DOI QR코드

DOI QR Code

A case of Candida albicans-induced fungal keratitis in a Chihuahua dog - with a focus on optical coherence tomographic features

  • 투고 : 2022.05.09
  • 심사 : 2023.02.17
  • 발행 : 2023.03.31

초록

A 4-year-old Chihuahua dog was referred for bilateral corneal ulcers. Slightly raised white fluorescein-positive plaque-like corneal lesions in both eyes appeared as intense hyperreflective areas with posterior shadowing on optical coherence tomography (OCT). Based on corneal cytology and culture, Candida albicans-induced fungal keratitis was diagnosed. Despite treatment, on OCT, endothelial plaques, increased stromal infiltration thickness, vertical shapes of the ulcer edge, and necrotic stromal space were judged to be aggravation of the disease, and surgery was performed. Conjunctival grafting surgery with topical 1% voriconazole effectively resolved fungal keratitis. OCT can provide detailed and objective information related to the disease prognosis.

키워드

참고문헌

  1. Scott EM, Carter RT. Canine keratomycosis in 11 dogs: a case series (2000-2011). J Am Anim Hosp Assoc. 2014;50(2):112-118. https://doi.org/10.5326/JAAHA-MS-6012
  2. Ledbetter EC, Norman ML, Starr JK. In vivo confocal microscopy for the detection of canine fungal keratitis and monitoring of therapeutic response. Vet Ophthalmol. 2016;19(3):220-229. https://doi.org/10.1111/vop.12287
  3. Nevile JC, Hurn SD, Turner AG. Keratomycosis in five dogs. Vet Ophthalmol. 2016;19(5):432-438. https://doi.org/10.1111/vop.12313
  4. Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW. The global incidence and diagnosis of fungal keratitis. Lancet Infect Dis. 2021;21(3):e49-e57. https://doi.org/10.1016/S1473-3099(20)30448-5
  5. Famose F. Assessment of the use of spectral domain optical coherence tomography (SD-OCT) for evaluation of the healthy and pathological cornea in dogs and cats. Vet Ophthalmol. 2014;17(1):12-22. https://doi.org/10.1111/vop.12028
  6. Ledbetter EC. Applications of in vivo confocal microscopy in the management of infectious keratitis in veterinary ophthalmology. Vet Ophthalmol. 2021;25 Suppl 1:1-12. https://doi.org/10.1111/vop.12928
  7. Konstantopoulos A, Kuo J, Anderson D, Hossain P. Assessment of the use of anterior segment optical coherence tomography in microbial keratitis. Am J Ophthalmol. 2008;146(4):534-542. https://doi.org/10.1016/j.ajo.2008.05.030
  8. Takezawa Y, Suzuki T, Shiraishi A. Observation of retrocorneal plaques in patients with infectious keratitis using anterior segment optical coherence tomography. Cornea. 2017;36(10):1237-1242. https://doi.org/10.1097/ICO.0000000000001286
  9. Sharma N, Singhal D, Maharana PK, Agarwal T, Sinha R, Satpathy G, et al. Spectral domain anterior segment optical coherence tomography in fungal keratitis. Cornea. 2018;37(11):1388-1394. https://doi.org/10.1097/ICO.0000000000001715
  10. Pucket JD, Allbaugh RA, Rankin AJ. Treatment of dematiaceous fungal keratitis in a dog. J Am Vet Med Assoc. 2012;240(9):1104-1108. https://doi.org/10.2460/javma.240.9.1104
  11. Grey JE, Enoch S, Harding KG. Wound assessment. BMJ. 2006;332(7536):285-288. https://doi.org/10.1136/bmj.332.7536.285
  12. Grey JE, Harding KG, Enoch S. Venous and arterial leg ulcers. BMJ. 2006;332(7537):347-350. https://doi.org/10.1136/bmj.332.7537.347
  13. Cho CH, Lee SB. Clinical analysis of microbiologically proven fungal keratitis according to prior topical steroid use: a retrospective study in South Korea. BMC Ophthalmol. 2019;19(1):207.
  14. Sengupta J, Khetan A, Saha S, Banerjee D, Gangopadhyay N, Pal D. Candida keratitis: emerging problem in India. Cornea. 2012;31(4):371-375. https://doi.org/10.1097/ICO.0b013e31823f8a71
  15. Qiao GL, Ling J, Wong T, Yeung SN, Iovieno A. Candida keratitis: epidemiology, management, and clinical outcomes. Cornea. 2020;39(7):801-805. https://doi.org/10.1097/ICO.0000000000002306