Molecules and Cells

  • 제46권3호
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  • Pages.131-132
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  • 2023
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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The Multifaceted Roles for NRF2 in Regulating Tumor Development and Progression: An Update

  • 투고 : 2023.03.20
  • 심사 : 2023.03.21
  • 발행 : 2023.03.31
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  1. Anandhan, A., Dodson, M., Shakya, A., Chen, J., Liu, P., Wei, Y., Tan, H., Wang, Q., Jiang, Z., Yang, K., et al. (2023). NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci. Adv. 9, eade9585.
  2. Choi, B.H., Kim, J.M., and Kwak, M.K. (2021). The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance. Arch. Pharm. Res. 44, 263-280. https://doi.org/10.1007/s12272-021-01316-8
  3. Dinkova-Kostova, A.T. and Copple, I.M. (2023). Advances and challenges in therapeutic targeting of NRF2. Trends Pharmacol. Sci. 44, 137-149. https://doi.org/10.1016/j.tips.2022.12.003
  4. Feng, R., Morine, Y., Ikemoto, T., Imura, S., Iwahashi, S., Saito, Y., and Shimada, M. (2018). Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction. Cell Commun. Signal. 16, 54.
  5. Hayashi, M., Kuga, A., Suzuki, M., Panda, H., Kitamura, H., Motohashi, H., and Yamamoto, M. (2020). Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors. Cancer Res. 80, 3331-3344. https://doi.org/10.1158/0008-5472.CAN-19-2888
  6. Hayes, J.D. and Ashford, M.L.J. (2012). Nrf2 orchestrates fuel partitioning for cell proliferation. Cell Metab. 16, 139-141. https://doi.org/10.1016/j.cmet.2012.07.009
  7. Kim, J.Y. and Surh, Y.J. (2009). The role of Nrf2 in cellular innate immune response to inflammatory injury. Toxicol. Res. 25, 159-173. https://doi.org/10.5487/TR.2009.25.4.159
  8. Kumagai, Y., Akiyama, M., and Unoki, T. (2019). Adaptive responses to electrophilic stress and reactive sulfur species as their regulator molecules. Toxicol. Res. 35, 303-310. https://doi.org/10.5487/TR.2019.35.4.303
  9. Mitsuishi, Y., Motohashi, H., and Yamamoto, M. (2012). The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Front. Oncol. 2, 200.
  10. Satoh, H., Moriguchi, T., Taguchi, K., Takai, J., Maher, J.M., Suzuki, T., Winnard, P.T., Jr., Raman, V., Ebina, M., Nukiwa, T., et al. (2010). Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. Carcinogenesis 31, 1833-1843. https://doi.org/10.1093/carcin/bgq105
  11. de la Vega, M.R., Chapman, E., and Zhang, D.D. (2018). NRF2 and the hallmarks of cancer. Cancer Cell 34, 21-43. https://doi.org/10.1016/j.ccell.2018.03.022
  12. Yamamoto, M., Kensler, T.W., and Motohashi, H. (2018). The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol. Rev. 98, 1169-1203. https://doi.org/10.1152/physrev.00023.2017