Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
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The use of animal models in rheumatoid arthritis research

  • Jin-Sun Kong (Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea) ;
  • Gi Heon Jeong (Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea) ;
  • Seung-Ah Yoo (Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea)
  • 투고 : 2022.10.18
  • 심사 : 2022.11.04
  • 발행 : 2023.01.31
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초록

The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of human RA. Spontaneous and induced animal models of RA primarily reflect inflammatory aspects of the disease. Among various induced animal models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) models are widely used to study the pathogenesis of RA. Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of RA, including CIA and CAIA. In addition, we describe a SCID mouse coimplantation model that can measure the long-distance migration of human RA synoviocytes and cartilage destruction induced by these cells.

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과제정보

This work was supported by grants from the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (2019R1A2C2010897).

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