Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
권호 표지
DOI QR코드

DOI QR Code

Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits

  • Man Zhao (Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science, Shandong Agricultural University) ;
  • Tongtong Wang (Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science, Shandong Agricultural University) ;
  • Bin Wang (Animal Husbandry Development and Promotion Center of Mengyin County) ;
  • Chuanhua Liu (Animal Husbandry Development and Promotion Center of Mengyin County) ;
  • Fuchang Li (Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science, Shandong Agricultural University) ;
  • Lei Liu (Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science, Shandong Agricultural University)
  • Received : 2022.07.22
  • Accepted : 2022.10.30
  • Published : 2023.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: Angora rabbits fed a low-protein diet exhibit decreased hair production performance. This study was set out to evaluate the effects of methionine on hair properties and nitrogen metabolism in Angora rabbits fed a low-protein diet and to investigate the gene expression related to hair follicle development to determine the possible molecular mechanism of methionine effects on hair follicle development. Methods: An experiment was conducted to investigate the effects of DL-methionine addition on a low-protein diet on hair development in Angora rabbits. Angora rabbits were divided into 5 groups: fed a normal diet (control), fed a low-protein diet (LP), or fed an LP supplemented with 0.2%, 0.4%, or 0.6% DL-methionine (Met). Results: The results showed that rabbits in the LP group had lower wool yield than the control rabbits, but the addition of 0.4% to 0.6% Met to LP attenuated these effects (p<0.05). Dietary addition of 0.4% to 0.6% Met to LP increased the apparent nitrogen digestibility, nitrogen utilization rate, and feed efficiency (p<0.05). Feeding LP decreased the insulin-like growth factor 1 (IGF1), keratin-associated protein (KAP) 3.1, and KAP 6.1 mRNA levels compared with the control, but the addition of 0.4% Met in LP attenuated these effects (p<0.05). Relative to the LP or control group, dietary addition of 0.4% Met increased versican mRNA levels. Conclusion: In conclusion, the addition of Met to LP could improves wool production performance and feed efficiency and reduce nitrogen emissions in Angora rabbits. Met can promote hair follicle development, which may be associated with IGF1, KAP, and the versican signaling.

Keywords

Acknowledgement

The authors would like to thank the staff of the Angora Rabbit Breeding Base in Mengyin County, Linyi City, China for their help.

