대한영양사협회학술지 (Journal of the Korean Dietetic Association)

  • 제29권2호
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  • Pages.100-113
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  • 2023
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  • 1225-9861(pISSN)
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  • 2383-966X(eISSN)
대한영양사협회 (The Korean Dietetic Association)
권호 표지
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여성 노인 알코올성 간질환 환자를 대상으로 한 환자균형식 두유 섭취 전과 후의 영양상태 및 혈액 인자 비교

Comparison of Nutritional Status and Blood Factors Before and After Consumption of Balanced Soymilk in Elderly Female Patients with Alcoholic Liver Disease

  • 신경옥 (삼육대학교 식품영양학과) ;
  • 황효정 (삼육대학교 식품영양학과) ;
  • 정재일 (삼육서울병원 소화기내과) ;
  • 전광진 (삼육식품) ;
  • 송중화 (삼육식품) ;
  • 문대균 (삼육식품)
  • Kyung-Ok Shin (Dept. of Food and Nutrition, Sahmyook University) ;
  • Hyo-Jeong Hwang (Dept. of Food and Nutrition, Sahmyook University) ;
  • Jae-Il Chung (Dept. of Gastroenterology, Sahmyook Medical Center) ;
  • Kwang-Jin Chon (Sahmyook Food) ;
  • Chung-Hwa Song (Sahmyook Food) ;
  • Dae-Gyun Moon (Sahmyook Food)
  • 투고 : 2023.04.18
  • 심사 : 2023.05.25
  • 발행 : 2023.05.02
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초록

This was a clinical trial study to aid the recovery of elderly female alcoholic liver disease patients by providing a balanced nutritional supplement comprising soymilk. All patients gave their consent before enrolling. The average demographics of the subjects were age 81.57 years, height 150.43 cm, weight 52.67 kg, and body mass index 24.15 kg/m2. An increase in the daily consumption of fruits and fruit juice was observed after the patients had started taking the balanced meal as compared to before. Intakes of vitamin A, vitamin C, vitamin E, and cholesterol decreased after consuming soymilk, whereas vitamin B12, niacin, folic acid, and dietary fiber significantly increased (P<0.05). Blood cholesterol and BUN levels showed a decreasing tendency. Our results indicate that consuming soymilk in a balanced diet for female patients afflicted with alcoholic liver disease helps improve their nutritional status by increasing the nutrients lacking in the body.

키워드

과제정보

This research was supported by Sahmyook Food, and a clinical trial was conducted at Sahmyook Medical Center.

