대한수의학회지 (Korean Journal of Veterinary Research)

  • 제63권1호
  • /
  • Pages.5.1-5.9
  • /
  • 2023
  • /
  • 2466-1384(pISSN)
  • /
  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지
DOI QR코드

DOI QR Code

Immunogenicity of a new inactivated vaccine against feline panleukopenia virus, calicivirus, and herpesvirus-1 for cats

  • Dong-Kun Yang (Viral Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs) ;
  • Yu-Ri Park (Viral Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs) ;
  • Eun-Ju Kim (Viral Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs) ;
  • Hye Jeong Lee (Viral Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs) ;
  • Subin Oh (Viral Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs) ;
  • Bang-Hun Hyun (Viral Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs)
  • 투고 : 2022.12.30
  • 심사 : 2023.03.21
  • 발행 : 2023.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Feline panleukopenia virus (FPV), feline calicivirus (FCV), and feline herpesvirus type-1 (FHV-1) are major infectious pathogens in cats. We evaluated the immunogenicity of a new vaccine containing inactivated FPV, two FCVs, and FHV-1 in animals. An FPV, two FCVs, and an FHV-1 isolate were continuously passaged 70, 50, 80, and 100 times in CRFK cells. FP70, FC50, FC80, and FH100 were propagated and used as vaccine antigens. Two inactivated feline virus vaccines, feline rehydragel-adjuvanted vaccine (FRAV) and feline cabopol-adjuvanted vaccine (FCAV) were prepared and inoculated into mice and guinea pigs. Humoral immune responses were measured using hemagglutination inhibition (HI) for FPV and virus-neutralizing antibody (VNA) for two FCVs and FHV-1 tests. Serial passages in CRFK cells resulted in increase in titers of FPV and two FCVs but not FHV-1 The FCAV induced higher mean HI and VNA titers than the FRAV in guinea pigs; therefore, the FCAV was selected. Cats inoculated with FCAV developed a mean HI titer of 259.9 against FPV, and VNA titers of 64, 256, and 3.2 against FCV17D03, FCV17D283, and FHV191071, respectively. Therefore, cats inoculated with the FCAV showed a considerable immune response after receiving a booster vaccination.

키워드

과제정보

This study was supported financially by a grant (B-1543083-2019-21-01) from the Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea.

