Fisheries and Aquatic Sciences

한국수산과학회 (The Korean Society of Fisheries and Aquatic Science)
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Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

  • Tae-Hee Kim (Research Center for Marine-Integrated Bionics Technology, Pukyong National University) ;
  • Se-Chang Kim (Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University) ;
  • Won-Kyo Jung (Research Center for Marine-Integrated Bionics Technology, Pukyong National University)
  • 투고 : 2022.08.19
  • 심사 : 2022.11.05
  • 발행 : 2023.01.30
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초록

Marine bioactive substances (MBS), such as phlorotannins, collagens, peptides, sterols, and polysaccharides, are increasing attention as therapeutic agents for several diseases due to their pharmacological effects. Previous studies have demonstrated the biological activities of MBS including antibacterial, anticoagulant, antidiabetic, antimicrobial, anti-inflammatory activities. Among numerous human diseases, periodontitis is one of the high-prevalence inflammatory diseases in the world. To treat periodontitis, several surgeries (bone grafting, flap surgery, and soft tissue graft) are usually used. However, the surgery for patients with chronic periodontitis induces several side effects, including additional inflammatory responses at the operated site, chronic wound healing, and secondary surgery. Therefore, this review assessed the most recent trends in MBS using Google Scholar, PubMed, and Web of Science search engines to develop marine-derived therapeutic agents for periodontitis. Further, we summarized the current applications and therapeutic potential of MBS to serve as a reference for developing novel technologies applied to MBS against periodontitis treatment.

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과제정보

This research was financially supported by the Research Grant of Pukyong National University (2021).

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