참고문헌

  1. Akanji AO, Hockaday TD (1990): Acetate tolerance and the kinetics of acetate utilization in diabetic and nondiabetic subjects. Am J Clin Nutr 51(1):112-118 https://doi.org/10.1093/ajcn/51.1.112
  2. Anthony MS (2000): Soy and cardiovascular disease: cholesterol lowering and beyond. J Nutr 130(3):662S-663S https://doi.org/10.1093/jn/130.3.662S
  3. Chang NS, Kim JM, Kim EJ (1999): Nutritional state and dietary behavior of the free-living elderly women. Korean J Diet Clut 14(2):155-165
  4. Cho WK, Choi JH (2007): Effect of pyroligneous liquor on lipid metabolism in serum of CD rats. Korean J Nutr 40(1):24-30
  5. Cho YH, Kim JS, Kim SS, Jung JK, Yoon SJ, Kim HY, Bae YK (2017): Association between alcohol drinking and the ratio of aspartate aminotransferase to alanine aminotransferase in Korean adult male. Korean J Health Promot 17(2):64-70 https://doi.org/10.15384/kjhp.2017.17.2.64
  6. Choi HT, Kim ES, Ham SS, Park SY, Chung HY (2008): Effects of complex food ingredient composed of garlic and fermented soybean hypocotyl on the serum lipid profiles of the rats fed high-fat diet. Korean J Food Sci Technol 40(2): 215-219
  7. Choi KS, Kim YH, Shin KO (2016): Effect of mulberry extract on the lipid profile and liver function in mice fed a high fat diet. Korean J Food Nutr 29(3):411-419 https://doi.org/10.9799/ksfan.2016.29.3.411
  8. Chyun JH, Shin MW (1988): Nutritional status in healthy elderly Koreans from urban households. Korean J Nutr 21(1): 12-22
  9. Freinkel N, Singer DL, Arky RA, Bleicher SJ, Anderson JB, Silbert CK (1963): Alcohol hypoglycemia. I. carbohydrate metabolism of patients with clinical alcohol hypoglycemia and the experimental reproduction of the syndrome with pure ethanol. J Clin Invest 42(7):1112-1133 https://doi.org/10.1172/JCI104797
  10. Hong SM, Choi SY (1996): A study on meal management and nutrient intake of the elderly. J Korean Soc Food Sci Nutr 25(6):1055-1061
  11. Jang SY, Sin KA, Park NY, Kim DH, Kim MJ, Kim JH, Jeong YJ (2008): Changes of quality characteristics of lowmolecular soymilk according to hydrolysis time. J Korean Soc Food Sci Nutr 37(10):1287-1293
  12. Jeon JS, Jang YH, Choung MG (2022): Contents of isoflavone in a prime core set of Korean soybean germplasms. J Korean Soc Food Sci Nutr 51(10):1109-1117 https://doi.org/10.3746/jkfn.2022.51.10.1109
  13. Jun DW (2011): Nutrition and chronic liver disease. Hanyang Med Rev 31(4):228-234 https://doi.org/10.7599/hmr.2011.31.4.228
  14. Jung SH, Lee SH, Ko KS (2016): Effects of oleanolic acid and hederagenin on acute alcohol-induced hepatotoxicity in mice. J Korean Soc Food Sci Nutr 45(3):307-312 https://doi.org/10.3746/jkfn.2016.45.3.307
  15. Jung WY (2022): Alcohol drinking, smoking, and diabetes. J Korean Diabetes 23(3):192-200 https://doi.org/10.4093/jkd.2022.23.3.192
  16. Kim AN, Lim HS (2014): Effects of nutrition education on nutrition-related knowledge, dietary habits, and nutrient intakes of alcoholic patients. J Nutr Health 47(4):277-286 https://doi.org/10.4163/jnh.2014.47.4.277
  17. Kim DK, Choi EJ, Kim CH, Kim YB, Kim EM, Kum JS, Park JD (2014): Physicochemical properties of rice grain-added soymilk. J Korean Soc Food Sci Nutr 43(8):1278-1282 https://doi.org/10.3746/jkfn.2014.43.8.1278
  18. Kim DM, Kim KH (2019): Food and nutrient intake status of Korean elderly by perceived anxiety and depressive condition: data from Korean National Health and Nutrition Examination Survey 2013-2015. J Nutr Health 52(1):58-72 https://doi.org/10.4163/jnh.2019.52.1.58
  19. Kim HJ, Yang HJ, Kim MH, Ryu GH, Jung JY (2009): Effect of saengmaec-san on the level of blood glucose and serum components in streptozocin-induced diabetic rats. J Korean Soc Food Sci Nutr 38(9):1179-1186
  20. Kim HS, Kang DS (2022): Effects of mung bean on serum bun and enzyme activities in hyperlipidemic rats induced by high cholesterol diet. J Korean Appl Sci Technol 39(6):760-768
  21. Kim JS (2012): Management of drinking patients in primary care. Korean J Fam Pract 2(4):280-288