참고문헌

  1. Stuetzer B, Hartmann K. Feline parvovirus infection and associated diseases. Vet J 2014;201:150-155.  https://doi.org/10.1016/j.tvjl.2014.05.027
  2. Inthong N, Sutacha K, Kaewmongkol S, Sinsiri R, Sribuarod K, Sirinarumitr K, Sirinarumitr T. Feline panleukopenia virus as the cause of diarrhea in a banded linsang (Prionodon linsang) in Thailand. J Vet Med Sci 2019;81:1763-1768.  https://doi.org/10.1292/jvms.19-0238
  3. Parrish CR. Pathogenesis of feline panleukopenia virus and canine parvovirus. Baillieres Clin Haematol 1995;8:57-71.  https://doi.org/10.1016/S0950-3536(05)80232-X
  4. Radford AD, Coyne KP, Dawson S, Porter CJ, Gaskell RM. Feline calicivirus. Vet Res 2007;38:319-335.  https://doi.org/10.1051/vetres:2006056
  5. Coyne KP, Jones BR, Kipar A, Chantrey J, Porter CJ, Barber PJ, Dawson S, Gaskell RM, Radford AD. Lethal outbreak of disease associated with feline calicivirus infection in cats. Vet Rec 2006;158:544-550.  https://doi.org/10.1136/vr.158.16.544
  6. Lee Y, Maes R, Tai SS, Soboll Hussey G. Viral replication and innate immunity of feline herpesvirus-1 virulence-associated genes in feline respiratory epithelial cells. Virus Res 2019;264:56-67.  https://doi.org/10.1016/j.virusres.2019.02.013
  7. Maes R. Felid herpesvirus type 1 infection in cats: a natural host model for alphaherpesvirus pathogenesis. ISRN Vet Sci 2012;2012:495830. 
  8. Truyen U, Addie D, Belak S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Horzinek MC. Feline panleukopenia. ABCD guidelines on prevention and management. J Feline Med Surg 2009;11:538-546.  https://doi.org/10.1016/j.jfms.2009.05.002
  9. Radford AD, Addie D, Belak S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Thiry E, Truyen U, Horzinek MC. Feline calicivirus infection. ABCD guidelines on prevention and management. J Feline Med Surg 2009;11:556-564.  https://doi.org/10.1016/j.jfms.2009.05.004
  10. Thiry E, Addie D, Belak S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Truyen U, Horzinek MC. Feline herpesvirus infection. ABCD guidelines on prevention and management. J Feline Med Surg 2009;11:547-555.  https://doi.org/10.1016/j.jfms.2009.05.003
  11. Hueffer K, Parrish CR. Parvovirus host range, cell tropism and evolution. Curr Opin Microbiol 2003;6:392-398.  https://doi.org/10.1016/S1369-5274(03)00083-3
  12. Yang S, Wang S, Feng H, Zeng L, Xia Z, Zhang R, Zou X, Wang C, Liu Q, Xia X. Isolation and characterization of feline panleukopenia virus from a diarrheic monkey. Vet Microbiol 2010;143:155-159.  https://doi.org/10.1016/j.vetmic.2009.11.023
  13. Huang C, Hess J, Gill M, Hustead D. A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease. J Feline Med Surg 2010;12:129-137.  https://doi.org/10.1016/j.jfms.2009.08.006
  14. Lewin AC, Kolb AW, McLellan GJ, Bentley E, Bernard KA, Newbury SP, Brandt CR. Genomic, recombinational and phylogenetic characterization of global feline herpesvirus 1 isolates. Virology 2018;518:385-397.  https://doi.org/10.1016/j.virol.2018.03.018
  15. Yang DK, Park YR, Park Y, An S, Choi SS, Park J, Hyun BH. Isolation and molecular characterization of feline panleukopenia viruses from Korean cats. Korean J Vet Res 2022;62:e10. 
  16. Yang DK, Park YR, Yoo JY, Choi SS, Park Y, An S, Park J, Kim HJ, Kim J, Kim HH, Hyun BH. Biological and molecular characterization of feline caliciviruses isolated from cats in South Korea. Korean J Vet Res 2020;60:195-202.  https://doi.org/10.14405/kjvr.2020.60.4.195
  17. Yang DK, Kim HK, Park YR, Yoo JY, Choi SS, Park Y, An S, Park J, Kim J, Kim HJ, Lee J, Hyun BH. Isolation and molecular characterization of feline herpesvirus 1 from naturally infected Korean cats. J Bacteriol Virol 2020;50:263-272.  https://doi.org/10.4167/jbv.2020.50.4.263
  18. Jung JY, Lee K, Choi EJ, Lee H, Moon BY, Kim HY, So B. Cat diseases diagnosed in Korea, 2015~2017. Korean J Vet Serv 2018;41:119-123. 
  19. Yang DK, Park YR, Kim EJ, Lee HJ, Shin KS, Kim JH, Lee K, Hyun BH. Incidence and sero-surveillance of feline viruses in Korean cats residing in Gyeonggi-do. Korean J Vet Res 2022;62:e24. 
  20. Liu C, Liu Y, Qian P, Cao Y, Wang J, Sun C, Huang B, Cui N, Huo N, Wu H, Wang L, Xi X, Tian K. Molecular and serological investigation of cat viral infectious diseases in China from 2016 to 2019. Transbound Emerg Dis 2020;67:2329-2335.  https://doi.org/10.1111/tbed.13667
  21. Norval M, el-Ghorr A, Garssen J, Van Loveren H. The effects of ultraviolet light irradiation on viral infections. Br J Dermatol 1994;130:693-700.  https://doi.org/10.1111/j.1365-2133.1994.tb03404.x
  22. Mair KH, Koinig H, Gerner W, Hohne A, Bretthauer J, Kroll JJ, Roof MB, Saalmuller A, Stadler K, Libanova R. Carbopol improves the early cellular immune responses induced by the modified-life vaccine Ingelvac PRRS® MLV. Vet Microbiol 2015;176:352-357.  https://doi.org/10.1016/j.vetmic.2015.02.001
  23. Mumford JA, Wilson H, Hannant D, Jessett DM. Antigenicity and immunogenicity of equine influenza vaccines containing a Carbomer adjuvant. Epidemiol Infect 1994;112:421-437.  https://doi.org/10.1017/S0950268800057848
  24. Abd El-Moneam MM, Fathy NA, Ali NI, El Naggar HM. Improvements to the live-attenuated Newcastle disease virus vaccine using Carbopol® 940 as a stabilizer. Vet World 2020;13:1641-1646.  https://doi.org/10.14202/vetworld.2020.1641-1646
  25. Bergmann M, Schwertler S, Reese S, Speck S, Truyen U, Hartmann K. Antibody response to feline panleukopenia virus vaccination in healthy adult cats. J Feline Med Surg 2018;20:1087-1093.  https://doi.org/10.1177/1098612X17747740
  26. Lee SM, Yoon IJ, Choi HW, Lee KJ, Lee KY, Kim MK. Effect of a trivalent (FPV, FHV, FCV) inactivated vaccine in kittens. Korean J Vet Res 2005;45:311-323. 
  27. Bergmann M, Speck S, Rieger A, Truyen U, Hartmann K. Antibody response to feline herpesvirus-1 vaccination in healthy adult cats. J Feline Med Surg 2020;22:329-338. https://doi.org/10.1177/1098612X19845702