DOI QR코드

DOI QR Code

폐의 좁쌀 결절로 발현된 림프종 사례: 증례 보고

Diffuse Large B-Cell Lymphoma Manifesting as Miliary Nodules in the Lung: A Case Report

  • 나효주 (충남대학교 의과대학 충남대학교병원 영상의학과) ;
  • 권혜영 (충남대학교 의과대학 충남대학교병원 영상의학과) ;
  • 김성수 (충남대학교 의과대학 충남대학교병원 영상의학과) ;
  • 박형규 (충남대학교 의과대학 충남대학교병원 병리과)
  • Hyo Ju Na (Department of Radiology Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Hyeyoung Kwon (Department of Radiology Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Song Soo Kim (Department of Radiology Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Hyung Kyu Park (Department of Pathology, Chungnam National University Hospital, Chungnam National University School of Medicine)
  • 투고 : 2023.07.18
  • 심사 : 2023.10.31
  • 발행 : 2023.11.01

초록

악성 림프종은 흉부 CT에서 결절, 종양, 폐 경화, 간유리음영 등 다양한 폐질환으로 나타날 수 있으며 이러한 폐 병변은 다른 질환의 양상과 유사하여 진단에 어려움을 줄 수 있다. 본 증례는 호흡곤란과 발열을 주 증상으로 하는 67세 남성 환자로 해당 환자의 흉부 CT상 크기가 작은 다발성 결절이 양측에 미만성으로 나타나 혈행성 전이, 좁쌀 결핵 또는 진균 감염을 의심해 볼 수 있었다. 그러나 추가적으로 시행한 혈액 검사, 영상 검사 및 조직 생검 결과 폐를 침범한 미만성 큰 B세포 림프종이 진단되었다. 저자들은 폐의 좁쌀 결절로 발현한 매우 드문 림프종을 보고한다. 환자의 적절한 진단을 위해서는 환자의 병력, 신체 진찰, 혈액 검사 및 영상 소견의 포괄적인 평가가 필요하다.

Malignant lymphoma has various pulmonary manifestations on chest CT, including nodules, masses, areas of consolidation, and ground-glass opacity. These presentations can pose a diagnostic challenge, as they mimic other disease patterns. Herein, we report a case of diffuse large B-cell lymphoma (DLBCL) manifesting as miliary nodules in a 67-year-old male initially presenting with dyspnea and fever. Radiologic findings included diffuse, bilateral, multiple tiny nodules consistent with metastasis, miliary tuberculosis, and fungal infection. However, further investigations, including laboratory tests, imaging, and biopsies, led to the diagnosis of DLBCL involving the lungs. Herein we reported a rare case of lymphoma involvement of the lung presenting as miliary nodules. Accurate diagnosis relies on a comprehensive evaluation of the clinical history, physical features, laboratory test results, and imaging findings.

키워드

참고문헌

  1. Angirish B, Sanghavi P, Jankharia B. Pulmonary manifestations of lymphoma: a pictorial essay. Lung India 2020;37:263-267
  2. Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, et al. Primary pulmonary lymphoid lesions: radiologic and pathologic findings. Radiographics 2016;36:53-70
  3. Shinoda K, Taki H, Tsuda T, Hayashi R, Nomoto K, Tobe K. Primary pulmonary lymphoma presenting with multiple lung nodules. Am J Respir Crit Care Med 2014;190:e30-e31
  4. Gao X, Yan P. Primary pulmonary lymphoma presenting as nodules and masses: a case report and literature review. Monaldi Arch Chest Dis 2021;91:1259
  5. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69:7-34
  6. Hare SS, Souza CA, Bain G, Seely JM, Frcpc, Gomes MM, et al. The radiological spectrum of pulmonary lymphoproliferative disease. Br J Radiol 2012;85:848-864
  7. Andreu J, Mauleon S, Pallisa E, Majo J, Martinez-Rodriguez M, Caceres J. Miliary lung disease revisited. Curr Probl Diagn Radiol 2002;31:189-197
  8. Kim J, Dabiri B, Hammer MM. Micronodular lung disease on high-resolution CT: patterns and differential diagnosis. Clin Radiol 2021;76:399-406
  9. Yagyu K, Kobayashi M, Ueda T, Uenishi R, Nakatsuji Y, Matsushita H. Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings. Respir Med Case Rep 2020;31:101239
  10. Miyake S, Yoshizawa Y, Ohkouchi Y, Kurashima A, Hebisawa A. Non-Hodgkin's lymphoma with pulmonary infiltrates mimicking miliary tuberculosis. Intern Med 1997;36:420-423