  22. Kim JY, Kwon SH, Hwang BS, Jang M, Kang HJ, Kim GC, Hwang IG (2021): Changes in isoflavone composition of soybean according to processing methods. J Korean Soc Food Sci Nutr 50(4):403-409 https://doi.org/10.3746/jkfn.2021.50.4.403
  23. Kim WY, Cho MS, Lee HS (2003): Development and validation of mini dietary assessment index for Koreans. Korean J Nutr 36(1):83-92
  24. Koo BK, Chung JM, Lee HS (1997): A study on the alcohol consumption and nutrient intake in patients with alcoholic liver disease. Korean J Nutr 30(1):48-60
  25. Koo BK, Chung JM, Lee HS (1998): Biochemical evaluation of nutritional status of vitamins and minerals in patients with alcoholic liver Disease. J Korean Soc Food Sci Nutr 27(6): 1244-1252
  26. Korea Disease Control and Prevention Agency (2022). Korea Health Statistics 2021: Korea National Health and Nutrition Examination Survey (KNHANES VIII-3). Available from: http://knhanes.kdca.go.kr/. Accessed February 16, 2023
  27. Kwon JS, Lee SH, Lee KM, Lee Y (2016): Study on energy and nutrient intake and food preference of the elderly in care facilities. Korean J Community Nutr 21(2):200-217 https://doi.org/10.5720/kjcn.2016.21.2.200
  28. Lee EH, Chyun JH (2009): Effects of chongkukjang intake on lipid metabolism and liver function in alcoholic fatty liver rats. J Korean Soc Food Sci Nutr 38(11):1506-1515 https://doi.org/10.3746/jkfn.2009.38.11.1506
  29. Lee JH (2007): Managements of the alcoholic liver diseases. Korean J Med 72(1):113-115
  30. Lee LS, Jung KH, Choi UK, Hong HD, Kim YC (2013a): Ginsenosides composition and antioxidant activities of fermented ginseng soymilk. J Korean Soc Food Sci Nutr 42(10):1533-1538 https://doi.org/10.3746/jkfn.2013.42.10.1533
  31. Lee SH, Jang DH, Choi HJ, Park YS (2013b): Optimization of soymilk fermentation by the protease-producing Lactobacillus paracasei. Korean J Food Sci Technol 45(5):571-577 https://doi.org/10.9721/KJFST.2013.45.5.571
  32. Lee YH, Lee KJ (2003): A study on the nutritional knowledge, nutrients intake and dietary behavior of old people in Incheon area. J East Asian Soc Diet Life 13(1):9-18
  33. Lieber CS (1993): Aetiology and pathogenesis of alcoholic liver disease. Baillieres Clin Gastroenterol 7(3):581-608 https://doi.org/10.1016/0950-3528(93)90003-B
  34. Lieber CS (2003): Relationships between nutrition, alcohol use, and liver disease. Alcohol Res Health 27(3):220-231
  35. Lieber CS, DeCarli LM (1991): Hepatotoxicity of ethanol. J Hepatol 12(3):394-401 https://doi.org/10.1016/0168-8278(91)90846-4
  36. McDonough KH (2003): Antioxidant nutrients and alcohol. Toxicology 189(1-2):89-97 https://doi.org/10.1016/S0300-483X(03)00155-0
  37. Mendenhall C, Bongiovanni G, Goldberg S, Miller B, Moore J, Rouster S, Schneider D, Tamburro C, Tosch T, Weesner R (1985): VA cooperative study on alcoholic hepatitis. III: changes in protein-calorie malnutrition associated with 30 days of hospitalization with and without enteral nutritional therapy. JPEN J Parenter Enteral Nutr 9(5):590-596 https://doi.org/10.1177/0148607185009005590
  38. Mendenhall C, Roselle GA, Gartside P, Moritz T (1995): Relationship of protein calorie malnutrition to alcoholic liver disease: a reexamination of data from two Veterans Administration Cooperative Studies. Alcohol Clin Exp Res 19(3):635-641 https://doi.org/10.1111/j.1530-0277.1995.tb01560.x
  39. Mendenhall CL, Anderson S, Weesner RE, Goldberg SJ, Crolic KA (1984): Protein-calorie malnutrition associated with alcoholic hepatitis. Veterans Administration Cooperative Study Group on Alcoholic Hepatitis. Am J Med 76(2):211-222 https://doi.org/10.1016/0002-9343(84)90776-9
  40. Mitchell MC, Herlong HF (1986): Alcohol and nutrition: caloric value, bioenergetics, and relationship to liver damage. Annu Rev Nutr 6:457-474 https://doi.org/10.1146/annurev.nu.06.070186.002325
  41. Nakamoto M, Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Imai T, Sakai T, Ando F, Shimokata H (2018): Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women. Eur J Clin Nutr 72(10): 1458-1462 https://doi.org/10.1038/s41430-017-0061-2
