer Res 2014;20:1676-1686 https://doi.org/10.1158/1078-0432.CCR-13-2175
- van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, et al. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet 2005;366:985-990 https://doi.org/10.1016/S0140-6736(05)67070-5
- Gutman DA, Cooper LA, Hwang SN, Holder CA, Gao J, Aurora TD, et al. MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set. Radiology 2013;267:560-569 https://doi.org/10.1148/radiol.13120118
- Park YW, Ahn SS, Park CJ, Han K, Kim EH, Kang SG, et al. Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-wildtype lower-grade gliomas. Eur Radiol 2020;30:6475-6484 https://doi.org/10.1007/s00330-020-07090-3
- Choi KS. Deep learning applications in perfusion MRI: recent advances and current challenges. Investig Magn Reson Imaging 2022;26:246-255 https://doi.org/10.13104/imri.2022.26.4.246
- Pak E, Choi SH, Park CK, Kim TM, Park SH, Won JK, et al. Added value of contrast leakage information over the CBV value of DSC perfusion MRI to differentiate between pseudoprogression and true progression after concurrent chemoradiotherapy in glioblastoma patients. Investig Magn Reson Imaging 2022;26:10-19 https://doi.org/10.13104/imri.2022.26.1.10
- Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360:765-773 https://doi.org/10.1056/NEJMoa0808710
- Riemenschneider MJ, Jeuken JW, Wesseling P, Reifenberger G. Molecular diagnostics of gliomas: state of the art. Acta Neuropathol 2010;120:567-584 https://doi.org/10.1007/s00401-010-0736-4
- Boxerman JL, Schmainda KM, Weisskoff RM. Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol 2006;27:859-867
- Cha J, Kim ST, Kim HJ, Kim BJ, Kim YK, Lee JY, et al. Differentiation of tumor progression from pseudoprogression in patients with posttreatment glioblastoma using multiparametric histogram analysis. AJNR Am J Neuroradiol 2014;35:1309-1317 https://doi.org/10.3174/ajnr.A3876
- Maes F, Collignon A, Vandermeulen D, Marchal G, Suetens P. Multimodality image registration by maximization of mutual information. IEEE Trans Med Imaging 1997;16:187-198 https://doi.org/10.1109/42.563664
- Park YW, Han K, Ahn SS, Bae S, Choi YS, Chang JH, et al. Prediction of IDH1-mutation and 1p/19q-codeletion status using preoperative MR imaging phenotypes in lower grade gliomas. AJNR Am J Neuroradiol 2018;39:37-42 https://doi.org/10.3174/ajnr.A5421
- Patel SH, Poisson LM, Brat DJ, Zhou Y, Cooper L, Snuderl M, et al. T2-FLAIR mismatch, an imaging biomarker for IDH and 1p/19q status in lower-grade gliomas: a TCGA/TCIA project. Clin Cancer Res 2017;23:6078-6085 https://doi.org/10.1158/1078-0432.CCR-17-0560
- Kickingereder P, Isensee F, Tursunova I, Petersen J, Neuberger U, Bonekamp D, et al. Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: a multicentre, retrospective study. Lancet Oncol 2019;20:728-740 https://doi.org/10.1016/S1470-2045(19)30098-1
- Isensee F, Jager PF, Kohl SA, Petersen J, Maier-Hein KH. Automated design of deep learning methods for biomedical image segmentation. arXiv [Preprint]. 2019 [cited 2022 November 11]. Available at: https://doi.org/10.48550/arXiv.1904.08128
- Park YW, Eom J, Kim D, Ahn SS, Kim EH, Kang SG, et al. A fully automatic multiparametric radiomics model for differentiation of adult pilocytic astrocytomas from high-grade gliomas. Eur Radiol 2022;32:4500-4509 https://doi.org/10.1007/s00330-022-08575-z
- Choi HJ, Choi SH, You SH, Yoo RE, Kang KM, Yun TJ, et al. MGMT promoter methylation status in initial and recurrent glioblastoma: correlation study with DWI and DSC PWI features. AJNR Am J Neuroradiol 2021;42:853-860 https://doi.org/10.3174/ajnr.A7004
- Chu HH, Choi SH, Ryoo I, Kim SC, Yeom JA, Shin H, et al. Differentiation of true progression from pseudoprogression in glioblastoma treated with radiation therapy and concomitant temozolomide: comparison study of standard and high-b-value diffusion-weighted imaging. Radiology 2013;269:831-840 https://doi.org/10.1148/radiol.13122024
