Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Potentially Unnecessary Gastrointestinal Drug Use in Patients with Acute Cystitis

외래 급성 방광염 환자에서 잠재적으로 불필요한 위장약 사용

  • Taeyeon Kim (College of Pharmacy, Pusan National University) ;
  • Song Hyeon Jeon (Department of Pharmacy, Dong-A University Hospital) ;
  • Nam Kyung Je (College of Pharmacy, Pusan National University)
  • 김태연 (부산대학교 약학대학, 약물사용연구실) ;
  • 전송현 (동아대학교병원 약제부) ;
  • 제남경 (부산대학교 약학대학, 약물사용연구실)
  • Received : 2022.11.09
  • Accepted : 2023.01.30
  • Published : 2023.03.31
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Abstract

Background: Gastrointestinal (GI) drugs are often co-prescribed with other medications to prevent GI complications. This study aimed to evaluate the prescribing pattern of potentially unnecessary GI drugs in patients with acute cystitis who were prescribed oral antibiotics and investigate the influencing factors affecting this. Methods: We identified female patients ≥20 years with acute cystitis who visited the outpatient clinic and were prescribed oral antibiotics between July and December by analyzing Health Insurance Review and Assessment Service (HIRA)-National Patients Sample (NPS)-2019 data. Patients with no prior history of GI disorders within 180 days prior to acute cystitis, excluding or including the date of diagnosis of acute cystitis, were selected (Group A and B). Multiple logistic regression analysis was performed to estimate the factors affecting the prescription of potentially unnecessary GI drugs. Results: A total of 1,544 in Group A and 552 patients in Group B were included for the final analysis. Potentially unnecessary GI drugs were prescribed in 1,176 patients in Group A (76.2%) and 231 patients in Group B (41.8%). Third generation cephalosporines and sulfonamides showed the lower odds ratio for prescribing GI drugs than penicillins. Prescribers from Urology clinics showed more than twice odds ratio for the prescription of GI drugs compared to prescribers from internal medicine clinics. Conclusion: The results of this study showed that potentially unnecessary GI drug prescriptions for patients with acute cystitis were high in South Korea. The positive risk factors affecting the prescription of unnecessary GIs were not patient-related factor but healthcare facility and prescriber-related factors.

Keywords

Acknowledgement

이 연구는 건강보험심사평가원의 표본자료(HIRA-NPS-2019, S20211126692) 활용하였으며, 연구의 결과는 보건복지부 및 건강보험심사평가원과 무관함. 이 과제는 부산대학교 기본연구지원사업(2년)에 의하여 연구되었음.

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