  42. National Institute on Alcohol Abuse and Alcoholism (2007). Helping patients who drink too much: a clinician's guide. Updated 2005 edition. Available from: https://books.google.co.kr/books/about/Helping_Patients_who_Drink_Too_Much.html?id=3iSM8DsoUGEC&redir_esc=y. Accessed December 13, 2015
  43. Neville JN, Eagles JA, Samson G, Olson RE (1968): Nutritional status of alcoholics. Am J Clin Nutr 21(11):1329-1340 https://doi.org/10.1093/ajcn/21.11.1329
  44. Noh HS, Kim MJ (2021): Analysis of the effect of blood sugar, calcium, chloride ions, and blood urea nitrogen on skin wrinkles. Asian J Beauty Cosmetol 19(1):77-88 https://doi.org/10.20402/ajbc.2020.0124
  45. Oh DY, Kang DS, Lee YG, Kim HS (2019): Effects of turmeric (Curcuma longa L.) supplementation on blood urea nitrogen and enzyme activities in dyslipidemic rats. J Environ Sci Int 28(5):475-483
  46. Oidovsambuu S, Yun JH, Kang K, Dulamjav B, Tunsag J, Nam EJ, Nho CW (2016): A fruit extract of Paeonia anomala attenuates chronic alcohol-induced liver damage in rats. Nat Prod Sci 22(4):231-237 https://doi.org/10.20307/nps.2016.22.4.231
  47. Omoni AO, Aluko RE (2005): Soybean foods and their benefits: potential mechanisms of action. Nutr Rev 63(8):272-283 https://doi.org/10.1111/j.1753-4887.2005.tb00141.x
  48. Park EJ, Kim JB, Sohn DH, Ko GI (1999): Biotransformation of theophylline in cirrhotic rats induced by carbon tetrachloride or N,N-dimethylnitrosamine. Korean J Clin Pharm 9(1):55-61
  49. Rao TS, Asha MR, Ramesh BN, Rao KS (2008): Understanding nutrition, depression and mental illnesses. Indian J Psychiatry 50(2):77-82 https://doi.org/10.4103/0019-5545.42391
  50. Rhim TJ (2020): Radical scavenging activities and anti-inflammatory effects of soybean extracts. Korean J Community Living Sci 31(2):181-194 https://doi.org/10.7856/kjcls.2020.31.2.181
  51. Rodrigo C, Antezana C, Baraona E (1971): Fat and nitrogen balances in rats with alcohol-induced fatty liver. J Nutr 101(10): 1307-1310 https://doi.org/10.1093/jn/101.10.1307
  52. Seitz HK, Stickel F (2007): Alcoholic liver disease in the elderly. Clin Geriatr Med 23(4):905-921, viii https://doi.org/10.1016/j.cger.2007.06.010
  53. Shafqat M, Jo JH, Moon HH, Choi YI, Shin DH (2022): Alcohol-related liver disease and liver transplantation. Kosin Med J 37(2):107-118 https://doi.org/10.7180/kmj.22.108
  54. Shon DH (1997): Nutritional and bioactive components of soymilk and cow's milk (a review). Korea Soybean Dig 14(1): 66-76
  55. Song DS (2020): Medical treatment of alcoholic liver disease. Korean J Gastroenterol 76(2):65-70 https://doi.org/10.4166/kjg.2020.76.2.65
  56. Sung JH, Choi SJ, Lee SW, Park KH, Moon TW (2004): Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Biosci Biotechnol Biochem 68(5):1051-1058 https://doi.org/10.1271/bbb.68.1051
  57. The Korean Nutrition Society (2020): Dietary reference intakes for Koreans. The Korean Nutrition Society. Seoul. pp.ix-xvii
  58. Torres SJ, McCabe M, Nowson CA (2010): Depression, nutritional risk and eating behaviour in older caregivers. J Nutr Health Aging 14(6):442-448 https://doi.org/10.1007/s12603-010-0041-x
  59. Xiao CW (2008): Health effects of soy protein and isoflavones in humans. J Nutr 138(6):1244S-1249S https://doi.org/10.1093/jn/138.6.1244S
  60. Yang EJ, Bang HM (2008): Nutritional status and health risks of low income elderly women in Gwangju area. Korean J Nutr 41(1):65-76
  61. Yoo LK, Choi SJ, Moon TW, Shim JH (2016): Inhibitory effects of transglycoslyation products of soy isoflavones on cholesterol biosynthesis. J Korean Soc Food Sci Nutr 45(2):293-297 https://doi.org/10.3746/jkfn.2016.45.2.293
  62. Yoon JH, Jun CH, Kim JH, Yoon EL, Kim BS, Song JE, Suk KT, Kim MY, Kang SH (2021): Changing trends in liver cirrhosis etiology and severity in Korea: the increasing impact of alcohol. J Korean Med Sci 36(21):e145
  63. Yoon JY, Cho HK, Lee SR (1993): Effect of phytate on the digestibility and electrophoretic pattern of soy protein isolate. Korean J Food Sci Technol 25(4):360-365