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Treatment for Burning Mouth Syndrome: A Clinical Review

  • YoungJoo Shim (Department of Oral Medicine, Daejeon Dental Hospital, Institute of Wonkwang Dental Research, College of Dentistry, Wonkwang University)
  • 투고 : 2023.01.05
  • 심사 : 2023.02.02
  • 발행 : 2023.03.30

초록

Burning mouth syndrome (BMS) is a chronic idiopathic orofacial pain. BMS is currently classified as a neuropathic pain condition, but it is difficult to pinpoint the precise neuropathic mechanisms involved in each patient. It is challenging to complete the cure for BMS. Clinicians should treat BMS patients based on evidence. There is pharmacological and non-pharmacological therapy in the treatment modalities of BMS. The provision of objective information and reassurance as part of cognitive behavioral therapy is critical in the treatment of BMS. This paper will review the evidence-based treatment of BMS and discuss what we need to do.

키워드

과제정보

This study was supported by Wonkwang University in 2022.

참고문헌

  1. International Classification of Orofacial Pain, 1st edition (ICOP). Cephalalgia 2020;40:129-221.  https://doi.org/10.1177/0333102419893823
  2. Jaaskelainen SK, Woda A. Burning mouth syndrome. Cephalalgia 2017;37:627-647.  https://doi.org/10.1177/0333102417694883
  3. Sardella A, Lodi G, Demarosi F, Bez C, Cassano S, Carrassi A. Burning mouth syndrome: a retrospective study investigating spontaneous remission and response to treatments. Oral Dis 2006;12:152-155.  https://doi.org/10.1111/j.1601-0825.2005.01174.x
  4. Jaaskelainen SK. Pathophysiology of primary burning mouth syndrome. Clin Neurophysiol 2012;123:71-77.  https://doi.org/10.1016/j.clinph.2011.07.054
  5. Forssell H, Jaaskelainen S, List T, Svensson P, Baad-Hansen L. An update on pathophysiological mechanisms related to idiopathic oro-facial pain conditions with implications for management. J Oral Rehabil 2015;42:300-322.  https://doi.org/10.1111/joor.12256
  6. Carreno-Hernandez I, Cassol-Spanemberg J, Rodriguez de Rivera-Campillo E, Estrugo-Devesa A, Lopez-Lopez J. Is burning mouth syndrome a neuropathic pain disorder? A systematic review. J Oral Facial Pain Headache 2021;35:218-229.  https://doi.org/10.11607/ofph.2861
  7. Woda A, Dao T, Gremeau-Richard C. Steroid dysregulation and stomatodynia (burning mouth syndrome). J Orofac Pain 2009;23:202-210. 
  8. Puhakka A, Forssell H, Soinila S, et al. Peripheral nervous system involvement in primary burning mouth syndrome--results of a pilot study. Oral Dis 2016;22:338-344.  https://doi.org/10.1111/odi.12454
  9. Yilmaz Z, Renton T, Yiangou Y, et al. Burning mouth syndrome as a trigeminal small fibre neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. J Clin Neurosci 2007;14:864-871.  https://doi.org/10.1016/j.jocn.2006.09.002
  10. Beneng K, Yilmaz Z, Yiangou Y, McParland H, Anand P, Renton T. Sensory purinergic receptor P2X3 is elevated in burning mouth syndrome. Int J Oral Maxillofac Surg 2010;39:815-819.  https://doi.org/10.1016/j.ijom.2010.03.013
  11. Hagelberg N, Forssell H, Rinne JO, et al. Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain 2003;101:149-154.  https://doi.org/10.1016/S0304-3959(02)00323-8
  12. Taiminen T, Kuusalo L, Lehtinen L, et al. Psychiatric (axis I) and personality (axis II) disorders in patients with burning mouth syndrome or atypical facial pain. Scand J Pain 2011;2:155-160.  https://doi.org/10.1016/j.sjpain.2011.06.004
  13. Orliaguet M, Misery L. Neuropathic and psychogenic components of burning mouth syndrome: a systematic review. Biomolecules 2021;11:1237. 
  14. Gremeau-Richard C, Dubray C, Aublet-Cuvelier B, Ughetto S, Woda A. Effect of lingual nerve block on burning mouth syndrome (stomatodynia): a randomized crossover trial. Pain 2010;149:27-32.  https://doi.org/10.1016/j.pain.2009.11.016
  15. Kim MJ, Kim J, Kho HS. Comparison of clinical characteristics between burning mouth syndrome patients with bilateral and unilateral symptoms. Int J Oral Maxillofac Surg 2020;49:38-43.  https://doi.org/10.1016/j.ijom.2019.06.013