- Yang RR, Shi ZF, Zhang ZY, Chan AK, Aibaidula A, Wang WW, et al. IDH mutant lower grade (WHO grades II/III) astrocytomas can be stratified for risk by CDKN2A, CDK4 and PDGFRA copy number alterations. Brain Pathol 2020;30:541-553 https://doi.org/10.1111/bpa.12801
- Kickingereder P, Bonekamp D, Nowosielski M, Kratz A, Sill M, Burth S, et al. Radiogenomics of glioblastoma: machine learning-based classification of molecular characteristics by using multiparametric and multiregional MR imaging features. Radiology 2016;281:907-918 https://doi.org/10.1148/radiol.2016161382
- Ahn SS, An C, Park YW, Han K, Chang JH, Kim SH, et al. Identification of magnetic resonance imaging features for the prediction of molecular profiles of newly diagnosed glioblastoma. J Neurooncol 2021;154:83-92 https://doi.org/10.1007/s11060-021-03801-y
- Park CJ, Han K, Kim H, Ahn SS, Choi D, Park YW, et al. MRI features may predict molecular features of glioblastoma in isocitrate dehydrogenase wild-type lower-grade gliomas. AJNR Am J Neuroradiol 2021;42:448-456 https://doi.org/10.3174/ajnr.A6983
- Park YW, Park JE, Ahn SS, Kim EH, Kang SG, Chang JH, et al. Magnetic resonance imaging parameters for noninvasive prediction of epidermal growth factor receptor amplification in isocitrate dehydrogenase-wild-type lower-grade gliomas: a multicenter study. Neurosurgery 2021;89:257-265 https://doi.org/10.1093/neuros/nyab136
- Suh CH, Kim HS, Jung SC, Choi CG, Kim SJ. Imaging prediction of isocitrate dehydrogenase (IDH) mutation in patients with glioma: a systemic review and meta-analysis. Eur Radiol 2019;29:745-758 https://doi.org/10.1007/s00330-018-5608-7
- Lu VM, O'Connor KP, Shah AH, Eichberg DG, Luther EM, Komotar RJ, et al. The prognostic significance of CDKN2A homozygous deletion in IDH-mutant lower-grade glioma and glioblastoma: a systematic review of the contemporary literature. J Neurooncol 2020;148:221-229 https://doi.org/10.1007/s11060-020-03528-2
- Aibaidula A, Chan AK, Shi Z, Li Y, Zhang R, Yang R, et al. Adult IDH wild-type lower-grade gliomas should be further stratified. Neuro Oncol 2017;19:1327-1337 https://doi.org/10.1093/neuonc/nox078
- Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, et al. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med 2015;372:2481-2498 https://doi.org/10.1056/NEJMoa1402121
- Ono Y, Tamiya T, Ichikawa T, Kunishio K, Matsumoto K, Furuta T, et al. Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices. J Neuropathol Exp Neurol 1996;55:1026-1031 https://doi.org/10.1097/00005072-199655100-00002
- Labuhn M, Jones G, Speel EJ, Maier D, Zweifel C, Gratzl O, et al. Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas. Oncogene 2001;20:1103-1109 https://doi.org/10.1038/sj.onc.1204197
- Zerrouqi A, Pyrzynska B, Febbraio M, Brat DJ, Van Meir EG. P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3. J Clin Invest 2012;122:1283-1295 https://doi.org/10.1172/JCI38596
- Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002;29(6 Suppl 16):15-18 https://doi.org/10.1053/sonc.2002.37263
- Patel SH, Batchala PP, Mrachek EKS, Lopes MS, Schiff D, Fadul CE, et al. MRI and CT identify isocitrate dehydrogenase (IDH)-mutant lower-grade gliomas misclassified to 1p/19q codeletion status with fluorescence in situ hybridization. Radiology 2020;294:160-167 https://doi.org/10.1148/radiol.2019191140
- Kerkhof J, Schenkel LC, Reilly J, McRobbie S, Aref-Eshghi E, Stuart A, et al. Clinical validation of copy number variant detection from targeted next-generation sequencing panels. J Mol Diagn 2017;19:905-920 https://doi.org/10.1016/j.jmoldx.2017.07.004
- Talevich E, Shain AH, Botton T, Bastian BC. CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing. PLoS Comput Biol 2016;12:e1004873
- Kim M, Kim S, Park YW, Han K, Ahn SS, Moon JH, et al. Sex as a prognostic factor in adult-type diffuse gliomas: an integrated clinical and molecular analysis according to the 2021 WHO classification. J Neurooncol 2022;159:695-703 https://doi.org/10.1007/s11060-022-04114-4