References

  1. Rasmussen PV, Borsting CF. Effects of variations in dietary protein levels on hair growth and pelt quality in mink (Mustela vison). Can J Anim Sci 2000;80:633-42. https://doi.org/10.4141/A99-063
  2. Zhang HH, Jiang QK, Sun WL, et al. Effects of different dietary protein levels and DL-methionine supplementation on hair growth and pelt quality in mink (Neovision vision). J Anim Physiol Anim Nutr (Berl) 2013;97:1036-42. https://doi.org/10.1111/jpn.12007
  3. Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr 2006;136(6 Suppl):1636S-40S. https://doi.org/10.1093/jn/136.6.1636S
  4. Zhu Y, Wu Z, Liu H, Liu G, Li F. Methionine promotes the development of hair follicles via the Wnt/β-catenin signalling pathway in Rex rabbits. J Anim Physiol Anim Nutr (Berl) 2020;104;379-84. https://doi.org/10.1111/jpn.13238
  5. Paus R, Cotsarelis G. The biology of hair follicles. N Engl J Med 1999;341:491-7. https://doi.org/10.1056/NEJM199908123410706
  6. Rogers GE. Hair follicle differentiation and regulation. Int J Dev Biol 2004;48(2-3):163-70. https://doi.org/10.1387/ijdb.15272381
  7. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev 2001;81:449-94. https://doi.org/10.1152/physrev.2001.81.1.449
  8. Madaan A, Verma R, Singh AT, Jaggi M. Review of hair follicle dermal papilla cells as in vitro screening model for hair growth. Int J Cosmet Sci 2018;40:429-50. https://doi.org/10.1111/ics.12489
  9. De Blas JC, Mateos GG. Feed formulation. In: The nutrition of the rabbit 2nd Edition. Wallingford Oxon, UK: CABI Publ; 2010, pp. 222-32.
  10. Weinberg WC, Goodman LV, George C, et al. Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growth, and hair quality by dermal cells. J Invest Dermatol 1993;100:229-36. https://doi.org/10.1111/1523-1747.ep12468971
  11. Liu L, Liu H, Fu C, Li C, Li F. Acetate induces anorexia via up-regulating the hypothalamic pro-opiomelanocortin (POMC) gene expression in rabbits. J Anim Feed Sci 2017;26:266-73. https://doi.org/10.22358/jafs/75979/2017
  12. Sahlu T, Fernandez JM. Effect of intraperitoneal administration of lysine and methionine on mohair yield and quality in Angora goats. J Anim Sci 1992;70:3188-93. https://doi.org/10.2527/1992.70103188x
  13. Herrmann S, Lange K, Wortmann FJ. Characteristics of Angora rabbit fibre 2-the influence of the methionine content in feed and of the environmental temperature on fibre and medulla diameter in angora wool. World Rabbit Sci 1996;4:155-8. https://doi.org/10.4995/wrs.1996.288
  14. Dahlman T, Valaja J, Jalava T, Skrede A. Growth and fur characteristics of blue foxes (Alopex lagopus) fed diets with different protein levels and with or without DL-methionine supplementation in the growing-furring period. Can J Anim Sci 2003;83:239-45. https://doi.org/10.4141/A02-078
  15. Schneider MR, Schmidt-Ullrich R, Paus R. The hair follicle as a dynamic miniorgan. Curr Biol 2009;19:R132-R142. https://doi.org/10.1016/j.cub.2008.12.005
  16. Harris PM, McBride BW, Gurnsey MP, Sinclair BR, Lee J. Direct infusion of a variant of insulin-like growth factor-I into the skin of sheep and effects on local blood flow, amino acid utilization and cell replication. J Endocrinol 1993;139:463-72. https://doi.org/10.1677/joe.0.1390463
  17. Zhang YC, Li FC. Effect of dietary methionine on growth performance and insulin-like growth factor-I mRNA expression of growing meat rabbits. J Anim Physiol Anim Nutr (Berl) 2010;94:803-9. https://doi.org/10.1111/j.1439-0396.2009.00975.x
  18. Liu L, Li B, Zhu YL, Wang CY, Li FC. Differential gene expression profiles in foetal skin of Rex rabbits with different wool density. World Rabbit Sci 2016;24:223-31. https://doi.org/10.4995/wrs.2016.2335
  19. Yang BL, Zhang Y, Cao L, Yang BB. Cell adhesion and proliferation mediated through the G1 domain of versican. J Cell Biochem 1999;72:210-20. https://doi.org/10.1002/(SICI)1097-4644(19990201)72:2<210::AID-JCB5>3.0.CO;2-E
  20. Li YH, Zhang K, Ye JX, Lian XH, Yang T. Wnt10b promotes growth of hair follicles via a canonical Wnt signalling pathway. Clin Exp Dermatol 2011;36:534-40. https://doi.org/10.1111/j.1365-2230.2011.04019.x
  21. Zhang H, Nan W, Wang S, et al. Epidermal growth factor promotes proliferation and migration of follicular outer root sheath cells via Wnt/β-catenin signaling. Cell Physiol Biochem 2016;39:360-70. https://doi.org/10.1159/000445630
  22. Guha U, Mecklenburg L, Cowin P, et al. Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling. Am J Pathol 2004;165:729-40. https://doi.org/10.1016/S0002-9440(10)63336-6
  23. Kuwahara A, Sakai H, Xu Y, Itoh Y, Hirabayashi Y, Gotoh Y. Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development. PLoS One 2014;9:e94408. https://doi.org/10.1371/journal.pone.0094408
  24. Qi Y, Li M, Xu L, Chang Z, Shu X, Zhou L. Therapeutic role of human hepatocyte growth factor (HGF) in treating hair loss. Peer J 2016;4:e2624. https://doi.org/10.7717/peerj.2624
  25. Kamiya M, Yamada T, Higuchi M. Influence of dietary crude protein content on fattening performance and nitrogen excretion of Holstein steers. Anim Sci J 2020;91:e13438. https://doi.org/10.1111/asj.13438
  26. Portejoie S, Dourmad JY, Martinez J, Lebretonb Y. Effect of lowering dietary crude protein on nitrogen excretion, manure composition and ammonia emission from fattening pigs. Livest Prod Sci 2004;91:45-55. https://doi.org/10.1016/j.livprodsci.2004.06.013
  27. Abbasi IHR, Abbasi F, Soomro RN, et al. Considering choline as methionine precursor, lipoproteins transporter, hepatic promoter and antioxidant agent in dairy cows. AMB Express 2017;7:214. https://doi.org/10.1186/s13568-017-0513-z
  28. Yesmin S, Uddin ME, Chacrabati R, Al-Mamun M. Effect of methionine supplementation on the growth performance of rabbit. Bang J Anim Sci 2013;42:40-3. https://doi.org/10.3329/bjas.v42i1.15777
  29. Etuk EB, Abaoja ON, Esonu BO. Raw pigeon seed meal in weaner rabbit diet: effect of methionine supplementation. Niger J Anim Prod 2007;34:241-6. https://doi.org/10.51791/njap.v34i2.1195