  16. Tan HL, Smith JG, Hoffmann J, Renton T. A systematic review of treatment for patients with burning mouth syndrome. Cephalalgia 2022;42:128-161.  https://doi.org/10.1177/03331024211036152
  17. Sullivan MJL, Bishop SR, Pivik J. The pain catastrophizing scale: development and validation. Psychol Assess 1995;7:524-532.  https://doi.org/10.1037/1040-3590.7.4.524
  18. Brailo V, Firic M, Vucicevic Boras V, Andabak Rogulj A, Krstevski I, Alajbeg I. Impact of reassurance on pain perception in patients with primary burning mouth syndrome. Oral Dis 2016;22:512-516.  https://doi.org/10.1111/odi.12493
  19. Lee GS, Kim HK, Kim ME. Relevance of sleep, pain cognition, and psychological distress with regard to pain in patients with burning mouth syndrome. Cranio 2022;40:79-87.  https://doi.org/10.1080/08869634.2019.1681621
  20. Traeger AC, Hubscher M, Henschke N, Moseley GL, Lee H, McAuley JH. Effect of primary care-based education on reassurance in patients with acute low back pain: systematic review and metaanalysis. JAMA Intern Med 2015;175:733-743.  https://doi.org/10.1001/jamainternmed.2015.0217
  21. Bergdahl J, Anneroth G, Perris H. Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: a controlled study. J Oral Pathol Med 1995;24:213-215.  https://doi.org/10.1111/j.1600-0714.1995.tb01169.x
  22. Kim MJ, Kim J, Kho HS. Treatment outcomes and related clinical characteristics in patients with burning mouth syndrome. Oral Dis 2021;27:1507-1518.  https://doi.org/10.1111/odi.13693
  23. Cui Y, Xu H, Chen FM, et al. Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis. Oral Dis 2016;22:503-511.  https://doi.org/10.1111/odi.12422
  24. McMillan R, Forssell H, Buchanan JA, Glenny AM, Weldon JC, Zakrzewska JM. Interventions for treating burning mouth syndrome. Cochrane Database Syst Rev 2016;11:CD002779. 
  25. Tan SN, Song E, Dong XD, Somvanshi RK, Cairns BE. Peripheral GABAA receptor activation modulates rat tongue afferent mechanical sensitivity. Arch Oral Biol 2014;59:251-257.  https://doi.org/10.1016/j.archoralbio.2013.11.015
  26. Rodriguez de Rivera Campillo E, Lopez-Lopez J, ChimenosKustner E. Response to topical clonazepam in patients with burning mouth syndrome: a clinical study. Bull Group Int Rech Sci Stomatol Odontol 2010;49:19-29. 
  27. Ko JY, Kim MJ, Lee SG, Kho HS. Outcome predictors affecting the efficacy of clonazepam therapy for the management of burning mouth syndrome (BMS). Arch Gerontol Geriatr 2012;55:755-761.  https://doi.org/10.1016/j.archger.2011.10.001
  28. Marino R, Torretta S, Capaccio P, Pignataro L, Spadari F. Different therapeutic strategies for burning mouth syndrome: preliminary data. J Oral Pathol Med 2010;39:611-616.  https://doi.org/10.1111/j.1600-0714.2010.00922.x
  29. Lopez-D'alessandro E, Escovich L. Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial. Med Oral Patol Oral Cir Bucal 2011;16:e635-e640.  https://doi.org/10.4317/medoral.16942
  30. Kim MJ, Kho HS. Treatment outcomes of venlafaxine and duloxetine in refractory burning mouth syndrome patients. J Oral Med Pain 2019;44:83-91.  https://doi.org/10.14476/jomp.2019.44.3.83
  31. de Pedro M, Lopez-Pintor RM, Casanas E, Hernandez G. Effects of photobiomodulation with low-level laser therapy in burning mouth syndrome: a randomized clinical trial. Oral Dis 2020;26:1764-1776.  https://doi.org/10.1111/odi.13443
  32. Umezaki Y, Badran BW, DeVries WH, Moss J, Gonzales T, George MS. The efficacy of daily prefrontal repetitive transcranial magnetic stimulation (rTMS) for burning mouth syndrome (BMS): a randomized controlled single-blind study. Brain Stimul 2016;9:234-242.  https://doi.org/10.1016/j.brs.2015.10.005
  33. Lopez-Jornet P, Camacho-Alonso F, Andujar-Mateos P. A prospective, randomized study on the efficacy of tongue protector in patients with burning mouth syndrome. Oral Dis 2011;17:277-282.  https://doi.org/10.1111/j.1601-0825.2010.01737.x
  34. Galli F, Lodi G, Sardella A, Vegni E. Role of psychological factors in burning mouth syndrome: a systematic review and metaanalysis. Cephalalgia 2017;37:265-277. https://doi.org/10.1177/0333102416646769