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  • 제23권1호
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  • Pages.11.1-11.11
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  • 2023
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Roles of Virtual Memory T Cells in Diseases

  • Joon Seok (Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine) ;
  • Sung-Dong Cho (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ;
  • Seong Jun Seo (Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine) ;
  • Su-Hyung Park (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)
  • 투고 : 2023.01.18
  • 심사 : 2023.02.09
  • 발행 : 2023.02.28
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초록

Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a "memory-like" T-cell population, termed virtual memory T (TVM) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, TVM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of TVM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.

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과제정보

This work was supported by the 2020 Joint Research Project of Institutes of Science and Technology (to Park SH), as well as by a Global PhD Fellowship from the National Research Foundation of Korea (NRF-2019H1A2A1076361 to Seok J).

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